PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32903039-5 2021 IL-17A had also a synergistic destruction to MIN6 cells with streptozotocin (STZ), a pancreatic beta-cell-specific cytotoxin. Streptozocin 77-80 interleukin 17A Mus musculus 0-6 34038731-4 2021 These changes lead to a consequent increase in interleukin 17 (IL-17) production within the pancreas and higher incidence of diabetes in streptozotocin (STZ)-injected mice. Streptozocin 137-151 interleukin 17A Mus musculus 63-68 34038731-4 2021 These changes lead to a consequent increase in interleukin 17 (IL-17) production within the pancreas and higher incidence of diabetes in streptozotocin (STZ)-injected mice. Streptozocin 153-156 interleukin 17A Mus musculus 47-61 34038731-4 2021 These changes lead to a consequent increase in interleukin 17 (IL-17) production within the pancreas and higher incidence of diabetes in streptozotocin (STZ)-injected mice. Streptozocin 153-156 interleukin 17A Mus musculus 63-68 33911193-4 2022 Diabetes was induced in both wild-type and IL-17 knockout mice by intraperitoneal injection of streptozotocin (STZ). Streptozocin 95-109 interleukin 17A Mus musculus 43-48 33911193-4 2022 Diabetes was induced in both wild-type and IL-17 knockout mice by intraperitoneal injection of streptozotocin (STZ). Streptozocin 111-114 interleukin 17A Mus musculus 43-48 33691614-0 2021 IL-17 deficiency aggravates the streptozotocin-induced diabetic nephropathy through the reduction of autophagosome formation in mice. Streptozocin 32-46 interleukin 17A Mus musculus 0-5 33691614-5 2021 METHODS: The autophagic response of IL-17A to STZ-induced nephrotoxicity was evaluated by analyzing STZ-induced functional and histological renal injury in IL-17A knockout (KO) mice. Streptozocin 46-49 interleukin 17A Mus musculus 36-42 33691614-5 2021 METHODS: The autophagic response of IL-17A to STZ-induced nephrotoxicity was evaluated by analyzing STZ-induced functional and histological renal injury in IL-17A knockout (KO) mice. Streptozocin 100-103 interleukin 17A Mus musculus 36-42 33691614-6 2021 RESULTS: IL-17A KO STZ-treated mice developed more severe nephropathy than STZ-treated wild-type (WT) mice, with increased glomerular damage and renal interstitial fibrosis at 12 weeks. Streptozocin 19-22 interleukin 17A Mus musculus 9-15 33691614-7 2021 IL-17A deficiency also increased the up-regulation of proinflammatory cytokines and fibrotic gene expression after STZ treatment. Streptozocin 115-118 interleukin 17A Mus musculus 0-6 33691614-9 2021 However, IL-17A KO STZ-treated mice displayed a significant decrease in protein expression. Streptozocin 19-22 interleukin 17A Mus musculus 9-15 33691614-10 2021 Especially, the levels of LC3 and ATG7, which play crucial roles in autophagosome formation, were notably decreased in the IL-17A KO STZ-treated mice compared with their WT counterparts. Streptozocin 133-136 interleukin 17A Mus musculus 123-129 33691614-11 2021 CONCLUSIONS: IL-17 deficiency aggravates of STZ-induced DN via attenuation of autophagic response. Streptozocin 44-47 interleukin 17A Mus musculus 13-18 33691614-12 2021 Our study demonstrated that IL-17A mediates STZ-induced renal damage and represents a potential therapeutic target in DN. Streptozocin 44-47 interleukin 17A Mus musculus 28-34 32903039-5 2021 IL-17A had also a synergistic destruction to MIN6 cells with streptozotocin (STZ), a pancreatic beta-cell-specific cytotoxin. Streptozocin 61-75 interleukin 17A Mus musculus 0-6 27790217-7 2016 Intracellular cytokine analysis in splenic T cells demonstrated that inhibition of AChE led to a shift in STZ-induced immune response from a predominantly disease-causing IL-17-expressing Th17 cells to IFNgamma-positive Th1 cells. Streptozocin 106-109 interleukin 17A Mus musculus 171-176 27878497-1 2016 Using the model of hypogonadism in C57Bl/6 male mice, we showed that injection of streptozotocin to newborn animals and high-fat diet induced serum IFN-gamma and IL-17 elevation, glucose metabolism disturbances, insulin resistance, destructive changes of the Langerhans islets (deficit of PDX1+beta cells), while the number of oligopotent beta cell precursors (CD45-TER119-CD133+CD49flow) increased. Streptozocin 82-96 interleukin 17A Mus musculus 162-167 30783187-7 2019 We conclude that absence of IL-17 signalling is protective against streptozotocin-induced diabetic nephropathy, thus implying a pro-inflammatory role of IL-17 in its pathogenesis. Streptozocin 67-81 interleukin 17A Mus musculus 28-33 30783187-7 2019 We conclude that absence of IL-17 signalling is protective against streptozotocin-induced diabetic nephropathy, thus implying a pro-inflammatory role of IL-17 in its pathogenesis. Streptozocin 67-81 interleukin 17A Mus musculus 153-158 29305939-4 2018 Knockout of IL-17 improved cardiac function of diabetic mice induced by streptozotocin (STZ), and significantly alleviated interstitial fibrosis as manifested by reduced collagen mRNA expression and collagen deposition evaluated by Masson"s staining. Streptozocin 72-86 interleukin 17A Mus musculus 12-17 29305939-4 2018 Knockout of IL-17 improved cardiac function of diabetic mice induced by streptozotocin (STZ), and significantly alleviated interstitial fibrosis as manifested by reduced collagen mRNA expression and collagen deposition evaluated by Masson"s staining. Streptozocin 88-91 interleukin 17A Mus musculus 12-17 26211676-0 2015 Interleukin-17A deficiency ameliorates streptozotocin-induced diabetes. Streptozocin 39-53 interleukin 17A Mus musculus 0-15 26211676-12 2015 In summary, our study has revealed a pathogenic role of IL-17 in an STZ-induced diabetes model with important implications for our understanding of IL-17 function in autoimmune diseases. Streptozocin 68-71 interleukin 17A Mus musculus 148-153 26211676-3 2015 In the current study, we investigated the impact of IL-17 deficiency on streptozotocin (STZ) -induced diabetes. Streptozocin 72-86 interleukin 17A Mus musculus 52-57 26211676-3 2015 In the current study, we investigated the impact of IL-17 deficiency on streptozotocin (STZ) -induced diabetes. Streptozocin 88-91 interleukin 17A Mus musculus 52-57 26211676-4 2015 Il-17(-/-) mice exhibited attenuated hyperglycaemia and insulitis after STZ treatment compared with control mice. Streptozocin 72-75 interleukin 17A Mus musculus 0-5 26211676-5 2015 The Il-17(-/-) mice had fewer CD8(+) cells infiltrating the pancreas than wild-type controls after STZ injection. Streptozocin 99-102 interleukin 17A Mus musculus 4-9 26211676-11 2015 These data suggest that IL-17 is required in splenic MDSC function after STZ delivery. Streptozocin 73-76 interleukin 17A Mus musculus 24-29 26211676-12 2015 In summary, our study has revealed a pathogenic role of IL-17 in an STZ-induced diabetes model with important implications for our understanding of IL-17 function in autoimmune diseases. Streptozocin 68-71 interleukin 17A Mus musculus 56-61 16261264-5 2005 Finally, a significant increase in blood IL-17 levels was observed in a multiple low-dose streptozotocin model of diabetes, suggesting that T cell-derived IL-17 might be involved in NO-dependent damage of beta cells in this disease. Streptozocin 90-104 interleukin 17A Mus musculus 41-46 16261264-5 2005 Finally, a significant increase in blood IL-17 levels was observed in a multiple low-dose streptozotocin model of diabetes, suggesting that T cell-derived IL-17 might be involved in NO-dependent damage of beta cells in this disease. Streptozocin 90-104 interleukin 17A Mus musculus 155-160