PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34279193-10	2021	In STZ induced diabetes mice models, microglia NLRP3, ASC, and caspase-1 proteins were highly expressed, and serum cytokines IL-1beta, IL6, IL18, and TNFalpha were remarkably increased.	Streptozocin	3-6	interleukin 18	Mus musculus	140-144	
34685620-8	2021	STZ-induced diabetic cardiomyopathy significantly increased inflammasome formation (TLR4, NLRP3, Nek7, and GBP5), pyroptosis markers (caspase-1, IL-1beta, and IL-18), inflammatory cytokines (IL-6 and TNF-alpha), MMP9, and infiltration of monocytes (CD14), macrophage (iNOS), and dendritic cells (CD11b and CD11c) (p < 0.05).	Streptozocin	0-3	interleukin 18	Mus musculus	159-164	
32295112-0	2020	The DNA Sensor AIM2 Protects against Streptozotocin-Induced Type 1 Diabetes by Regulating Intestinal Homeostasis via the IL-18 Pathway.	Streptozocin	37-51	interleukin 18	Mus musculus	121-126	
32295112-7	2020	Mechanistically, the AIM2 inflammasome is activated in vivo, leading to an IL-18 release in the ileum at 15 days after an STZ injection.	Streptozocin	122-125	interleukin 18	Mus musculus	75-80	
32295112-9	2020	Together, our findings show a regulatory role of AIM2, mediated by IL-18, in shaping gut microbiota and reducing bacterial translocation and proinflammatory response against insulin-producing beta cells, which ultimately results in protection against T1D onset in an STZ-induced diabetes model.	Streptozocin	267-270	interleukin 18	Mus musculus	67-72	
29435463-4	2017	Results: SAA and IL-18 levels were significantly elevated in diabetic mice (STZ) compared to control (WT) mice, and there was a significant attenuation of inflammation in diabetic NLRP3-KO mice (NLRP3-KO STZ) compared to control mice (p &lt; 0.005).	Streptozocin	76-79	interleukin 18	Mus musculus	17-22	
12884303-0	2003	Essential pathogenic role of endogenous IL-18 in murine diabetes induced by multiple low doses of streptozotocin.	Streptozocin	98-112	interleukin 18	Mus musculus	40-45	
12884303-8	2003	We conclude that intact IL-18 function is essential for the full diabetogenic effect of low dose STZ in C57BL/6 mice.	Streptozocin	97-100	interleukin 18	Mus musculus	24-29	
26923011-8	2016	The STZ treatment also increased the number of Iba-1-positive and CD68-positive microglial cells, astrocytes, and IL-1beta, IL-6, IL-10, and IL-18 levels in the hippocampus, but not in the midbrain or cerebellum.	Streptozocin	4-7	interleukin 18	Mus musculus	141-146	
22733969-8	2012	Adoptive transfer of unstimulated and IL-18-stimulated NK cells into streptozotocin-treated mice led to a delayed diabetes development and partial disease prevention in the group treated with IL-18-stimulated NK cells.	Streptozocin	69-83	interleukin 18	Mus musculus	38-43	
22733969-8	2012	Adoptive transfer of unstimulated and IL-18-stimulated NK cells into streptozotocin-treated mice led to a delayed diabetes development and partial disease prevention in the group treated with IL-18-stimulated NK cells.	Streptozocin	69-83	interleukin 18	Mus musculus	192-197