PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24165164-4 2014 Herein, we demonstrated that certain antitumor 1,4-NQs, including spermidine-1,4-NQ, lapachol, and nor-lapachol display inhibitory activity on human MAO-A and MAO-B. 1,4-naphthoquinone 47-54 monoamine oxidase B Homo sapiens 159-164 22071524-5 2011 Herein we show that MAO-B was inhibited competitively by 1,4-NQ (K(i)=1.4 muM) whereas MAO-A was inhibited by non-competitive mechanism (K(i)=7.7 muM). 1,4-naphthoquinone 57-63 monoamine oxidase B Homo sapiens 20-25 22071524-8 2011 Additionally, docking studies suggest the phenyl side groups of Tyr407 and Tyr444 (for MAO-A) or Tyr398 and Tyr435 (for MAO-B) play an important role in the interaction of the enzyme with 1,4-NQ scaffold through forces of dispersion as verified for menadione, TMN and 1,4-NQ. 1,4-naphthoquinone 188-194 monoamine oxidase B Homo sapiens 120-125 22071524-8 2011 Additionally, docking studies suggest the phenyl side groups of Tyr407 and Tyr444 (for MAO-A) or Tyr398 and Tyr435 (for MAO-B) play an important role in the interaction of the enzyme with 1,4-NQ scaffold through forces of dispersion as verified for menadione, TMN and 1,4-NQ. 1,4-naphthoquinone 268-274 monoamine oxidase B Homo sapiens 120-125