PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28034739-5 2018 Moreover, although results from gene deletion experiments in the literature provide strong support for the primacy of the T1R2 + T1R3 heterodimer in the taste transduction of sugars and other sweeteners, there is also growing evidence suggesting that there may be T1R-independent receptor mechanism(s) activated by select sugars, especially glucose. Sugars 175-181 taste receptor, type 1, member 3 Mus musculus 129-133 29625018-4 2018 Sweet taste receptor ( tas1r2/tas1r3/gnat3/gnat1) sugar transporter ( slc5a1, slc2a2, slc2a5) and putative sugar sensor ( slc5a4a and slc5a4b) gene expression levels were highest in tongue and proximal and distal small intestine, respectively. Sugars 50-55 taste receptor, type 1, member 3 Mus musculus 30-36 21383163-1 2011 Although the heteromeric combination of type 1 taste receptors 2 and 3 (T1r2 + T1r3) is well established as the major receptor for sugars and noncaloric sweeteners, there is also evidence of T1r-independent sweet taste in mice, particularly so for sugars. Sugars 131-137 taste receptor, type 1, member 3 Mus musculus 79-83 27162343-2 2016 However, in the absence of T1R2+T1R3 (e.g., in Tas1r3 KO mice), animals still respond to sugars, arguing for the presence of T1R-independent detection mechanism(s). Sugars 89-95 taste receptor, type 1, member 3 Mus musculus 47-53 27526998-2 2016 Sugar taste is mediated by the T1R2/T1R3 sweet taste receptor, while maltodextrin taste is dependent upon a different as yet unidentified receptor. Sugars 0-5 taste receptor, type 1, member 3 Mus musculus 36-40 26107521-8 2015 Collectively, the obtained data demonstrate that the T1R3 receptor protein plays an important role in control of glucose homeostasis not only by regulating sugar intake but also via its extraoral function, probably in the pancreas and brain. Sugars 156-161 taste receptor, type 1, member 3 Mus musculus 53-57 26028411-7 2015 It has been proposed that the T1R2/T1R3 receptor complex acts as sweet sensor in the intestine, and plays a pivotal role in sensing sugars and maintaining glucose homeostasis through incretin secretion. Sugars 132-138 taste receptor, type 1, member 3 Mus musculus 35-39 22683548-2 2012 T1r3, encoded by Tas1r3, is part of the T1r2+T1r3 sugar taste receptor, while Trpm5 mediates signaling for G protein-coupled receptors in taste cells. Sugars 50-55 taste receptor, type 1, member 3 Mus musculus 0-4 22683548-2 2012 T1r3, encoded by Tas1r3, is part of the T1r2+T1r3 sugar taste receptor, while Trpm5 mediates signaling for G protein-coupled receptors in taste cells. Sugars 50-55 taste receptor, type 1, member 3 Mus musculus 17-23 22683548-2 2012 T1r3, encoded by Tas1r3, is part of the T1r2+T1r3 sugar taste receptor, while Trpm5 mediates signaling for G protein-coupled receptors in taste cells. Sugars 50-55 taste receptor, type 1, member 3 Mus musculus 45-49 21376068-3 2011 T1R2 combines with T1R3 to form a heterodimer that binds with sugars and other sweeteners. Sugars 62-68 taste receptor, type 1, member 3 Mus musculus 19-23 21383163-1 2011 Although the heteromeric combination of type 1 taste receptors 2 and 3 (T1r2 + T1r3) is well established as the major receptor for sugars and noncaloric sweeteners, there is also evidence of T1r-independent sweet taste in mice, particularly so for sugars. Sugars 248-254 taste receptor, type 1, member 3 Mus musculus 79-83 20926763-5 2010 In experiment 1, we predicted that if activation of gut T1R3 mediates sugar reinforcement, then IG infusions of a nutritive (sucrose) or nonnutritive (sucralose) ligand for this receptor should condition a preference for the CS+ in B6 wild-type (WT) mice. Sugars 70-75 taste receptor, type 1, member 3 Mus musculus 56-60 20063013-6 2010 We demonstrate the expression of the T1R subtype T1R3, which is essential for the detection of both sugars and amino acids in the gustatory system, in two distinct cell populations of the gastric mucosa. Sugars 100-106 taste receptor, type 1, member 3 Mus musculus 49-53 20600198-1 2010 We examined sugar-induced obesity in mouse strains polymorphic for Tas1r3, a gene that codes for the T1R3 sugar taste receptor. Sugars 12-17 taste receptor, type 1, member 3 Mus musculus 67-73 20600198-1 2010 We examined sugar-induced obesity in mouse strains polymorphic for Tas1r3, a gene that codes for the T1R3 sugar taste receptor. Sugars 12-17 taste receptor, type 1, member 3 Mus musculus 101-105 20600198-1 2010 We examined sugar-induced obesity in mouse strains polymorphic for Tas1r3, a gene that codes for the T1R3 sugar taste receptor. Sugars 106-111 taste receptor, type 1, member 3 Mus musculus 67-73 20600198-1 2010 We examined sugar-induced obesity in mouse strains polymorphic for Tas1r3, a gene that codes for the T1R3 sugar taste receptor. Sugars 106-111 taste receptor, type 1, member 3 Mus musculus 101-105 20600198-2 2010 The T1R3 receptor in the FVB and B6 strains has a higher affinity for sugars than that in the AKR and 129P3 strains. Sugars 70-76 taste receptor, type 1, member 3 Mus musculus 4-8 19091911-10 2009 The experience-induced sucrose preference is attributed to a post-oral conditioned preference for the T1R3-independent orosensory features of the sugar solutions (odor, texture, T1R2-mediated taste). Sugars 146-151 taste receptor, type 1, member 3 Mus musculus 102-106 19736224-1 2009 Prior work has shown that sweet taste-deficient T1R3 knockout (KO) mice developed significant sucrose preferences when given long-term sugar versus water tests. Sugars 135-140 taste receptor, type 1, member 3 Mus musculus 48-52 19736224-8 2009 These results indicate that olfaction plays a critical role in the conditioned preference of T1R3 KO mice for dilute sugar solutions. Sugars 117-122 taste receptor, type 1, member 3 Mus musculus 93-97 19211717-10 2009 These results provide evidence for 1) the existence of multiple transduction pathways underlying responses to sugars: a T1R3-independent GS pathway for sucrose and glucose, and a TRPM5-independent temperature sensitive GS pathway for glucose; 2) the requirement for Galphagust in GS sweet taste responses; and 3) the existence of a sweet independent pathway for saccharin, in mouse taste cells on the anterior tongue. Sugars 110-116 taste receptor, type 1, member 3 Mus musculus 120-124 17911381-4 2007 Allelic variation of the Tas1r3 gene influenced taste responsiveness to nonnutritive sweeteners (saccharin, acesulfame-K, sucralose, SC-45647), sugars (sucrose, maltose, glucose, fructose), sugar alcohols (erythritol, sorbitol), and some amino acids (D-tryptophan, D-phenylalanine, L-proline). Sugars 144-150 taste receptor, type 1, member 3 Mus musculus 25-31 12869700-3 2003 Here,we show that mice lacking T1r3 showed no preference for artificial sweeteners and had diminished but not abolished behavioral and nerve responses to sugars and umami compounds. Sugars 154-160 taste receptor, type 1, member 3 Mus musculus 31-35 17942718-1 2007 In taste bud cells, two different T1R heteromeric taste receptors mediate signal transduction of sugars (the canonical "sweet" taste receptor, T1R2 + T1R3) and L-amino acids (the T1R1 + T1R3 receptor). Sugars 97-103 taste receptor, type 1, member 3 Mus musculus 150-154 17724332-0 2007 T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. Sugars 32-38 taste receptor, type 1, member 3 Mus musculus 0-4 17724332-4 2007 Here, we show that the sweet taste receptor subunit T1R3 and the taste G protein gustducin, expressed in enteroendocrine cells, underlie intestinal sugar sensing and regulation of SGLT1 mRNA and protein. Sugars 148-153 taste receptor, type 1, member 3 Mus musculus 52-56 21940444-4 2011 Importantly, the experience-dependent increase in responsiveness to the sugars observed with the T1R2 and T1R3 single KO mice was not statistically significant in the T1R2/3 double KO mice. Sugars 72-78 taste receptor, type 1, member 3 Mus musculus 106-110