PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8137868-2 1994 The effects of two months of streptozotocin-induced diabetes and aldose reductase inhibition on body weight, plasma glucose, and nerve sugars and polyols were comparable to those reported previously. Sugars 135-141 aldo-keto reductase family 1 member B1 Rattus norvegicus 65-81 8076666-6 1994 These data suggest that exaggerated sugar metabolism by aldose reductase may restrict the ability of nerve to initiate regeneration but is not responsible for the reduced distance of nerve regeneration or attenuated increase in vasoactive intestinal polypeptide production that occur after crush injury of diabetic rats. Sugars 36-41 aldo-keto reductase family 1 member B1 Rattus norvegicus 56-72 1308788-2 1992 Aldose reductase catalyzes the NADPH-linked reduction of hexoses to their respective sugar-alcohols, which are involved in the pathogenesis of "sugar-cataracts". Sugars 85-90 aldo-keto reductase family 1 member B1 Rattus norvegicus 0-16 1476067-1 1992 The localization of aldose reductase (AR), which is thought to be involved in the pathogenesis of sugar and galactosemic cataracts, has been studied using various methods. Sugars 98-103 aldo-keto reductase family 1 member B1 Rattus norvegicus 20-36 1476067-1 1992 The localization of aldose reductase (AR), which is thought to be involved in the pathogenesis of sugar and galactosemic cataracts, has been studied using various methods. Sugars 98-103 aldo-keto reductase family 1 member B1 Rattus norvegicus 38-40 2120146-1 1990 Aldose reductase (AR) is implicated in the development of sugar cataracts by its reduction of galactose or glucose to polyols. Sugars 58-63 aldo-keto reductase family 1 member B1 Rattus norvegicus 0-16 2176946-8 1990 These results demonstrate that increased availability of galactose, a high-affinity substrate for the enzyme, leads to increased aldose reductase messenger RNA, which suggests a role for aldose reductase in sugar metabolism in the lens. Sugars 207-212 aldo-keto reductase family 1 member B1 Rattus norvegicus 129-145 2176946-8 1990 These results demonstrate that increased availability of galactose, a high-affinity substrate for the enzyme, leads to increased aldose reductase messenger RNA, which suggests a role for aldose reductase in sugar metabolism in the lens. Sugars 207-212 aldo-keto reductase family 1 member B1 Rattus norvegicus 187-203 2120146-1 1990 Aldose reductase (AR) is implicated in the development of sugar cataracts by its reduction of galactose or glucose to polyols. Sugars 58-63 aldo-keto reductase family 1 member B1 Rattus norvegicus 18-20 6799419-4 1982 This strongly suggests that aldose reductase is the common factor involved in the formation of sugar cataracts. Sugars 95-100 aldo-keto reductase family 1 member B1 Rattus norvegicus 28-44 3927328-1 1985 Aldose reductase is implicated in the pathogenesis of sugar cataracts; therefore, inhibition of this enzyme subsequent to cataractogenesis may represent a therapeutic approach for the restoration of lens physiology despite the persistence of diabetes or galactosemia. Sugars 54-59 aldo-keto reductase family 1 member B1 Rattus norvegicus 0-16 6817723-1 1982 The concomitant protective effects of the aldose reductase inhibitor, 7-dimethylsulfamoyl-xanthone-2-carboxylic acid, were established by three lens parameters (soluble crystallin proteins, growth and cell hydration) because their quantitation provided a comprehensive index of lens physiology during sugar cataractogenesis in the rat neonate. Sugars 301-306 aldo-keto reductase family 1 member B1 Rattus norvegicus 42-58 33146867-1 2021 Cellular redox dysregulation produced by aldose reductase (AR) in the presence of high blood sugar is a mechanism involved in neurodegeneration commonly observed in diabetes mellitus (DM) and Parkinson"s disease (PD); therefore, AR is a key target for treatment of both diseases. Sugars 93-98 aldo-keto reductase family 1 member B1 Rattus norvegicus 41-57 45423-2 1979 Sugars in excess are converted to polyols by lens AR. Sugars 0-6 aldo-keto reductase family 1 member B1 Rattus norvegicus 50-52 45423-7 1979 Moreover, AR inhibitors were shown to effectively delay the onset of sugar cataract development in animals. Sugars 69-74 aldo-keto reductase family 1 member B1 Rattus norvegicus 10-12 21376710-10 2011 However, we examined the effect of AKR1B1 knockdown on sugar-induced lens opacification in ex vivo. Sugars 55-60 aldo-keto reductase family 1 member B1 Rattus norvegicus 35-41 21376710-12 2011 Biochemical analysis of lens homogenates showed that the AKR1B1 activity and sorbitol levels were significantly lower in sugar-treated AKR1B1 knockdown rat lenses as compared to WT rat lenses treated with 50mM glucose. Sugars 121-126 aldo-keto reductase family 1 member B1 Rattus norvegicus 57-63 21376710-12 2011 Biochemical analysis of lens homogenates showed that the AKR1B1 activity and sorbitol levels were significantly lower in sugar-treated AKR1B1 knockdown rat lenses as compared to WT rat lenses treated with 50mM glucose. Sugars 121-126 aldo-keto reductase family 1 member B1 Rattus norvegicus 135-141 21376710-13 2011 Our results thus confirmed the significance of AKR1B1 in the mediation of sugar-induced lens opacification and indicate the use of AKR1B1 inhibitors in the prevention of cataractogenesis. Sugars 74-79 aldo-keto reductase family 1 member B1 Rattus norvegicus 47-53 15707781-4 2005 Therefore, agents that can inhibit AR and prevent sorbitol accumulation may be helpful to combat sugar-induced cataract. Sugars 97-102 aldo-keto reductase family 1 member B1 Rattus norvegicus 35-37 20823582-1 2010 High sugar levels found in diabetic cataract cause the opacification of lenses by osmotic changes induced via the aldose reductase (AR)-mediated polyol pathway. Sugars 5-10 aldo-keto reductase family 1 member B1 Rattus norvegicus 114-130 20823582-1 2010 High sugar levels found in diabetic cataract cause the opacification of lenses by osmotic changes induced via the aldose reductase (AR)-mediated polyol pathway. Sugars 5-10 aldo-keto reductase family 1 member B1 Rattus norvegicus 132-134 19555177-2 2009 Aldose reductase has been reported to play an important role in sugar-induced cataract. Sugars 64-69 aldo-keto reductase family 1 member B1 Rattus norvegicus 0-16 17444799-0 2007 Topical aldose reductase inhibitor formulations for effective lens drug delivery in a rat model for sugar cataracts. Sugars 100-105 aldo-keto reductase family 1 member B1 Rattus norvegicus 8-24 15707781-3 2005 The high sugar levels in diabetes may cause tissue disruption and intumescences by osmotic changes induced via aldose reductase (AR) mediated polyol pathway. Sugars 9-14 aldo-keto reductase family 1 member B1 Rattus norvegicus 111-127 15707781-3 2005 The high sugar levels in diabetes may cause tissue disruption and intumescences by osmotic changes induced via aldose reductase (AR) mediated polyol pathway. Sugars 9-14 aldo-keto reductase family 1 member B1 Rattus norvegicus 129-131 11520112-11 2001 Despite differences in the etiology of diabetes mellitus, the strain of rat and the rate of disease progression in the OLETF rat model compared with other diabetic models, the present results support the theory that the polyol pathway via AR is a factor in the development of sugar cataracts. Sugars 276-281 aldo-keto reductase family 1 member B1 Rattus norvegicus 239-241 15321028-1 2004 The initiation of sugar cataract formation by the aldose reductase catalyzed accumulation of sorbitol in diabetic rats, and its prevention by the administration of aldose reductase inhibitors at the onset or early stages of diabetes, has been well established. Sugars 18-23 aldo-keto reductase family 1 member B1 Rattus norvegicus 50-66 9733586-8 1998 These results support the concept that sugar cataract formation is initiated by the aldose reductase catalysed intracellular accumulation of polyols and that these sugar cataracts can be prevented through inhibition of aldose reductase. Sugars 39-44 aldo-keto reductase family 1 member B1 Rattus norvegicus 84-100 10803425-11 2000 These results support the concept that sugar cataract formation is initiated by the aldose reductase catalyzed intracellular accumulation of polyols and that these sugar cataracts can be prevented through inhibition of aldose reductase. Sugars 39-44 aldo-keto reductase family 1 member B1 Rattus norvegicus 84-100 10803425-11 2000 These results support the concept that sugar cataract formation is initiated by the aldose reductase catalyzed intracellular accumulation of polyols and that these sugar cataracts can be prevented through inhibition of aldose reductase. Sugars 39-44 aldo-keto reductase family 1 member B1 Rattus norvegicus 219-235 10803425-11 2000 These results support the concept that sugar cataract formation is initiated by the aldose reductase catalyzed intracellular accumulation of polyols and that these sugar cataracts can be prevented through inhibition of aldose reductase. Sugars 164-169 aldo-keto reductase family 1 member B1 Rattus norvegicus 219-235 11003161-4 2000 Subsequent in vitro culture studies of rat lenses with 11 indicated that this series of aldose reductase inhibitors are effective in either preventing or retarding sugar cataract formation associated with diabetes. Sugars 164-169 aldo-keto reductase family 1 member B1 Rattus norvegicus 88-104 9733586-8 1998 These results support the concept that sugar cataract formation is initiated by the aldose reductase catalysed intracellular accumulation of polyols and that these sugar cataracts can be prevented through inhibition of aldose reductase. Sugars 39-44 aldo-keto reductase family 1 member B1 Rattus norvegicus 219-235 9733586-8 1998 These results support the concept that sugar cataract formation is initiated by the aldose reductase catalysed intracellular accumulation of polyols and that these sugar cataracts can be prevented through inhibition of aldose reductase. Sugars 164-169 aldo-keto reductase family 1 member B1 Rattus norvegicus 219-235 10684012-1 1998 This study was designed to evaluate the changes and the role of lens epithelium in sugar cataract formation, in regard to the fact that the highest level of aldose reductase is found in this layer of lens. Sugars 83-88 aldo-keto reductase family 1 member B1 Rattus norvegicus 157-173