PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17278394-5 2006 It binds to neutral sugar arrays on microorganisms and acts as an opsonin either directly (by binding to cell-surface calreticulin) or indirectly by activating complement. Sugars 20-25 calreticulin Homo sapiens 118-130 33107166-2 2020 After the removal of specific sugar residues, glycoproteins acquire signals in the glycoprotein quality control (GPQC) system and enter the folding cycle composed of lectin-chaperones calnexin (CNX) and calreticulin (CRT), glucosidase II (G-II), and UDP-Glc:glycoprotein glucosyltransferase (UGGT). Sugars 30-35 calreticulin Homo sapiens 203-215 22086461-12 2012 The details therefore, strongly implicate gentamicin as a competitive inhibitor of sugar binding with calreticulin. Sugars 83-88 calreticulin Homo sapiens 102-114 14705935-3 2004 To provide further insight into these lectin-glycan interactions, we are investigating the interaction of CRT with various sugars. Sugars 123-129 calreticulin Homo sapiens 106-109 14705935-4 2004 We have earlier modeled the complex between CRT and the Glc(1)Man(3) tetrasaccharide, a derivative of the native Glc(1)Man(9)GlcNAc(2) sugar moiety. Sugars 135-140 calreticulin Homo sapiens 44-47 14705935-5 2004 Here, we have systematically mutated the residues implicated by the model in the interaction of CRT to its sugar substrates and categorized the role played by each of the subsites of calreticulin toward the glycan binding. Sugars 107-112 calreticulin Homo sapiens 96-99 14705935-10 2004 These studies provide detailed molecular insight into the sugar binding specificity of CRT. Sugars 58-63 calreticulin Homo sapiens 87-90