PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8033806-12	1994	Convulsions induced by pentylenetetrazole administration resulted in an increased expression of the NGFI-A gene, which is of similar magnitude in control and hypothyroid rats.	Pentylenetetrazole	23-41	early growth response 1	Rattus norvegicus	100-106	
23744421-0	2013	Changes in the Egr1 and Arc expression in brain structures of pentylenetetrazole-kindled rats.	Pentylenetetrazole	62-80	early growth response 1	Rattus norvegicus	15-19	
23744421-4	2013	METHODS: In this study, we sought to explore how the spread of epileptiform activity (pentylenetetrazole (PTZ)-induced kindling) in the brain activates egr1, the early growth response gene, a member of the immediate early gene (IEG) family, and arc (activity-regulated cytoskeleton-associated protein) expression.	Pentylenetetrazole	86-104	early growth response 1	Rattus norvegicus	152-156	
23744421-4	2013	METHODS: In this study, we sought to explore how the spread of epileptiform activity (pentylenetetrazole (PTZ)-induced kindling) in the brain activates egr1, the early growth response gene, a member of the immediate early gene (IEG) family, and arc (activity-regulated cytoskeleton-associated protein) expression.	Pentylenetetrazole	106-109	early growth response 1	Rattus norvegicus	152-156	
23744421-6	2013	RESULTS: When compared to animals that had been administered only a single PTZ injection (35 mg/kg), the animals at stage 5 of kindling had significantly higher Egr1 and Arc expression in the CA1 region of the hippocampus and the dentate gyrus.	Pentylenetetrazole	75-78	early growth response 1	Rattus norvegicus	161-165	
23744421-8	2013	The fastest and most potent increase in Egr1 expression during PTZ-induced kindling was found in the piriform and entorhinal cortices.	Pentylenetetrazole	63-66	early growth response 1	Rattus norvegicus	40-44	
8859016-1	1996	Metrazole, which reflexively activates the splanchnic nerve to the adrenal medulla, was used to investigate the physiological role of Egr-1 in the neural regulation of phenylethanolamine N-methyltransferase (PNMT) gene transcription in the rat adrenal gland.	Pentylenetetrazole	0-9	early growth response 1	Rattus norvegicus	134-139	
8859016-9	1996	Finally, splanchnic denervation partially blocked the metrazole-induced rise in Egr-1 mRNA (50% control), while having no effect on cocaine-induced changes in Egr-1 mRNA.	Pentylenetetrazole	54-63	early growth response 1	Rattus norvegicus	80-85	
9375653-6	1997	Administration of the convulsants NMDA, kainate, and pentylenetetrazole differentially induced Egr-1 and Egr-2/3 DNA-binding activities in the cerebral cortex, hippocampus, and cerebellum.	Pentylenetetrazole	53-71	early growth response 1	Rattus norvegicus	95-100	
1465218-3	1992	Administration of the convulsant, pentylenetetrazole (PTZ), caused a dramatic increase of c-fos and zif/268 mRNAs in the hippocampus and dentate gyrus.	Pentylenetetrazole	34-52	early growth response 1	Rattus norvegicus	100-107	
1465218-3	1992	Administration of the convulsant, pentylenetetrazole (PTZ), caused a dramatic increase of c-fos and zif/268 mRNAs in the hippocampus and dentate gyrus.	Pentylenetetrazole	54-57	early growth response 1	Rattus norvegicus	100-107	
1465218-4	1992	Pretreatment with caerulein suppressed the PTZ-induced c-fos and zif/268 expression.	Pentylenetetrazole	43-46	early growth response 1	Rattus norvegicus	65-72	
31279580-9	2019	Using this approach, we found that PTZ kindled rats did not differ from control rats in regards to exploratory behaviour, but there was a marked attenuation in behaviour-induced expression of Fos and Zif268 for rats that received 2 weeks of PTZ kindling.	Pentylenetetrazole	35-38	early growth response 1	Rattus norvegicus	200-206	
31279580-9	2019	Using this approach, we found that PTZ kindled rats did not differ from control rats in regards to exploratory behaviour, but there was a marked attenuation in behaviour-induced expression of Fos and Zif268 for rats that received 2 weeks of PTZ kindling.	Pentylenetetrazole	241-244	early growth response 1	Rattus norvegicus	200-206	
31279580-10	2019	Further examination revealed that PTZ kindled rats showed reduced colocalization of Fos and Zif268 in 2.5 week old BrdU + cells.	Pentylenetetrazole	34-37	early growth response 1	Rattus norvegicus	92-98	
31279580-11	2019	The proportion of immature granule cells (doublecortin-positive) expressing behaviorally induced Zif268 was also significantly lower for PTZ kindled rats than control rats.	Pentylenetetrazole	137-140	early growth response 1	Rattus norvegicus	97-103	
3174663-1	1988	Administration of the convulsants pentylenetetrazole (Metrazole) or picrotoxin to rats caused a dramatic increase in mRNAs of four putative transcription factor genes, zif/268, c-jun, jun-B, and c-fos, in neurons of the hippocampus and dentate gyrus, as well as other areas of the cerebral cortex, including pyriform cortex and cingulate cortex.	Pentylenetetrazole	34-52	early growth response 1	Rattus norvegicus	168-175	
3174663-1	1988	Administration of the convulsants pentylenetetrazole (Metrazole) or picrotoxin to rats caused a dramatic increase in mRNAs of four putative transcription factor genes, zif/268, c-jun, jun-B, and c-fos, in neurons of the hippocampus and dentate gyrus, as well as other areas of the cerebral cortex, including pyriform cortex and cingulate cortex.	Pentylenetetrazole	54-63	early growth response 1	Rattus norvegicus	168-175