PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31078073-0	2019	Interaction of sigma-1 receptor modulators with seizure development in pentylenetetrazole-induced kindled mice.	Pentylenetetrazole	71-89	sigma non-opioid intracellular receptor 1	Mus musculus	15-31	
34205384-2	2021	Studies have shown that activation of Sig1R, using the high affinity ligand (+)-pentazocine ((+)-PTZ), improves cone function in a severe retinopathy model.	Pentylenetetrazole	97-100	sigma non-opioid intracellular receptor 1	Mus musculus	38-43	
33385516-8	2021	Our results demonstrated that Sig1R-/- mice have decreased thresholds for PTZ- and BIC-induced tonic seizures.	Pentylenetetrazole	74-77	sigma non-opioid intracellular receptor 1	Mus musculus	30-35	
27298364-4	2016	Systemic administration of the high-affinity Sig1R ligand (+)-pentazocine [(+)-PTZ] to rd10 mice over several weeks led to the rescue of cone function as indicated by electroretinographic recordings using natural noise stimuli and preservation of cone cells upon spectral domain optical coherence tomography and retinal histological examination.	Pentylenetetrazole	75-82	sigma non-opioid intracellular receptor 1	Mus musculus	45-50	
28389336-5	2017	Sig1R antagonist NE-100 at a dose of 25mg/kg demonstrated pro-convulsive activity on PTZ-induced seizures.	Pentylenetetrazole	85-88	sigma non-opioid intracellular receptor 1	Mus musculus	0-5	
30743048-2	2019	Earlier studies showed that activation of Sig1R via the high-affinity ligand (+)-pentazocine ((+)-PTZ) induced profound rescue of cone photoreceptor cells in the rd10 mouse model of retinitis pigmentosa; however the mechanism of rescue is unknown.	Pentylenetetrazole	94-101	sigma non-opioid intracellular receptor 1	Mus musculus	42-47	
30743048-5	2019	Activation of Sig1R in 661W cone cells using (+)-PTZ induced dose-dependent increases in NRF2-ARE binding activity and NRF2 gene/protein expression, whereas silencing Sig1R significantly decreased NRF2 protein levels and increased oxidative stress, although (+)-PTZ did not disrupt NRF2-KEAP1 binding.	Pentylenetetrazole	45-52	sigma non-opioid intracellular receptor 1	Mus musculus	14-19	
30743048-5	2019	Activation of Sig1R in 661W cone cells using (+)-PTZ induced dose-dependent increases in NRF2-ARE binding activity and NRF2 gene/protein expression, whereas silencing Sig1R significantly decreased NRF2 protein levels and increased oxidative stress, although (+)-PTZ did not disrupt NRF2-KEAP1 binding.	Pentylenetetrazole	258-265	sigma non-opioid intracellular receptor 1	Mus musculus	14-19	
27298364-5	2016	The protective effect appears to result from the activation of Sig1R, because rd10/Sig1R(-/-) mice administered (+)-PTZ exhibited no cone preservation.	Pentylenetetrazole	116-119	sigma non-opioid intracellular receptor 1	Mus musculus	63-68	
25439327-1	2015	The high-affinity sigma receptor 1 (sigmaR1) ligand (+)-pentazocine ((+)-PTZ) affords profound retinal neuroprotection in vitro and in vivo by a yet-unknown mechanism.	Pentylenetetrazole	69-76	sigma non-opioid intracellular receptor 1	Mus musculus	36-43	
23233788-2	2012	Ligands for sigmaR1, such as (+)-pentazocine [(+)-PTZ], confer marked retinal neuroprotection in vivo and in vitro.	Pentylenetetrazole	46-53	sigma non-opioid intracellular receptor 1	Mus musculus	12-19	
23233788-13	2012	CONCLUSIONS: This is the first report showing unequivocally that the neuroprotective effects of (+)-PTZ require sigmaR1.	Pentylenetetrazole	96-103	sigma non-opioid intracellular receptor 1	Mus musculus	112-119	
17898305-2	2007	Previously, the authors induced death in the RGC-5 cell line using very high concentrations (1 mM) of the excitatory amino acids glutamate (Glu) and homocysteine (Hcy) and demonstrated that the sigmaR1 ligand (+)-pentazocine ((+)-PTZ) could protect against cell death.	Pentylenetetrazole	226-233	sigma non-opioid intracellular receptor 1	Mus musculus	194-201	
17898305-14	2007	The stereoselective effect of (+)-PTZ for sigmaR1 was established in experiments in which (-)-PTZ, the levo-isomer form of pentazocine, had no neuroprotective effect on excitotoxin-induced ganglion cell death.	Pentylenetetrazole	30-37	sigma non-opioid intracellular receptor 1	Mus musculus	42-49