PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23036853-3 2013 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a potent AhR ligand has not been shown to form any DNA adduct, but has a possibility to aggravate the toxicity of precarcinogenic polycyclic hydrocarbons through the induction of metabolic enzymes. Hydrocarbons 185-197 aryl hydrocarbon receptor Homo sapiens 53-56 22311706-1 2012 The aryl hydrocarbon receptor (AhR), a ligand-activated member of the basic helix-loop-helix (bHLH)/PER-ARNT-SIM (PAS) transcription superfamily, is known to regulate the toxicity of polyaromatic halogenated hydrocarbon environmental chemicals, most notably dioxin. Hydrocarbons 9-20 aryl hydrocarbon receptor Homo sapiens 31-34 18546721-14 2008 The tested PAHs accounted for < 1% of the total AHR-mediated response, indicating that considerable amounts of other aryl hydrocarbons must be present in filtered and unfiltered exhaust. Hydrocarbons 125-137 aryl hydrocarbon receptor Homo sapiens 51-54 11032419-1 2000 Aryl hydrocarbon receptor (AhR), a member of the bHLH-PAS family, is a ligand-activated transcription factor which plays an important role in normal liver development and in mediating the toxicity of polycyclic and halogenated aromatic hydrocarbon pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin. Hydrocarbons 5-16 aryl hydrocarbon receptor Homo sapiens 27-30 17012224-3 2007 Many AHR agonists, like the polyaromatic hydrocarbons and polyhalogenated hydrocarbons are known human carcinogens. Hydrocarbons 41-53 aryl hydrocarbon receptor Homo sapiens 5-8 16902966-3 2006 One example of this is the aryl hydrocarbon receptor (AHR), a basic-helix-loop-helix (bHLH)-Per-Arnt-Sim (PAS) transcription factor through which planar aromatic hydrocarbons cause altered gene expression and toxicity. Hydrocarbons 162-174 aryl hydrocarbon receptor Homo sapiens 27-52 16902966-3 2006 One example of this is the aryl hydrocarbon receptor (AHR), a basic-helix-loop-helix (bHLH)-Per-Arnt-Sim (PAS) transcription factor through which planar aromatic hydrocarbons cause altered gene expression and toxicity. Hydrocarbons 162-174 aryl hydrocarbon receptor Homo sapiens 54-57 15475306-5 2004 In addition to these elements, the CYP6B4 and CYP6B1 promoters also contain putative XRE-AhR elements identical to the aryl hydrocarbon response elements present in mammalian phase I detoxification genes. Hydrocarbons 124-135 aryl hydrocarbon receptor Homo sapiens 89-92 12972062-1 2003 Aryl hydrocarbons such as dioxins, polychlorinated biphenyls and polyaromatic hydrocarbons bind to the cellular aryl hydrocarbon receptor (AhR) in the initial step of their metabolism. Hydrocarbons 5-17 aryl hydrocarbon receptor Homo sapiens 139-142 8125016-4 1994 This mapping data should prove useful in determining the role that the AHR locus plays in human cancer incidence and in the identification of human populations with altered susceptibilities to the toxic/carcinogenic effects of planar aromatic hydrocarbons. Hydrocarbons 243-255 aryl hydrocarbon receptor Homo sapiens 71-74 31849690-4 2019 In this pathological process, PM2.5 particles, excessive reactive oxygen species (ROS) derived from PM2.5, and certain components in PM2.5, such as ions and polyaromatic hydrocarbons (PAHs), have been implicated as potential EMT mediators that are linked to the activation of transforming growth factor beta (TGF-beta)/SMADs, NF-kappaB, growth factor (GF)/extracellular signal-regulated protein kinase (ERK), GF/phosphatidylinositol 3-kinase (PI3K)/Akt, wingless/integrated (Wnt)/beta-catenin, Notch, Hedgehog, high mobility group box B1 (HMGB1)-receptor for advanced glycation end-products (RAGE), and aryl hydrocarbon receptor (AHR) signaling cascades and to cytoskeleton rearrangement. Hydrocarbons 184-188 aryl hydrocarbon receptor Homo sapiens 603-628 31849690-4 2019 In this pathological process, PM2.5 particles, excessive reactive oxygen species (ROS) derived from PM2.5, and certain components in PM2.5, such as ions and polyaromatic hydrocarbons (PAHs), have been implicated as potential EMT mediators that are linked to the activation of transforming growth factor beta (TGF-beta)/SMADs, NF-kappaB, growth factor (GF)/extracellular signal-regulated protein kinase (ERK), GF/phosphatidylinositol 3-kinase (PI3K)/Akt, wingless/integrated (Wnt)/beta-catenin, Notch, Hedgehog, high mobility group box B1 (HMGB1)-receptor for advanced glycation end-products (RAGE), and aryl hydrocarbon receptor (AHR) signaling cascades and to cytoskeleton rearrangement. Hydrocarbons 184-188 aryl hydrocarbon receptor Homo sapiens 630-633 31695491-1 2019 Background: TIPARP (TCDD-inducible poly-ADP-ribose polymerase), a mono-ADP-ribosyltransferase and a transcriptional repressor of aryl hydrocarbon receptor (AHR), was one of the potential therapeutic targets for human cancers identified by CRISPR-Cas9 screens recently. Hydrocarbons 129-145 aryl hydrocarbon receptor Homo sapiens 156-159 9698073-8 1998 These results suggest that the chemopreventive effect of curcumin may be due, in part, to its ability to compete with aryl hydrocarbons for both the AhR and CYP1A1. Hydrocarbons 123-135 aryl hydrocarbon receptor Homo sapiens 149-152 9717460-3 1998 Polycyclic aromatic hydrocarbons regulate the gene expression by binding the cytosolic aryl hydrocarbon receptor and its translocation to the nucleus where it forms a ternary complex with aryl hydrocarbon nuclear translocator. Hydrocarbons 20-31 aryl hydrocarbon receptor Homo sapiens 87-112 9717460-4 1998 The ternary complex PAH-AHR-ARNT acts as a transcription factor and binds aromatic hydrocarbon responsive element to increase the expression of CYP1A1 gene. Hydrocarbons 83-94 aryl hydrocarbon receptor Homo sapiens 24-27 9599728-1 1998 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is the most potent member of a class of chlorinated hydrocarbons that interact with the aryl hydrocarbon receptor (AhR). Hydrocarbons 95-107 aryl hydrocarbon receptor Homo sapiens 131-156 9599728-1 1998 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is the most potent member of a class of chlorinated hydrocarbons that interact with the aryl hydrocarbon receptor (AhR). Hydrocarbons 95-107 aryl hydrocarbon receptor Homo sapiens 158-161 32790354-4 2020 The aryl hydrocarbon (AhR) and pregnane X (PXR) transcription factors showed the greatest upregulation; with HLB exceeding DCM-total, and no upregulation in the hydrocarbon fraction (DCM-SGC). Hydrocarbons 9-20 aryl hydrocarbon receptor Homo sapiens 22-25