PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1692256-9	1990	Our observations indicate that, although AHH induction was genetically determined in each strain, activity can be induced in hepatocytes of so-called nonresponsive as well as responsive mouse strains by treatment with aromatic hydrocarbons after transfer of the cells to primary culture.	Hydrocarbons	227-239	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	41-44	
11163336-4	2001	2,3,7,8-Tetrachlorodibenzo-p-dioxin (dioxin; TCDD) is known to activate Cyp1a1 gene transcription by way of aromatic hydrocarbon response elements (AHREs).	Hydrocarbons	117-128	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	72-78	
20930378-6	2010	The present observations suggest the need to reveal the mechanism by which CYP1A1 expression is modified by flavonoids for risk assessment, since CYP1A1 activates environmental carcinogenic polycyclic hydrocarbons and flavonoids are major constituents in food.	Hydrocarbons	201-213	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	75-81	
6690048-1	1984	In mice, there is a correlation between genetically regulated levels of inducible aryl hydrocarbon hydroxylase (AHH) activity and the risk of polycyclic hydrocarbon-induced leukemia or solid tumors.	Hydrocarbons	87-98	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	112-115	
106274-9	1979	AR and MC are very good inducers of AHH activity in livers of mice classified as aromatic hydrocarbon responsive, but not in those classified as hydrocarbon nonresponsive.	Hydrocarbons	90-101	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	36-39	
7460072-9	1981	The 5--10-fold difference between cells from responsive and non-responsive mice in concentration of 3-MC needed to induce AHH maximally is taken to indicate that genes controlling aromatic hydrocarbon responsiveness in adult mouse livers in vivo also function in fetal mouse liver cells maintained in culture.	Hydrocarbons	189-200	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	122-125	
20930378-6	2010	The present observations suggest the need to reveal the mechanism by which CYP1A1 expression is modified by flavonoids for risk assessment, since CYP1A1 activates environmental carcinogenic polycyclic hydrocarbons and flavonoids are major constituents in food.	Hydrocarbons	201-213	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	146-152	
11577022-4	2001	Although Cyp1a1 was inducible in Ahr(+/+) by 3 micromol/L benzo(a)pyrene, a known hydrocarbon inducer, the protein was uninducible.	Hydrocarbons	82-93	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	9-15	
14720319-7	2004	Significantly, gene expression of CYP1A1 and 1B1 is induced by PAHs and polyhalogenated hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin through the arylhydrocarbon receptor.	Hydrocarbons	88-100	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	34-48