PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33123123-8 2020 Furthermore, MPI effector cells could likewise engulf RAW-ASC target cell corpses elicited by treatment with staurosporine (apoptosis), LPS, and nigericin (pyroptosis), or cSiO2. Nigericin 145-154 steroid sulfatase Mus musculus 54-61 31616405-6 2019 Following priming with LPS, both the canonical activator nigericin and cSiO2 elicited robust inflammasome activation in RAW-ASC cells, as reflected by IL-1beta release and caspase-1 activation. Nigericin 57-66 steroid sulfatase Mus musculus 120-127 31936823-6 2020 Importantly, we observed that IL-37 suppresses nigericin- and silica-induced ASC oligomerization/speck formation (a step in inflammasome activation and subsequent caspase-1 activation), and pyroptosis (-50%). Nigericin 47-56 steroid sulfatase Mus musculus 77-80 32733353-9 2020 Nigericin administration enhanced ASC oligomerization, caspase-1 and IL-1beta maturation without increasing the protein level of NLRP3, and ASC oligomerization and caspase-1 IL-1beta maturation reduced when combined with NEK7 knockdown or MCC950 delivery. Nigericin 0-9 steroid sulfatase Mus musculus 34-37 30761140-3 2019 Here we showed that paclitaxel pre-treatment greatly enhanced ATP- or nigericin-induced NLRP3 inflammasome activation as indicated by increased release of cleaved caspase-1 and mature IL-1beta, enhanced formation of ASC speck, and increased gasdermin D cleavage and pyroptosis. Nigericin 70-79 steroid sulfatase Mus musculus 216-219 29863661-12 2018 In this manuscript, we show that activation of the NLRP3 inflammasome by nigericin leads to the co-localization of the adaptor protein ASC and active caspase-1, leading to pyroptosis. Nigericin 73-82 steroid sulfatase Mus musculus 135-138