PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23597448-5 2013 I3C also suppressed IL-1beta secretion in nigericin treated in vivo model. Nigericin 42-51 interleukin 1 beta Mus musculus 20-28 11399517-9 2001 In addition, nigericin markedly enhanced the release of IL-1 beta in unprimed mice but not in macrophages from IFN-gamma primed mice. Nigericin 13-22 interleukin 1 beta Mus musculus 56-65 22327078-4 2012 Treatment with nigericin during influenza infection augmented IL-1beta production, increased caspase-1 activity, and decreased morbidity and mortality in elderly mice. Nigericin 15-24 interleukin 1 beta Mus musculus 62-70 21048113-5 2010 Similarly with ATP, knockdown of TRIM30 increased caspase-1 activation and IL-1beta production triggered by other NLRP3 inflammasome agonists, including nigericin, monosodium urate, and silica. Nigericin 153-162 interleukin 1 beta Mus musculus 75-83 21437011-8 2010 The secretion of IL-1beta was also increased by nigericin in WT mice and the secretory effect of a combination of ivermectin with ATP in KO mice was suppressed in a medium containing a high concentration of potassium. Nigericin 48-57 interleukin 1 beta Mus musculus 17-25 17121814-0 2007 Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway. Nigericin 38-47 interleukin 1 beta Mus musculus 56-73 17121814-4 2007 We have pursued this hypothesis by measuring dye uptake and IL-1beta processing and release in mouse J774 macrophage in response to P2X7R activation and to maitotoxin and nigericin, two agents considered to evoke IL-1beta release via the same mechanism. Nigericin 171-180 interleukin 1 beta Mus musculus 60-68 17121814-10 2007 Thus, although pannexin-1 is required for IL-1beta release in response to maitotoxin, nigericin, and ATP, a mechanism distinct from pannexin-1 hemichannel activation must underlie the former two processes. Nigericin 86-95 interleukin 1 beta Mus musculus 42-50 15075209-4 2004 In contrast, brief (5 min) treatment of intact macrophages with extracellular ATP (as an activator of the P2X(7) receptor) or nigericin before cell lysis markedly accelerated the in vitro processing of caspase-1 and IL-1beta. Nigericin 126-135 interleukin 1 beta Mus musculus 216-224 11016935-5 2001 Nigericin, an alternate secretion stimulus, promotes release of 17-kDa IL-1 beta from P2X(7)R(-/-) macrophages. Nigericin 0-9 interleukin 1 beta Mus musculus 71-80 8195155-0 1994 Interleukin-1 beta maturation and release in response to ATP and nigericin. Nigericin 65-74 interleukin 1 beta Mus musculus 0-18 9651388-4 1998 269, 15195-15203) reported that potassium depletion of lipopolysaccharide-stimulated mouse macrophages induced by the potassium ionophore, nigericin, leads to the rapid release of mature interleukin-1beta (IL-1beta). Nigericin 139-148 interleukin 1 beta Mus musculus 187-204 9651388-4 1998 269, 15195-15203) reported that potassium depletion of lipopolysaccharide-stimulated mouse macrophages induced by the potassium ionophore, nigericin, leads to the rapid release of mature interleukin-1beta (IL-1beta). Nigericin 139-148 interleukin 1 beta Mus musculus 206-214 8195155-3 1994 The potassium-proton ionophore nigericin and ATP are known to promote the maturation and release of IL-1 beta from LPS-stimulated cells. Nigericin 31-40 interleukin 1 beta Mus musculus 100-109 8195155-5 1994 Like nigericin, the ionophores A204 and lasalocid induced the release and maturation of IL-1 beta. Nigericin 5-14 interleukin 1 beta Mus musculus 88-97 8195155-13 1994 ADP was less active than ATP at initiating the post-translational maturation and release of IL-1 beta and AMP, GTP, and UTP were totally inactive, ATP, nigericin, A204, and lasalocid promoted a rapid and complete loss of the potassium analog 86Rb+ from cells that were preloaded with this cation; valinomycin-treated cells released only a portion of the radiolabeled cation. Nigericin 152-161 interleukin 1 beta Mus musculus 92-101 8195155-16 1994 These data suggest that ATP and nigericin induce a net decrease in intracellular levels of K+ which is necessary for activation of the post-translational maturation of IL-1 beta. Nigericin 32-41 interleukin 1 beta Mus musculus 168-177 1500719-0 1992 IL-1 beta maturation: evidence that mature cytokine formation can be induced specifically by nigericin. Nigericin 93-102 interleukin 1 beta Mus musculus 0-9 1500719-6 1992 Importantly, incubation of the murine macrophages with the potassium/proton ionophore nigericin led to a quantitative conversion of pro-IL-1 beta to a 17-kDa species. Nigericin 86-95 interleukin 1 beta Mus musculus 136-145 1500719-7 1992 The N-terminus of this nigericin-derived product possessed the amino acid sequence expected for mature biologically active IL-1 beta. Nigericin 23-32 interleukin 1 beta Mus musculus 123-132 1500719-9 1992 Complete release of mature IL-1 beta required concentrations of nigericin in excess of 2 microM and a minimum of 10 min of treatment. Nigericin 64-73 interleukin 1 beta Mus musculus 27-36 1500719-10 1992 Mature 17-kDa IL-1 beta was observed within the nigericin-treated cells before their lysis. Nigericin 48-57 interleukin 1 beta Mus musculus 14-23 1500719-11 1992 Nigericin"s effect was not limited to mouse peritoneal macrophages, inasmuch as the ionophore also induced release and proteolytic maturation of IL-1 beta produced by LPS-stimulated human peripheral blood monocytes. Nigericin 0-9 interleukin 1 beta Mus musculus 145-154 1500719-12 1992 Treatment of macrophages with LPS and nigericin, therefore, results in a unique series of intracellular events that promote formation of mature 17-kDa IL-1 beta. Nigericin 38-47 interleukin 1 beta Mus musculus 151-160 31616405-6 2019 Following priming with LPS, both the canonical activator nigericin and cSiO2 elicited robust inflammasome activation in RAW-ASC cells, as reflected by IL-1beta release and caspase-1 activation. Nigericin 57-66 interleukin 1 beta Mus musculus 151-159 31616405-11 2019 DHA pre-incubation suppressed inflammasome activation and release of IL-1beta and IL-1alpha by nigericin, cSiO2, and two other crystals - monosodium urate and alum. Nigericin 95-104 interleukin 1 beta Mus musculus 69-77 31336157-10 2019 Coptisine significantly attenuated mature interleukin (IL)-1beta secretion in RAW264.7 macrophages stimulated with LPS plus ATP, nigericin, or MSU, by blocking caspase-1 activation. Nigericin 129-138 interleukin 1 beta Mus musculus 42-64 27543123-4 2016 Using the inflammasome protocol, exposure of cardiomyocytes (CMs) to LPS followed by ATP or nigericin caused release of mature IL-1beta. Nigericin 92-101 interleukin 1 beta Mus musculus 127-135 30761140-3 2019 Here we showed that paclitaxel pre-treatment greatly enhanced ATP- or nigericin-induced NLRP3 inflammasome activation as indicated by increased release of cleaved caspase-1 and mature IL-1beta, enhanced formation of ASC speck, and increased gasdermin D cleavage and pyroptosis. Nigericin 70-79 interleukin 1 beta Mus musculus 184-192 28855315-10 2017 Concerning the second triggering factors, ROS production and ATP- and nigericin-induced IL1b secretion were suppressed by eplerenone in the LPS-primed BMDM. Nigericin 70-79 interleukin 1 beta Mus musculus 88-92 25472006-8 2015 Treatment of DBA/2 susceptible mice with inflammasome inducers (i.e. nigericin and ATP) artificially increased pyroptosis and lowered the levels of NF-kappaB-related inflammatory cytokines, but restored IL-1beta to levels similar to those in C57BL/6 mice. Nigericin 69-78 interleukin 1 beta Mus musculus 203-211 26100631-3 2015 Sustained stimulation (>2 h) of LPS-primed caspase-1-deficient (Casp1/11(-/-)) BMDC with the canonical NLRP3 inflammasome agonist nigericin results in release of bioactive IL-1beta in conjunction with robust caspase-8 activation. Nigericin 133-142 interleukin 1 beta Mus musculus 175-183 26091541-6 2015 Microglia were able to produce IL-1beta in response to different classical inflammasome activators, such as ATP, Nigericin or Alum. Nigericin 113-122 interleukin 1 beta Mus musculus 31-39 25867480-5 2015 Emodin treatment attenuated interleukin (IL)-1beta secretion via the inhibition of NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation induced by ATP, nigericin, and silica crystals. Nigericin 183-192 interleukin 1 beta Mus musculus 28-50