PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30404814-7 2018 LPS or nigericin stimulation of PLAC8-overexpressing human monocytic cell line (THP-1), but not mock THP-1 cells, was associated with a significant decrease in IL-1beta and IL-18 production. Nigericin 7-16 interleukin 1 beta Homo sapiens 160-168 30513737-9 2018 Moreover, this strong reduction of pro-inflammatory IL-1beta is associated with a decrease of NLRP3 and, in J774A, ASC protein expression, which depends on the choice of activator ATP or nigericin. Nigericin 187-196 interleukin 1 beta Homo sapiens 52-60 30555323-11 2018 In LPS-primed THP-1 cells stimulated by nigericin (a model to study the NLRP3 inflammasome), rifaximin reduced IL-1beta production in a concentration-dependent fashion, this effect being associated with inhibition of the up-stream caspase-1 activation. Nigericin 40-49 interleukin 1 beta Homo sapiens 111-119 29479354-7 2018 To further understand the differential expression of cytokines/chemokines, we showed that WFA alters the nigericin-induced co-localization of NLRP3 and ASC proteins, thereby inhibiting caspase-1 activation, which is responsible for the cleavage and maturation of pro-inflammatory cytokines IL-1beta and IL-18. Nigericin 105-114 interleukin 1 beta Homo sapiens 290-298 29263464-12 2017 We also found that downregulation of ATG5 and Beclin1 sensitized cells for the release of IL-1beta induced by MSU (monosodium urate) or nigericin which was the NLRP3 inflammasome activator. Nigericin 136-145 interleukin 1 beta Homo sapiens 90-98 26825654-6 2016 Furthermore, we observed that ATG5 and Beclin1 downregulation sensitised cells to IL-1beta release induced by MSU or nigericin, which is an NLRP3 inflammasome activator. Nigericin 117-126 interleukin 1 beta Homo sapiens 82-90 29056256-6 2017 Treatment with either LPS or nigericin stimulated IL-1beta secretion, whereas pretreatment with the ATP-sensitive K+ channel inhibitor glibenclamide, the Rho-associated coiled-coil kinase inhibitor Y-27632, or a caspase-1 inhibitor significantly decreased nigericin-induced IL-1beta secretion. Nigericin 29-38 interleukin 1 beta Homo sapiens 50-58 29056256-6 2017 Treatment with either LPS or nigericin stimulated IL-1beta secretion, whereas pretreatment with the ATP-sensitive K+ channel inhibitor glibenclamide, the Rho-associated coiled-coil kinase inhibitor Y-27632, or a caspase-1 inhibitor significantly decreased nigericin-induced IL-1beta secretion. Nigericin 29-38 interleukin 1 beta Homo sapiens 274-282 28516117-4 2016 Here, we describe how to co-transfect the NLRP3 inflammasome components into HEK293T cells, which enables inflammasome activation and the production of IL-1beta upon stimulation with nigericin. Nigericin 183-192 interleukin 1 beta Homo sapiens 152-160 26559977-10 2015 Finally, using small molecule inhibitors, it was demonstrated that both calcium and calmodulin were required for nigericin-induced IL-1beta secretion in THP-1 cells and primary human monocytes. Nigericin 113-122 interleukin 1 beta Homo sapiens 131-139 26267804-4 2015 We showed that decrease in either UCH-L5 activity, or in UCH-L5 protein amount in chicken and human macrophages infected or stimulated with LPS/nigericin, led to decreased IL-1beta release. Nigericin 144-153 interleukin 1 beta Homo sapiens 172-180 26398903-5 2015 This work also found that PRRSV nonstructural protein (nsp) 11 could inhibit the expression of pro-IL-1beta mRNA induced by lipopolysaccharide (LPS) and the secretion of IL-1beta induced by LPS plus nigericin in PAMs. Nigericin 199-208 interleukin 1 beta Homo sapiens 170-178 24238269-7 2014 However, levels of extracellular IL-1beta were greatly increased by subsequent treatment with the potassium-proton ionophore Adenosine triphosphate (ATP) or nigericin; an effect that was dependent on active caspase-1. Nigericin 157-166 interleukin 1 beta Homo sapiens 33-41 25054228-13 2014 Glioblastoma IL-1beta processing occurred by the NLRP3 inflammasome, and ATP and nigericin increased IL-1beta processing by upregulating NLRP3 expression, similar to macrophages. Nigericin 81-90 interleukin 1 beta Homo sapiens 101-109 24238269-8 2014 Additionally, ATP induced IL-1beta secretion via the purinergic P2X7 receptor, whereas the pannexin-1 channel was required for nigericin induced IL-1beta secretion. Nigericin 127-136 interleukin 1 beta Homo sapiens 145-153 24244322-4 2013 RESULTS: Ethanol decreased dose-dependently the production of mature IL-1beta induced by activators of the NLRP3 inflammasome, i.e. ATP, cholesterol crystals, serum amyloid A and nigericin. Nigericin 179-188 interleukin 1 beta Homo sapiens 69-77 24006511-6 2013 In addition, they totally prevented the IL-1beta release induced by SFAs and, with less efficiency, by a broad range of NLRP3 inducers, including nigericin, alum, and monosodium urate. Nigericin 146-155 interleukin 1 beta Homo sapiens 40-48 23253918-10 2013 Indeed, NLRP3 inflammasome agonists such as uric acid crystal or nigericin induce IL-1alpha cleavage and secretion, leading to the cosecretion of both IL-1beta and IL-1alpha. Nigericin 65-74 interleukin 1 beta Homo sapiens 151-159 9770325-2 1998 Since the precursor form of interleukin-1beta (pre-IL-1beta) is one of the well known substrates for ICE, and a potassium/proton ionophore, nigericin, enhances IL-1beta processing, the authors hypothesized that nigericin induces apoptosis through the activation of ICE. Nigericin 140-149 interleukin 1 beta Homo sapiens 51-59 19130485-8 2009 TPEN did however inhibit the activity of pannexin-1, a hemi-channel critical for adenosine triphosphate and nigericin-induced IL-1beta release. Nigericin 108-117 interleukin 1 beta Homo sapiens 126-134 12934070-1 2003 The potassium ionophore nigericin induces cell death and promotes the maturation and release of IL-1beta in lipopolysaccharide (LPS)-primed monocytes and macrophages, the latter depending on caspase-1 activation by an unknown mechanism. Nigericin 24-33 interleukin 1 beta Homo sapiens 96-104 18523309-7 2008 Nigericin, a K(+)/H(+) antiporter, also increases NADPH oxidase activity, leading to IL-1beta and caspase-1 processing that is blocked by a peroxynitrite scavenger or inhibition of NADPH oxidase. Nigericin 0-9 interleukin 1 beta Homo sapiens 85-93 15004138-7 2004 Incubation of monocytes of either genotype with nigericin resulted in a similar release of IL-1beta. Nigericin 48-57 interleukin 1 beta Homo sapiens 91-99 9770325-2 1998 Since the precursor form of interleukin-1beta (pre-IL-1beta) is one of the well known substrates for ICE, and a potassium/proton ionophore, nigericin, enhances IL-1beta processing, the authors hypothesized that nigericin induces apoptosis through the activation of ICE. Nigericin 140-149 interleukin 1 beta Homo sapiens 160-168 9770325-2 1998 Since the precursor form of interleukin-1beta (pre-IL-1beta) is one of the well known substrates for ICE, and a potassium/proton ionophore, nigericin, enhances IL-1beta processing, the authors hypothesized that nigericin induces apoptosis through the activation of ICE. Nigericin 211-220 interleukin 1 beta Homo sapiens 28-45 9770325-4 1998 Under exactly the same conditions, nigericin also induced IL-1beta processing in these cells, which was significantly inhibited by an ICE inhibitor, acetyl-Tyr-Val-Ala-Asp-CHO. Nigericin 35-44 interleukin 1 beta Homo sapiens 58-66 9651388-0 1998 Increased mature interleukin-1beta (IL-1beta) secretion from THP-1 cells induced by nigericin is a result of activation of p45 IL-1beta-converting enzyme processing. Nigericin 84-93 interleukin 1 beta Homo sapiens 17-34 9651388-0 1998 Increased mature interleukin-1beta (IL-1beta) secretion from THP-1 cells induced by nigericin is a result of activation of p45 IL-1beta-converting enzyme processing. Nigericin 84-93 interleukin 1 beta Homo sapiens 36-44 9651388-6 1998 Rapid secretion of mature, 17-kDa IL-1beta occurred, in the presence of nigericin (4-16 microM). Nigericin 72-81 interleukin 1 beta Homo sapiens 34-42 9651388-8 1998 Addition of the irreversible interleukin-1beta-converting enzyme (ICE) inhibitor, Z-Val-Ala-Asp-dichlorobenzoate, or a radicicol analog, inhibited nigericin-induced mature IL-1beta release and activation of p45 ICE precursor. Nigericin 147-156 interleukin 1 beta Homo sapiens 172-180 9651388-11 1998 We have therefore shown conclusively, for the first time, that nigericin-induced release of IL-1beta is dependent upon activation of p45 ICE processing. Nigericin 63-72 interleukin 1 beta Homo sapiens 92-100 34872043-5 2021 1,25(OH)2VD3 suppressed nigericin-induced interleukin-1beta (IL-1beta) secretion and caspase-1 activation in human primary keratinocytes. Nigericin 24-33 interleukin 1 beta Homo sapiens 42-59 31707353-5 2020 A decreased expression of IL-1beta was observed in both G6PD-deficient PBMCs and PMA-primed G6PD-knockdown (G6PD-kd) THP-1 cells upon lipopolysaccharide (LPS)/adenosine triphosphate (ATP) or LPS/nigericin stimulation. Nigericin 195-204 interleukin 1 beta Homo sapiens 26-34 31086288-7 2019 Basal IL-1beta secretion increased from 584 to 2696 pg/mL (P < 0.01) in nigericin-activated macrophages; forskolin dose-dependently reduced the nigericin-induced secretion of mature IL-1beta (P < 0.01). Nigericin 75-84 interleukin 1 beta Homo sapiens 6-14 31086288-7 2019 Basal IL-1beta secretion increased from 584 to 2696 pg/mL (P < 0.01) in nigericin-activated macrophages; forskolin dose-dependently reduced the nigericin-induced secretion of mature IL-1beta (P < 0.01). Nigericin 147-156 interleukin 1 beta Homo sapiens 6-14 31086288-7 2019 Basal IL-1beta secretion increased from 584 to 2696 pg/mL (P < 0.01) in nigericin-activated macrophages; forskolin dose-dependently reduced the nigericin-induced secretion of mature IL-1beta (P < 0.01). Nigericin 147-156 interleukin 1 beta Homo sapiens 185-193 31019507-7 2019 In contrast, the ATP-independent IL-1beta release induced by the pore forming bacterial toxin nigericin is not impaired, and SLPI does not directly modulate the ion channel function of the human P2X7 receptor heterologously expressed in Xenopus laevis oocytes. Nigericin 94-103 interleukin 1 beta Homo sapiens 33-41 30804327-6 2019 NLRP3 inflammasome activation by the bacterial toxin nigericin led to the proinflammatory interleukin-1beta (IL-1beta) release and to the induction of cell death by pyroptosis. Nigericin 53-62 interleukin 1 beta Homo sapiens 90-107 30804327-6 2019 NLRP3 inflammasome activation by the bacterial toxin nigericin led to the proinflammatory interleukin-1beta (IL-1beta) release and to the induction of cell death by pyroptosis. Nigericin 53-62 interleukin 1 beta Homo sapiens 109-117 31086288-4 2019 RESULTS: Activation of THP-1 macrophages with nigericin increased the mRNA expression of NLRP3, IL-1beta, and caspase-1 (P < 0.01). Nigericin 46-55 interleukin 1 beta Homo sapiens 96-104 31281309-5 2019 The treatment of macrophages with PDL-sup, but not PDL-sup from unstimulated PDL cells, inhibited the production of IL-1beta in LPS/nigericin-stimulated macrophages. Nigericin 132-141 interleukin 1 beta Homo sapiens 116-124 31281309-9 2019 Purified exosomes inhibited IL-1beta production in LPS/nigericin-stimulated macrophages and the nuclear translocation of NF-kappaB as well as NF-kappaB p65 DNA-binding activity in LPS-stimulated macrophages, suggesting that exosomes suppress IL-1beta production by inhibiting the NF-kappaB signaling pathway. Nigericin 55-64 interleukin 1 beta Homo sapiens 28-36