PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33830232-4	2021	ACA inhibited Caspase-1 activation and IL-1beta production by NLRP3 agonists such as nigericin, monosodium urate (MSU) crystals, and ATP.	Nigericin	85-94	interleukin 1 alpha	Mus musculus	39-47	
33909257-5	2021	Bavachin boosts the secretion of IL-1beta and caspase-1 caused by ATP or nigericin but not those induced by poly(I:C), monosodium urate crystal, or intracellular lipopolysaccharide.	Nigericin	73-82	interleukin 1 alpha	Mus musculus	33-41	
34861244-13	2022	In vitro, MaR1 could significantly suppressed the expression of NLR family pyrin domain containing 3 (NLRP3) inflammasome, GSDMD-N, and IL-1beta caused by LPS and nigericin stimulation in BMDMs.	Nigericin	163-172	interleukin 1 alpha	Mus musculus	136-144	
35436667-7	2022	Among this series, compound 13a exhibited the most potent cellular NLRP3 inhibitory effect with an IC50 value of 49 nM, and significantly suppressed LPS/Nigericin-induced secretion of active caspase-1 and mature IL-1beta in a dose-dependent manner to block the activation of NLRP3 inflammasome.	Nigericin	153-162	interleukin 1 alpha	Mus musculus	212-220	
31616405-11	2019	DHA pre-incubation suppressed inflammasome activation and release of IL-1beta and IL-1alpha by nigericin, cSiO2, and two other crystals - monosodium urate and alum.	Nigericin	95-104	interleukin 1 alpha	Mus musculus	82-91	
33440601-5	2021	Ac2-26 administration reduced NLRP3-derived IL-1beta production by WT neutrophils after nigericin and ATP stimulation.	Nigericin	88-97	interleukin 1 alpha	Mus musculus	44-52	
32733353-9	2020	Nigericin administration enhanced ASC oligomerization, caspase-1 and IL-1beta maturation without increasing the protein level of NLRP3, and ASC oligomerization and caspase-1 IL-1beta maturation reduced when combined with NEK7 knockdown or MCC950 delivery.	Nigericin	0-9	interleukin 1 alpha	Mus musculus	69-77