PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31086288-3	2019	METHODS: The proteins and messenger RNA (mRNA) levels of inflammasome structural proteins and proinflammatory cytokines were measured in forskolin-stimulated nigericin-activated human THP-1 macrophages and primary macrophages.	Nigericin	158-167	GLI family zinc finger 2	Homo sapiens	184-189	
31086288-4	2019	RESULTS: Activation of THP-1 macrophages with nigericin increased the mRNA expression of NLRP3, IL-1beta, and caspase-1 (P < 0.01).	Nigericin	46-55	GLI family zinc finger 2	Homo sapiens	23-28	
23226468-13	2012	A1PI-M co-localized with caspase-1 in gel-filtered cytoplasmic THP-1 preparations, and was co-immunoprecipitated with caspase 1 from nigericin-stimulated THP-1 cell lysate.	Nigericin	133-142	GLI family zinc finger 2	Homo sapiens	154-159	
9770325-3	1998	In a lipopolysaccharide (LPS)-stimulated and nigericin-treated human monocytic cell line, THP-1, apoptosis was induced, as assessed as to a decrease in cell size, chromatin condensation, exposure of phosphatidylserine and DNA fragmentation.	Nigericin	45-54	GLI family zinc finger 2	Homo sapiens	90-95	
32374168-3	2020	CBD (0.1, 1, and 10 muM) exerted anti-inflammasome activity in LPS-nigericin-stimulated THP-1 monocytes by reducing media IL-1beta concentration (by 63.9%, 64.1%, and 83.1%, respectively), which was similar to the known NLRP3 inflammasome inhibitors oridonin and MCC950 (16.9% vs 20.8% and 17.4%, respectively; at 10 muM).	Nigericin	67-76	GLI family zinc finger 2	Homo sapiens	88-93	
32374168-4	2020	CBD (10 muM) decreased nigericin-alone- and nigericin-lipopolysaccharide-induced potassium efflux by 13.7% and 13.0%, respectively, in THP-1 monocytes, strongly suggesting P2X7 receptor modulation.	Nigericin	44-53	GLI family zinc finger 2	Homo sapiens	135-140	
30735689-3	2019	Undifferentiated THP1 cells constitutively express NLRP3, and NLRP3 inflammasome activation occurred in response to canonical NLRP3 activation stimuli including nigericin, ATP, and urea crystals, culminating in pro-IL-1beta cleavage, extracellular release of mature IL-1beta, and pyroptosis.	Nigericin	161-170	GLI family zinc finger 2	Homo sapiens	17-21	
29145789-8	2018	Moreover, secreted IL-10 correlated with the down-regulation of nigericin-induced NLRP3 inflammasome activation of LPS-primed THP-1 monocytes and human PBMCs from volunteers.	Nigericin	64-73	GLI family zinc finger 2	Homo sapiens	126-131