PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31632394-7	2019	Macrophage response to nigericin was examined by RT gene profiling and subsequent qPCR, which demonstrated altered expression of a series of genes involved in the IL-18 bacterial killing pathway.	Nigericin	23-32	interleukin 18	Homo sapiens	163-168	
33613529-11	2020	Results: LPS/Nigericin increased NRLP3 protein expression as well as IL-1beta and IL-18 secretion in PC3 and U138MG cells compared to A549, MCF7, SH-SY5Y cells, and fibroblasts.	Nigericin	13-22	interleukin 18	Homo sapiens	82-87	
33101286-6	2020	NLRP3 activator nigericin caused the processing and release of constitutively expressed IL-18 in an unprimed setting.	Nigericin	16-25	interleukin 18	Homo sapiens	88-93	
33613529-18	2020	Discussion: Our data suggest that NLRP3 activation using Nigericin could be a novel therapeutic approach to control the growth of tumors producing a low level of IL-1beta and IL-18.	Nigericin	57-66	interleukin 18	Homo sapiens	175-180	
29479354-7	2018	To further understand the differential expression of cytokines/chemokines, we showed that WFA alters the nigericin-induced co-localization of NLRP3 and ASC proteins, thereby inhibiting caspase-1 activation, which is responsible for the cleavage and maturation of pro-inflammatory cytokines IL-1beta and IL-18.	Nigericin	105-114	interleukin 18	Homo sapiens	303-308	
30404814-7	2018	LPS or nigericin stimulation of PLAC8-overexpressing human monocytic cell line (THP-1), but not mock THP-1 cells, was associated with a significant decrease in IL-1beta and IL-18 production.	Nigericin	7-16	interleukin 18	Homo sapiens	173-178	
25770182-6	2015	CO also inhibited IL-18 secretion in response to LPS and nigericin treatment, another NLRP3 inflammasome activation model.	Nigericin	57-66	interleukin 18	Homo sapiens	18-23	
12934070-3	2003	We show that without LPS priming, nigericin alone triggered caspase-1 activation and IL-18 generation in THP-1 monocytic cells.	Nigericin	34-43	interleukin 18	Homo sapiens	85-90	
16441439-5	2006	We report that flagellin in pathophysiologically relevant concentrations augmented release of mature IL-18 by THP-1 monocytes, PBMC, and whole blood stimulated with nigericin or by ATP-mediated P2X7 purinergic receptor activation.	Nigericin	165-174	interleukin 18	Homo sapiens	101-106	
15306849-5	2004	Nigericin, a K(+) ionophore, induced a similar release of IL-18 from monocytes of either genotype.	Nigericin	0-9	interleukin 18	Homo sapiens	58-63	
12934070-8	2003	Collectively, our study establishes a critical role for cathepsin B in nigericin-induced caspase-1-dependent IL-18 maturation and caspase-1-independent necrosis.	Nigericin	71-80	interleukin 18	Homo sapiens	109-114