PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34457055-0 2021 Combination of nigericin with cisplatin enhances the inhibitory effect of cisplatin on epithelial ovarian cancer metastasis by inhibiting slug expression via the Wnt/beta-catenin signalling pathway. Nigericin 15-24 snail family transcriptional repressor 2 Homo sapiens 138-142 34457055-14 2021 When slug was knocked down, the effect of nigericin was weakened. Nigericin 42-51 snail family transcriptional repressor 2 Homo sapiens 5-9 34457055-15 2021 Overexpression of slug could repress the inhibitory effect of nigericin on the Wnt/beta-catenin signalling pathway. Nigericin 62-71 snail family transcriptional repressor 2 Homo sapiens 18-22 34457055-16 2021 Furthermore, nigericin inhibited slug expression by enhancing its modification through small ubiquitin-like modifiers (SUMOs; referred to as SUMOylation). Nigericin 13-22 snail family transcriptional repressor 2 Homo sapiens 33-37 34457055-18 2021 The underlying mechanism of combined therapy maybe the enhanced inhibitory effect of slug through its nigericin-induced SUMOylation. Nigericin 102-111 snail family transcriptional repressor 2 Homo sapiens 85-89