PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18539383-5 2008 Calu-6 cells treated with 1, 3 or 5 microM ATO showed a G2 phase arrest of the cell cycle at 72 h. The G2 phase arrest was accompanied with the down-regulation of cdc2 protein. Arsenic Trioxide 43-46 cyclin dependent kinase 1 Homo sapiens 163-167 19781537-10 2010 We also found that the combination of ATO and PTX at low concentrations synergistically induced mitotic arrest followed by apoptosis in malignant lymphocytes, which increased phosphorylated cyclin-dependent kinase 1 (Cdk1) on Thr(161) and promoted the dysregulated activation of Cdk1. Arsenic Trioxide 38-41 cyclin dependent kinase 1 Homo sapiens 190-215 19781537-10 2010 We also found that the combination of ATO and PTX at low concentrations synergistically induced mitotic arrest followed by apoptosis in malignant lymphocytes, which increased phosphorylated cyclin-dependent kinase 1 (Cdk1) on Thr(161) and promoted the dysregulated activation of Cdk1. Arsenic Trioxide 38-41 cyclin dependent kinase 1 Homo sapiens 217-221 19781537-10 2010 We also found that the combination of ATO and PTX at low concentrations synergistically induced mitotic arrest followed by apoptosis in malignant lymphocytes, which increased phosphorylated cyclin-dependent kinase 1 (Cdk1) on Thr(161) and promoted the dysregulated activation of Cdk1. Arsenic Trioxide 38-41 cyclin dependent kinase 1 Homo sapiens 279-283 22730174-5 2012 The sustained G2/M arrest by As(2)O(3) is associated with decreased cdc2 protein and increased phospho-cdc2(Tyr15). Arsenic Trioxide 29-38 cyclin dependent kinase 1 Homo sapiens 68-72 22730174-5 2012 The sustained G2/M arrest by As(2)O(3) is associated with decreased cdc2 protein and increased phospho-cdc2(Tyr15). Arsenic Trioxide 29-38 cyclin dependent kinase 1 Homo sapiens 103-107 18088464-6 2007 The p21, survivin, cdc2 and Wee1Hu genes may be related to the differentiation and/or apoptosis of NB4 cells induced by As2O3. Arsenic Trioxide 120-125 cyclin dependent kinase 1 Homo sapiens 19-23 18088464-7 2007 It is concluded that p21, survivin, cdc2 and Wee1Hu may play an important role in the mechanism underling arsenic trioxide-mediated NB4 cell apoptosis. Arsenic Trioxide 106-122 cyclin dependent kinase 1 Homo sapiens 36-40 10558879-9 1999 Furthermore, treatment of As(2)O(3) markedly enhanced the binding of p21 with cdc2, and the activity of cdc2 kinase was decreased in a time-dependent manner. Arsenic Trioxide 26-35 cyclin dependent kinase 1 Homo sapiens 78-82 16517539-4 2006 With arsenic trioxide exposure, both cell lines were arrested at the S-G2/M phase with the increase of cyclin B expression and CDK1 activity. Arsenic Trioxide 5-21 cyclin dependent kinase 1 Homo sapiens 127-131 10850458-5 2000 Western blot analysis demonstrated that treatment with As2O3 (2 microM) for 72 h did not change the steady-state levels of CDK2, CDK4, cyclin D1, cyclin E, and cyclin B1 but decreased the levels of CDK6, cdc2, and cyclin A. Arsenic Trioxide 55-60 cyclin dependent kinase 1 Homo sapiens 204-208 10850458-7 2000 In addition, As2O3 markedly enhanced the binding of p21 with CDK6, cdc2, cyclin E, and cyclin A compared with untreated control cells. Arsenic Trioxide 13-18 cyclin dependent kinase 1 Homo sapiens 67-71 10558879-9 1999 Furthermore, treatment of As(2)O(3) markedly enhanced the binding of p21 with cdc2, and the activity of cdc2 kinase was decreased in a time-dependent manner. Arsenic Trioxide 26-35 cyclin dependent kinase 1 Homo sapiens 104-108