PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18539383-5	2008	Calu-6 cells treated with 1, 3 or 5 microM ATO showed a G2 phase arrest of the cell cycle at 72 h. The G2 phase arrest was accompanied with the down-regulation of cdc2 protein.	Arsenic Trioxide	43-46	cyclin dependent kinase 1	Homo sapiens	163-167	
19781537-10	2010	We also found that the combination of ATO and PTX at low concentrations synergistically induced mitotic arrest followed by apoptosis in malignant lymphocytes, which increased phosphorylated cyclin-dependent kinase 1 (Cdk1) on Thr(161) and promoted the dysregulated activation of Cdk1.	Arsenic Trioxide	38-41	cyclin dependent kinase 1	Homo sapiens	190-215	
19781537-10	2010	We also found that the combination of ATO and PTX at low concentrations synergistically induced mitotic arrest followed by apoptosis in malignant lymphocytes, which increased phosphorylated cyclin-dependent kinase 1 (Cdk1) on Thr(161) and promoted the dysregulated activation of Cdk1.	Arsenic Trioxide	38-41	cyclin dependent kinase 1	Homo sapiens	217-221	
19781537-10	2010	We also found that the combination of ATO and PTX at low concentrations synergistically induced mitotic arrest followed by apoptosis in malignant lymphocytes, which increased phosphorylated cyclin-dependent kinase 1 (Cdk1) on Thr(161) and promoted the dysregulated activation of Cdk1.	Arsenic Trioxide	38-41	cyclin dependent kinase 1	Homo sapiens	279-283	
22730174-5	2012	The sustained G2/M arrest by As(2)O(3) is associated with decreased cdc2 protein and increased phospho-cdc2(Tyr15).	Arsenic Trioxide	29-38	cyclin dependent kinase 1	Homo sapiens	68-72	
22730174-5	2012	The sustained G2/M arrest by As(2)O(3) is associated with decreased cdc2 protein and increased phospho-cdc2(Tyr15).	Arsenic Trioxide	29-38	cyclin dependent kinase 1	Homo sapiens	103-107	
18088464-6	2007	The p21, survivin, cdc2 and Wee1Hu genes may be related to the differentiation and/or apoptosis of NB4 cells induced by As2O3.	Arsenic Trioxide	120-125	cyclin dependent kinase 1	Homo sapiens	19-23	
18088464-7	2007	It is concluded that p21, survivin, cdc2 and Wee1Hu may play an important role in the mechanism underling arsenic trioxide-mediated NB4 cell apoptosis.	Arsenic Trioxide	106-122	cyclin dependent kinase 1	Homo sapiens	36-40	
10558879-9	1999	Furthermore, treatment of As(2)O(3) markedly enhanced the binding of p21 with cdc2, and the activity of cdc2 kinase was decreased in a time-dependent manner.	Arsenic Trioxide	26-35	cyclin dependent kinase 1	Homo sapiens	78-82	
16517539-4	2006	With arsenic trioxide exposure, both cell lines were arrested at the S-G2/M phase with the increase of cyclin B expression and CDK1 activity.	Arsenic Trioxide	5-21	cyclin dependent kinase 1	Homo sapiens	127-131	
10850458-5	2000	Western blot analysis demonstrated that treatment with As2O3 (2 microM) for 72 h did not change the steady-state levels of CDK2, CDK4, cyclin D1, cyclin E, and cyclin B1 but decreased the levels of CDK6, cdc2, and cyclin A.	Arsenic Trioxide	55-60	cyclin dependent kinase 1	Homo sapiens	204-208	
10850458-7	2000	In addition, As2O3 markedly enhanced the binding of p21 with CDK6, cdc2, cyclin E, and cyclin A compared with untreated control cells.	Arsenic Trioxide	13-18	cyclin dependent kinase 1	Homo sapiens	67-71	
10558879-9	1999	Furthermore, treatment of As(2)O(3) markedly enhanced the binding of p21 with cdc2, and the activity of cdc2 kinase was decreased in a time-dependent manner.	Arsenic Trioxide	26-35	cyclin dependent kinase 1	Homo sapiens	104-108