PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25845556-6 2015 As4O6 suppressed NF-kappaB activation and suppressed inhibitory kappaBalpha (IkappaBalpha) phosphorylation stimulated by tumor necrosis factor (TNF). Arsenic Trioxide 0-5 tumor necrosis factor Homo sapiens 121-142 25845556-6 2015 As4O6 suppressed NF-kappaB activation and suppressed inhibitory kappaBalpha (IkappaBalpha) phosphorylation stimulated by tumor necrosis factor (TNF). Arsenic Trioxide 0-5 tumor necrosis factor Homo sapiens 144-147 24627159-6 2014 As4O6 suppressed NF-kappaB activation in both TNF-alpha-treated and control cells, and also suppressed IkappaB phosphorylation in a time-dependent manner, suggesting the suppression of NF-kappaB results, in part, from the inhibition of IkappaB degradation. Arsenic Trioxide 0-5 tumor necrosis factor Homo sapiens 46-55 24627159-7 2014 We also confirmed the anti-NF-kappaB activity of As4O6 with synergism with TNF-alpha by augmenting caspase-8 activation. Arsenic Trioxide 49-54 tumor necrosis factor Homo sapiens 75-84 24627159-8 2014 As4O6 also suppressed NF-kappaB activation induced by TNF-alpha, and some of the downstream NF-kappaB-regulated proteins involved in cancer proliferation, anti-apoptosis and metastasis. Arsenic Trioxide 0-5 tumor necrosis factor Homo sapiens 54-63 24627159-9 2014 In conclusion, the present study demonstrated that As4O6 has anticancer properties by inhibiting NF-kappaB activation and NF-kappaB-regulated proteins at least in part through the inhibition of IkappaB phosphorylation, especially in the conditions of advanced cancer where TNF-alpha is highly secreted. Arsenic Trioxide 51-56 tumor necrosis factor Homo sapiens 273-282 22384180-10 2012 Furthermore, we observed the effect of As(2)O(3) on TNF-alpha-induced NF-kappaB signaling pathway was to significantly reduced phosphorylation of Ser-536 on NF-kappaB p65. Arsenic Trioxide 39-48 tumor necrosis factor Homo sapiens 52-61 21078271-9 2010 Also compound of AKBA and ATO inhibited secretions of TNF-alpha and IL-1beta in THP-1 cells and cell coculture system (P<0.01). Arsenic Trioxide 26-29 tumor necrosis factor Homo sapiens 54-63 22966360-0 2010 Effect of thalidomide and arsenic trioxide on the release of tumor necrosis factor-alpha and vascular endothelial growth factor from the KG-1a human acute myelogenous leukemia cell line. Arsenic Trioxide 26-42 tumor necrosis factor Homo sapiens 61-88 22966360-2 2010 The current investigation was conducted in order to evaluate the effect of thalidomide either alone or in combination with arsenic trioxide on the release of tumor necrosis factor-alpha (TNF-alpha) and vascular endothelial growth factor (VEGF) from this cell line in an attempt to clarify its possible cytotoxic mechanism(s). Arsenic Trioxide 123-139 tumor necrosis factor Homo sapiens 158-185 22966360-2 2010 The current investigation was conducted in order to evaluate the effect of thalidomide either alone or in combination with arsenic trioxide on the release of tumor necrosis factor-alpha (TNF-alpha) and vascular endothelial growth factor (VEGF) from this cell line in an attempt to clarify its possible cytotoxic mechanism(s). Arsenic Trioxide 123-139 tumor necrosis factor Homo sapiens 187-196 22966360-6 2010 Results obtained indicate that the levels of TNF-alpha in the supernatant of KG-1a cell cultures incubated with thalidomide, arsenic trioxide, or combination were statistically lower than those observed in the supernatant of control cells (2.89, 5.07, 4.15 and 16.88 pg/ml, respectively). Arsenic Trioxide 125-141 tumor necrosis factor Homo sapiens 45-54 22966360-9 2010 These findings indicate that thalidomide and the arsenic trioxide inhibition of TNF-alpha production by KG-1a cells may play an important role in their cytotoxic effect. Arsenic Trioxide 49-65 tumor necrosis factor Homo sapiens 80-89 29088724-8 2017 We show that As2O3 inhibits angiogenesis in the collagen-induced arthritis (CIA) synovium and consequently arthritis severity via significant suppression of TSP-1, TGF-beta1, CTGF and VEGF expression in the CIA synovium, plus in the RA-FLS and HDMECs co-culture as well as NH-FLS and HDMECs co-culture system along with the presence or absence of TNF-alpha treatment. Arsenic Trioxide 13-18 tumor necrosis factor Homo sapiens 347-356 12148893-7 2002 In conclusion, As2O3 induces apoptosis in HTLV-I infected T-cell lines and fresh ATL cells through CD95 or TNF-alpha receptor independent caspase activation. Arsenic Trioxide 15-20 tumor necrosis factor Homo sapiens 107-116 32168763-6 2020 The irreversible inhibitor of TG2 NC9 not only decreased reactive oxygen species production 28-fold, but decreased the concentration of MCP-1, IL-1beta and TNF-alpha 8-, 15- and 61-fold, respectively in the combined ATRA + ATO-treated wild-type NB4 cell culture. Arsenic Trioxide 223-226 tumor necrosis factor Homo sapiens 156-165 17673311-0 2007 Arsenic trioxide sensitizes promonocytic leukemia cells to TNFalpha-induced apoptosis via p38-MAPK-regulated activation of both receptor-mediated and mitochondrial pathways. Arsenic Trioxide 0-16 tumor necrosis factor Homo sapiens 59-67 17673311-1 2007 Treatment with the anti-leukemic drug arsenic trioxide (As(2)O(3), 1-4 microM) sensitizes U937 promonocytes and other human myeloid leukemia cell lines (HL60, NB4) to apoptosis induction by TNFalpha. Arsenic Trioxide 38-54 tumor necrosis factor Homo sapiens 190-198 16920938-6 2006 In addition, As2O3 reduced expression of various macrophagic surface markers, enhanced that of the monocytic marker CD14, and altered both endocytosis and phagocytosis; unexpectedly, exposure of macrophages to the metalloid also strongly potentiated expression of TNFalpha and IL-8 induced by LPS. Arsenic Trioxide 13-18 tumor necrosis factor Homo sapiens 264-272 28404891-3 2017 HMGB1 and the pro-inflammatory cytokines IL-1beta and TNF-alpha were gradually released from NB4 and HL-60 cells treated with ATRA and/or ATO. Arsenic Trioxide 138-141 tumor necrosis factor Homo sapiens 54-63 26276563-11 2016 The results showed that the expression levels of IL-6, IL-8, TNF-alpha, and NF-kappaB which seemed to be a critical mediator in the inflammatory response tended to increase in the birds chronically treated with As2O3. Arsenic Trioxide 211-216 tumor necrosis factor Homo sapiens 61-70