PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16540180-3	2006	Arsenic trioxide (As(2)O(3)) has been shown to synergize with IFN-alpha in arresting cell growth and inducing apoptosis of ATLL cells in vitro.	Arsenic Trioxide	0-16	interferon alpha 1	Homo sapiens	62-71	
17568816-4	2007	We previously reported that treatment of human T-cell leukemia virus type 1 (HTLV-1)-associated adult T-cell leukemia/lymphoma cells either with arsenic trioxide (As) combined to interferon-alpha (IFN-alpha) or with the bortezomib (PS-341) proteasome inhibitor induces cell cycle arrest and apoptosis, partly due to the reversal of the constitutive nuclear factor-kappaB (NF-kappaB) activation.	Arsenic Trioxide	163-165	interferon alpha 1	Homo sapiens	197-206	
21106154-1	2001	BACKGROUND: To study apoptosis of small cell lung cancer (SCLC) cell induced by As2O3 and enhancement effect of interferon (IFN) on As2O3.	Arsenic Trioxide	132-137	interferon alpha 1	Homo sapiens	112-128	
15354410-5	2004	Recent studies have proven this true, with all-trans retinoic acid, IFN-alpha, and ascorbic acid all yielding promising results when used in conjunction with arsenic trioxide.	Arsenic Trioxide	158-174	interferon alpha 1	Homo sapiens	68-77	
21106154-5	2001	The apoptosis inducing effect of As2O3 combined with IFN was much higher than that of As2O3 alone.	Arsenic Trioxide	86-91	interferon alpha 1	Homo sapiens	53-56	
11783079-1	2001	OBJECTIVE: To investigate the possible mechanisms of arsenic trioxide (As2O3)-induced apoptosis in multiple myeloma (MM) cell line, and the interactions between As2O3 and all-trans retinoic acid (ATRA) or interferon(IFN)-alpha.	Arsenic Trioxide	53-69	interferon alpha 1	Homo sapiens	205-226	
11783079-2	2001	METHODS: Multiple myeloma cell lines RPMI 8226 and U266 were treated with As2O3 in combination with dithiothreitol (DTT), buthionine sulfoximine (BSO), ATRA and IFN-alpha.	Arsenic Trioxide	74-79	interferon alpha 1	Homo sapiens	161-170	
33075130-3	2021	ATO sharply potentiated IFNalpha-induced growth suppression of JAK2V617F patient or mouse hematopoietic progenitors, which required PML and was associated with features of senescence.	Arsenic Trioxide	0-3	interferon alpha 1	Homo sapiens	24-32	
32642412-4	2020	Notably, at clinical relevant concentrations, As2O3 preferentially inhibited IFN-alpha secretion as compared to other cytokines such as TNF-alpha, probably due to potent down-regulation of the total protein and mRNA expression, as well as phosphorylation of the interferon regulatory factor 7 (IRF7).	Arsenic Trioxide	46-51	interferon alpha 1	Homo sapiens	77-86