PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34255251-7 2021 Real-time RT-PCR indicated that the co-administration of Schiff base oxovanadium complex 40 microg/ml and arsenic trioxide 0.001 microM could increase the expression of P53 and P21 genes by 3.76 +- 0.19 and 6.57 +- 1.29 fold change, respectively to the control sample. Arsenic Trioxide 106-122 H3 histone pseudogene 16 Homo sapiens 177-180 34730462-0 2021 Polymorphisms of the AS3MT gene are associated with arsenic methylation capacity and damage to the P21 gene in arsenic trioxide plant workers. Arsenic Trioxide 111-127 H3 histone pseudogene 16 Homo sapiens 99-102 34730462-7 2021 In our study, we investigate whether polymorphisms of the AS3MT gene alter As methylation capacity and adversely affect the P21 gene in arsenic trioxide plant workers. Arsenic Trioxide 136-152 H3 histone pseudogene 16 Homo sapiens 124-127 20458559-0 2011 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Arsenic Trioxide 109-125 H3 histone pseudogene 16 Homo sapiens 46-49 23645216-0 2013 Azidothymidine hinders arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells by induction of p21 and attenuation of G2/M arrest. Arsenic Trioxide 23-39 H3 histone pseudogene 16 Homo sapiens 112-115 23645216-6 2013 QRT-PCR assay revealed that induction of p21expression by the combined AZT/ATO compared to ATO alone could be a reason for the relative decline of cells accumulation in G2/M and the increase of cells in G1 and S phases. Arsenic Trioxide 75-78 H3 histone pseudogene 16 Homo sapiens 41-44 23645216-6 2013 QRT-PCR assay revealed that induction of p21expression by the combined AZT/ATO compared to ATO alone could be a reason for the relative decline of cells accumulation in G2/M and the increase of cells in G1 and S phases. Arsenic Trioxide 91-94 H3 histone pseudogene 16 Homo sapiens 41-44 26117010-8 2015 Also, the expression of BCL-2 and survivin significantly decreased, while the expression of BAX, P21 and P27 was significantly upregulated in HL-60 cells after being treated with 5.0 micromol/L As2O3. Arsenic Trioxide 194-199 H3 histone pseudogene 16 Homo sapiens 97-100 20458559-6 2011 Notably, As2O3 treatment increased the mRNA and protein levels of the cell cycle inhibitory proteins, p21 and p27. Arsenic Trioxide 9-14 H3 histone pseudogene 16 Homo sapiens 102-105 20458559-7 2011 Interestingly, knocking down p21 or p27 individually did not alter As2O3-induced apoptosis and cell cycle arrest; however, the simultaneous down-regulation of both p21 and p27 resulted in attenuating of G1, G2/M arrest and reduction in apoptosis, thus indicating that p21 and p27 as the primary molecular targets of As2O3 against breast cancer. Arsenic Trioxide 316-321 H3 histone pseudogene 16 Homo sapiens 164-167 20458559-7 2011 Interestingly, knocking down p21 or p27 individually did not alter As2O3-induced apoptosis and cell cycle arrest; however, the simultaneous down-regulation of both p21 and p27 resulted in attenuating of G1, G2/M arrest and reduction in apoptosis, thus indicating that p21 and p27 as the primary molecular targets of As2O3 against breast cancer. Arsenic Trioxide 316-321 H3 histone pseudogene 16 Homo sapiens 164-167 21257625-5 2011 In this study, we found that 1 muM ATO promoted MSC senescence mainly through p21, although it had no effect on apoptosis at this dose. Arsenic Trioxide 35-38 H3 histone pseudogene 16 Homo sapiens 78-81 19951532-13 2009 The expression level of P21 was up-regulated after the NB4 cells treated with As2O3. Arsenic Trioxide 78-83 H3 histone pseudogene 16 Homo sapiens 24-27 19951532-16 2009 P21 is up-regulated after arsenic trioxide activated the JAK1 to inhibit the proliferation of NB4 cells. Arsenic Trioxide 26-42 H3 histone pseudogene 16 Homo sapiens 0-3 17390014-8 2007 However, the apoptosis-related proteins such as p21 and Bax were overexpressed by As4O6. Arsenic Trioxide 82-87 H3 histone pseudogene 16 Homo sapiens 48-51 17404572-8 2007 The inability of overexpressed p18 Bax to locate to the nucleus, and the As(2)O(3)-induced reduction of p21 Bax in the cytosol, suggest an As(2)O(3)-induced mechanism where p18 Bax gets cleaved and "trapped" in the nucleus. Arsenic Trioxide 73-82 H3 histone pseudogene 16 Homo sapiens 104-107 18088464-6 2007 The p21, survivin, cdc2 and Wee1Hu genes may be related to the differentiation and/or apoptosis of NB4 cells induced by As2O3. Arsenic Trioxide 120-125 H3 histone pseudogene 16 Homo sapiens 4-7 18088464-7 2007 It is concluded that p21, survivin, cdc2 and Wee1Hu may play an important role in the mechanism underling arsenic trioxide-mediated NB4 cell apoptosis. Arsenic Trioxide 106-122 H3 histone pseudogene 16 Homo sapiens 21-24 10850458-0 2000 Arsenic trioxide-mediated growth inhibition in MC/CAR myeloma cells via cell cycle arrest in association with induction of cyclin-dependent kinase inhibitor, p21, and apoptosis. Arsenic Trioxide 0-16 H3 histone pseudogene 16 Homo sapiens 158-161 10850458-6 2000 The mRNA and protein levels of CDKI, p21 were increased by treatment with As2O3, but those of p27 were not. Arsenic Trioxide 74-79 H3 histone pseudogene 16 Homo sapiens 37-40 10850458-7 2000 In addition, As2O3 markedly enhanced the binding of p21 with CDK6, cdc2, cyclin E, and cyclin A compared with untreated control cells. Arsenic Trioxide 13-18 H3 histone pseudogene 16 Homo sapiens 52-55 10850458-12 2000 These results suggest that As2O3 inhibits the proliferation of myeloma cells, especially MC/CAR cells, via cell cycle arrest in association with induction of p21 and apoptosis. Arsenic Trioxide 27-32 H3 histone pseudogene 16 Homo sapiens 158-161