PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29371980-5 2017 However, the GLI inhibitor arsenic trioxide reduced the expression of GLI target genes in the PhKh1 cells and in combination with radiotherapy significantly decreased their clonogenic potential. Arsenic Trioxide 27-43 GLI family zinc finger 1 Homo sapiens 13-16 32953511-12 2020 As2O3 dramatically downregulated GLI1 and its downstream genes in vitro and in vivo. Arsenic Trioxide 0-5 GLI family zinc finger 1 Homo sapiens 33-37 32953511-13 2020 The GLI inhibitor (GANT-61) recapitulated and enhanced the effects of As2O3 on SCLC-derived CSCs, including growth suppression, apoptosis induction, and GLI1, SOX2 and c-Myc downregulation. Arsenic Trioxide 70-75 GLI family zinc finger 1 Homo sapiens 4-7 30649745-8 2019 The other approved compound is arsenic trioxide, which can suppress this pathway at the level of the GLI proteins, although current evidence suggests it also has other targets. Arsenic Trioxide 31-47 GLI family zinc finger 1 Homo sapiens 101-104 29371980-5 2017 However, the GLI inhibitor arsenic trioxide reduced the expression of GLI target genes in the PhKh1 cells and in combination with radiotherapy significantly decreased their clonogenic potential. Arsenic Trioxide 27-43 GLI family zinc finger 1 Homo sapiens 70-73 27793025-10 2016 Treatment with GLI1/2 inhibitors, including arsenic trioxide, significantly increased GLI3 binding to the KIT promoter, decreased KIT expression, and reduced viability in imatinib-sensitive and imatinib-resistant GIST cells. Arsenic Trioxide 44-60 GLI family zinc finger 1 Homo sapiens 15-21 26765315-3 2016 OBJECTIVE: To determine whether administration of intravenous arsenic trioxide and oral itraconazole in patients with metastatic BCC is associated with a reduction in GLI1 messenger RNA expression in tumor and/or normal skin biopsy samples. Arsenic Trioxide 62-78 GLI family zinc finger 1 Homo sapiens 167-171 27158399-0 2016 Arsenic trioxide inhibits cancer stem-like cells via down-regulation of Gli1 in lung cancer. Arsenic Trioxide 0-16 GLI family zinc finger 1 Homo sapiens 72-76 27158399-2 2016 Activated Hedgehog signaling pathway has been proved to be implicated in the maintenance of self-renewal of CSCs, and arsenic trioxide (As2O3) has been reported to inhibit Gli1, a key transcription factor of Hedgehog pathway. Arsenic Trioxide 118-134 GLI family zinc finger 1 Homo sapiens 172-176 27158399-2 2016 Activated Hedgehog signaling pathway has been proved to be implicated in the maintenance of self-renewal of CSCs, and arsenic trioxide (As2O3) has been reported to inhibit Gli1, a key transcription factor of Hedgehog pathway. Arsenic Trioxide 136-141 GLI family zinc finger 1 Homo sapiens 172-176 27158399-7 2016 Moreover, the effects of As2O3 on expression of Gli1 and its target genes were observed. Arsenic Trioxide 25-30 GLI family zinc finger 1 Homo sapiens 48-52 27158399-11 2016 Furthermore, As2O3 decreased the expression of Gli1, N-myc and GAS1. Arsenic Trioxide 13-18 GLI family zinc finger 1 Homo sapiens 47-51 26765315-11 2016 Overall, arsenic trioxide and itraconazole reduced GLI1 messenger RNA levels by 75% from baseline (P < .001). Arsenic Trioxide 9-25 GLI family zinc finger 1 Homo sapiens 51-55 21183792-0 2011 Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway. Arsenic Trioxide 0-16 GLI family zinc finger 1 Homo sapiens 102-105 24420698-0 2014 Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1. Arsenic Trioxide 0-16 GLI family zinc finger 1 Homo sapiens 121-125 23990729-0 2013 Arsenic trioxide inhibits viability of pancreatic cancer stem cells in culture and in a xenograft model via binding to SHH-Gli. Arsenic Trioxide 0-16 GLI family zinc finger 1 Homo sapiens 123-126 25577250-3 2015 Arsenic trioxide (ATO) has been demonstrated to suppress human cancer cell growth by targeting Gli1. Arsenic Trioxide 0-16 GLI family zinc finger 1 Homo sapiens 95-99 25577250-3 2015 Arsenic trioxide (ATO) has been demonstrated to suppress human cancer cell growth by targeting Gli1. Arsenic Trioxide 18-21 GLI family zinc finger 1 Homo sapiens 95-99 25945059-0 2015 Synergistic inhibition of colon carcinoma cell growth by Hedgehog-Gli1 inhibitor arsenic trioxide and phosphoinositide 3-kinase inhibitor LY294002. Arsenic Trioxide 81-97 GLI family zinc finger 1 Homo sapiens 66-70 25945059-3 2015 Here, we sought to investigate the regulation of the Hh pathway transcription factor Gli1 by arsenic trioxide and phosphoinositide 3-kinase (PI3K) inhibitor LY294002 in colon carcinoma cells. Arsenic Trioxide 93-109 GLI family zinc finger 1 Homo sapiens 85-89 25945059-7 2015 To elucidate the regulation of Gli1 expression, we found that both Gli inhibitor arsenic trioxide and PI3K inhibitor LY294002 significantly reduced Gli1 protein expression and colon carcinoma cell proliferation. Arsenic Trioxide 81-97 GLI family zinc finger 1 Homo sapiens 31-35 25945059-7 2015 To elucidate the regulation of Gli1 expression, we found that both Gli inhibitor arsenic trioxide and PI3K inhibitor LY294002 significantly reduced Gli1 protein expression and colon carcinoma cell proliferation. Arsenic Trioxide 81-97 GLI family zinc finger 1 Homo sapiens 31-34 25945059-7 2015 To elucidate the regulation of Gli1 expression, we found that both Gli inhibitor arsenic trioxide and PI3K inhibitor LY294002 significantly reduced Gli1 protein expression and colon carcinoma cell proliferation. Arsenic Trioxide 81-97 GLI family zinc finger 1 Homo sapiens 148-152 25945059-8 2015 Arsenic trioxide treatment also reduced Gli1 downstream target gene expression, such as Bcl2 and CCND1. Arsenic Trioxide 0-16 GLI family zinc finger 1 Homo sapiens 40-44 25945059-9 2015 More importantly, the inhibition of Hedgehog-Gli1 by arsenic trioxide showed synergistic anticancer effect with the PI3K inhibitor LY294002 in colon carcinoma cells. Arsenic Trioxide 53-69 GLI family zinc finger 1 Homo sapiens 45-49 25945059-11 2015 Inhibition of Hedgehog-Gli1 expression by arsenic trioxide and PI3K inhibitor synergistically reduces colon cancer cell proliferation, indicating that they could be used as an effective anti-colon cancer combination therapy. Arsenic Trioxide 42-58 GLI family zinc finger 1 Homo sapiens 23-27 23861973-0 2013 Arsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulation. Arsenic Trioxide 0-16 GLI family zinc finger 1 Homo sapiens 63-66 23861973-3 2013 Recently, it has been reported that arsenic trioxide (ATO) inhibits cancer growth by blocking GLI transcription. Arsenic Trioxide 36-52 GLI family zinc finger 1 Homo sapiens 94-97 23861973-3 2013 Recently, it has been reported that arsenic trioxide (ATO) inhibits cancer growth by blocking GLI transcription. Arsenic Trioxide 54-57 GLI family zinc finger 1 Homo sapiens 94-97 23867347-3 2013 Implications that Gli proteins are molecular targets of arsenic trioxide (ATO) action prompted us to investigate the expression of Hh signaling in acute promyelocytic leukemia (APL) and the influence of ATO on the Hh signaling pathway in APL. Arsenic Trioxide 56-72 GLI family zinc finger 1 Homo sapiens 18-21 23867347-3 2013 Implications that Gli proteins are molecular targets of arsenic trioxide (ATO) action prompted us to investigate the expression of Hh signaling in acute promyelocytic leukemia (APL) and the influence of ATO on the Hh signaling pathway in APL. Arsenic Trioxide 74-77 GLI family zinc finger 1 Homo sapiens 18-21 21183792-6 2011 Consistent with this, ATO inhibited the growth of human cancer cell lines that depended on upregulated GLI expression in vitro and in vivo in a xenograft model of Ewing sarcoma. Arsenic Trioxide 22-25 GLI family zinc finger 1 Homo sapiens 103-106 21183792-8 2011 Our results establish ATO as a Hh pathway inhibitor acting at the level of GLI1 both in vitro and in vivo. Arsenic Trioxide 22-25 GLI family zinc finger 1 Homo sapiens 75-79