PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27794399-13	2016	MG-132 partially reversed the degradation of Akt, Src, c-Raf and Erk induced by ATO/PD, suggestive of ubiquitin-independent proteasome-dependent degradation.	Arsenic Trioxide	80-83	thymoma viral proto-oncogene 1	Mus musculus	45-48	
27794399-16	2016	CONCLUSION: Massive protein degradation (FGFR1, Akt, Src, c-Raf and Erk) was induced by ATO and/or PD173074 treatment mainly mediated by activation of proteasomal degradation in SCC cell line SK-MES-1 in vitro and in vivo.	Arsenic Trioxide	88-91	thymoma viral proto-oncogene 1	Mus musculus	48-51	
20299303-7	2010	As2O3 significantly and dose-dependently decreased phosphorylation of Akt and p70s6k proteins during myogenic differentiation.	Arsenic Trioxide	0-5	thymoma viral proto-oncogene 1	Mus musculus	70-73	
20299303-8	2010	As2O3-induced inhibition in myotube formation and muscle-specific protein expression was reversed by transfection with the constitutively active form of Akt.	Arsenic Trioxide	0-5	thymoma viral proto-oncogene 1	Mus musculus	153-156	
20299303-10	2010	Regeneration of glycerol-injured soleus muscles, myogenin expression, and Akt phosphorylation were suppressed in muscles isolated from As2O3-treated mice compared with untreated mice.	Arsenic Trioxide	135-140	thymoma viral proto-oncogene 1	Mus musculus	74-77	
20299303-11	2010	CONCLUSION: Our results suggest that As2O3 inhibits myogenic differentiation by inhibiting Akt-regulated signaling.	Arsenic Trioxide	37-42	thymoma viral proto-oncogene 1	Mus musculus	91-94	
15916724-6	2005	We found that arsenic trioxide induced the expression and the phosphorylation of Akt/PKB and it inhibited the interaction between Akt/PKB and PPARgamma .	Arsenic Trioxide	14-30	thymoma viral proto-oncogene 1	Mus musculus	81-84	
15916724-0	2005	The role of Akt on arsenic trioxide suppression of 3T3-L1 preadipocyte differentiation.	Arsenic Trioxide	19-35	thymoma viral proto-oncogene 1	Mus musculus	12-15	
15916724-6	2005	We found that arsenic trioxide induced the expression and the phosphorylation of Akt/PKB and it inhibited the interaction between Akt/PKB and PPARgamma .	Arsenic Trioxide	14-30	thymoma viral proto-oncogene 1	Mus musculus	85-88	
15916724-6	2005	We found that arsenic trioxide induced the expression and the phosphorylation of Akt/PKB and it inhibited the interaction between Akt/PKB and PPARgamma .	Arsenic Trioxide	14-30	thymoma viral proto-oncogene 1	Mus musculus	81-88	
15916724-7	2005	Akt/PKB inhibitor appears to block the arsenic trioxide suppression of differentiation.	Arsenic Trioxide	39-55	thymoma viral proto-oncogene 1	Mus musculus	0-7	
33462182-0	2021	Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway.	Arsenic Trioxide	0-16	thymoma viral proto-oncogene 1	Mus musculus	126-129	
33462182-9	2021	Moreover, ATO decreased the p-AKT and p-mTOR in the PI3K/AKT/mTOR signaling pathway, thus inducing autophagy.	Arsenic Trioxide	10-13	thymoma viral proto-oncogene 1	Mus musculus	30-33	
33462182-9	2021	Moreover, ATO decreased the p-AKT and p-mTOR in the PI3K/AKT/mTOR signaling pathway, thus inducing autophagy.	Arsenic Trioxide	10-13	thymoma viral proto-oncogene 1	Mus musculus	57-60	
33462182-15	2021	In summary, our data indicated that ATO promoted ROS induction, which resulted in nuclear translocation of TFEB and inhibition of the PI3K/AKT/mTOR pathway.	Arsenic Trioxide	36-39	thymoma viral proto-oncogene 1	Mus musculus	139-142