PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26966376-0	2016	Arsenic trioxide inhibits viability and induces apoptosis through reactivating the Wnt inhibitor secreted frizzled related protein-1 in prostate cancer cells.	Arsenic Trioxide	0-16	secreted frizzled related protein 1	Homo sapiens	97-132	
26966376-8	2016	In addition, As2O3 upregulated the protein and mRNA levels of secreted frizzled related protein-1, and increased the demethylation of the SFRP1 gene promoter.	Arsenic Trioxide	13-18	secreted frizzled related protein 1	Homo sapiens	62-97	
26966376-8	2016	In addition, As2O3 upregulated the protein and mRNA levels of secreted frizzled related protein-1, and increased the demethylation of the SFRP1 gene promoter.	Arsenic Trioxide	13-18	secreted frizzled related protein 1	Homo sapiens	138-143	
26966376-9	2016	CONCLUSION: Our results suggest that As2O3 may inhibit cell viability and induce apoptosis through reactivating the Wnt inhibitor secreted frizzled related protein-1 in both androgen-dependent and -independent human PCa.	Arsenic Trioxide	37-42	secreted frizzled related protein 1	Homo sapiens	130-165	
23611225-0	2013	[Abnormal methylation patterns of SFRP1 gene in cells of leukemia and inhibition of arsenic trioxide on the SFRP1 gene].	Arsenic Trioxide	84-100	secreted frizzled related protein 1	Homo sapiens	34-39	
23611225-0	2013	[Abnormal methylation patterns of SFRP1 gene in cells of leukemia and inhibition of arsenic trioxide on the SFRP1 gene].	Arsenic Trioxide	84-100	secreted frizzled related protein 1	Homo sapiens	108-113	
28565807-0	2017	Arsenic trioxide increases expression of secreted frizzled-related protein 1 gene and inhibits the WNT/beta-catenin signaling pathway in Jurkat cells.	Arsenic Trioxide	0-16	secreted frizzled related protein 1	Homo sapiens	41-76	
28565807-1	2017	The aim of the present study was to investigate the demethylation effect of arsenic trioxide (As2O3) on the secreted frizzled-related protein 1 (SFRP1) gene and its ability to inhibit the Wingless-type MMTV integration site family (WNT) pathway in Jurkat cells.	Arsenic Trioxide	76-92	secreted frizzled related protein 1	Homo sapiens	108-143	
28565807-1	2017	The aim of the present study was to investigate the demethylation effect of arsenic trioxide (As2O3) on the secreted frizzled-related protein 1 (SFRP1) gene and its ability to inhibit the Wingless-type MMTV integration site family (WNT) pathway in Jurkat cells.	Arsenic Trioxide	76-92	secreted frizzled related protein 1	Homo sapiens	145-150	
28565807-1	2017	The aim of the present study was to investigate the demethylation effect of arsenic trioxide (As2O3) on the secreted frizzled-related protein 1 (SFRP1) gene and its ability to inhibit the Wingless-type MMTV integration site family (WNT) pathway in Jurkat cells.	Arsenic Trioxide	94-99	secreted frizzled related protein 1	Homo sapiens	108-143	
28565807-1	2017	The aim of the present study was to investigate the demethylation effect of arsenic trioxide (As2O3) on the secreted frizzled-related protein 1 (SFRP1) gene and its ability to inhibit the Wingless-type MMTV integration site family (WNT) pathway in Jurkat cells.	Arsenic Trioxide	94-99	secreted frizzled related protein 1	Homo sapiens	145-150	
28565807-8	2017	Following treatment with As2O3 for 48 h, the SFRP1 gene was demethylated, and the mRNA and protein expression levels of the SFRP1 gene were increased.	Arsenic Trioxide	25-30	secreted frizzled related protein 1	Homo sapiens	45-50	
28565807-8	2017	Following treatment with As2O3 for 48 h, the SFRP1 gene was demethylated, and the mRNA and protein expression levels of the SFRP1 gene were increased.	Arsenic Trioxide	25-30	secreted frizzled related protein 1	Homo sapiens	124-129	
28565807-12	2017	These results suggest that As2O3 activates SFRP1 gene expression at the mRNA and protein levels in Jurkat cells by demethylation of the SFRP1 gene.	Arsenic Trioxide	27-32	secreted frizzled related protein 1	Homo sapiens	43-48	
28565807-12	2017	These results suggest that As2O3 activates SFRP1 gene expression at the mRNA and protein levels in Jurkat cells by demethylation of the SFRP1 gene.	Arsenic Trioxide	27-32	secreted frizzled related protein 1	Homo sapiens	136-141