PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21777978-4	2011	In the present study, we determined molecular basis of arsenic trioxide (ATO) effects on LPS-dependent expression of interleukin-8 (IL-8) gene in human monocytic cells.	Arsenic Trioxide	55-71	C-X-C motif chemokine ligand 8	Homo sapiens	117-130	
21777978-7	2011	ATO increases LPS-dependent expression of IL-8 by enhancing p38-kinase activity induced by LPS in U937 cells.	Arsenic Trioxide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	42-46	
21777978-10	2011	In addition, it markedly prevents the increase of both p38-kinase phosphorylation and IL-8 gene expression in LPS-stimulated cells pre-treated with ATO.	Arsenic Trioxide	148-151	C-X-C motif chemokine ligand 8	Homo sapiens	86-90	
21777978-12	2011	In conclusion, our study demonstrates that ATO increases LPS-dependent expression of the inflammatory IL-8 gene by strengthening the p38 kinase activity induced by LPS through stimulation of a ROS/Src kinase signalling pathway.	Arsenic Trioxide	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	102-106	
21777978-4	2011	In the present study, we determined molecular basis of arsenic trioxide (ATO) effects on LPS-dependent expression of interleukin-8 (IL-8) gene in human monocytic cells.	Arsenic Trioxide	55-71	C-X-C motif chemokine ligand 8	Homo sapiens	132-136	
21777978-4	2011	In the present study, we determined molecular basis of arsenic trioxide (ATO) effects on LPS-dependent expression of interleukin-8 (IL-8) gene in human monocytic cells.	Arsenic Trioxide	73-76	C-X-C motif chemokine ligand 8	Homo sapiens	117-130	
21777978-4	2011	In the present study, we determined molecular basis of arsenic trioxide (ATO) effects on LPS-dependent expression of interleukin-8 (IL-8) gene in human monocytic cells.	Arsenic Trioxide	73-76	C-X-C motif chemokine ligand 8	Homo sapiens	132-136	
21777978-5	2011	Pre-treatment with non cytotoxic concentrations of ATO for 48h increase IL-8 gene expression induced by LPS in monocytic U937 cells and in some, but not all, primary cultures of blood monocytes.	Arsenic Trioxide	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	72-76	
26276563-11	2016	The results showed that the expression levels of IL-6, IL-8, TNF-alpha, and NF-kappaB which seemed to be a critical mediator in the inflammatory response tended to increase in the birds chronically treated with As2O3.	Arsenic Trioxide	211-216	C-X-C motif chemokine ligand 8	Homo sapiens	55-59	
20501519-6	2011	Using an antibody array approach, we found that ATO increased the production of several cytokines, with interleukin 8 (IL-8) being the predominant one.	Arsenic Trioxide	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	104-117	
20501519-6	2011	Using an antibody array approach, we found that ATO increased the production of several cytokines, with interleukin 8 (IL-8) being the predominant one.	Arsenic Trioxide	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	119-123	
20501519-7	2011	We confirmed that ATO increased the production of IL-8 by enzyme-linked-immunosorbent assay (ELISA).	Arsenic Trioxide	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	50-54	
20501519-10	2011	Also, we conclude that the production of IL-8 is not induced by a caspase-4-dependent mechanism, suggesting that ATO-induced caspase-4 activation is involved in other as yet unidentified functions in human neutrophils.	Arsenic Trioxide	113-116	C-X-C motif chemokine ligand 8	Homo sapiens	41-45	
16920938-6	2006	In addition, As2O3 reduced expression of various macrophagic surface markers, enhanced that of the monocytic marker CD14, and altered both endocytosis and phagocytosis; unexpectedly, exposure of macrophages to the metalloid also strongly potentiated expression of TNFalpha and IL-8 induced by LPS.	Arsenic Trioxide	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	277-281	
14642127-6	2003	RESULTS: After 96 hours exposure to arsenic trioxide, 10 - 6 mol/L in vitro or 10 mg/d in vivo, APL cells showed a significant increase of IL-1(beta) (P < 0.05) and G-CSF (P < 0.05) production, and a significant decrease of IL-6 (P < 0.05) and IL-8 (P < 0.05).	Arsenic Trioxide	36-52	C-X-C motif chemokine ligand 8	Homo sapiens	253-257