PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25082385-9 2015 ATO treatment suppressed the invasiveness of osteosarcoma cells by inhibiting the transcriptional activity of GLI2. Arsenic Trioxide 0-3 GLI family zinc finger 2 Homo sapiens 110-114 26708503-4 2016 Treatment of THP-1 cells with ethionamide, for instance, significantly reduced mRNA expression of multiple ARE-driven genes under either basal or As2O3-challenged conditions. Arsenic Trioxide 146-151 GLI family zinc finger 2 Homo sapiens 13-18 26708503-5 2016 As determined by cell viability and cell cycle, suppression of NRF2-ARE by ethionamide also significantly enhanced susceptibility of THP-1 and U937 cells to As2O3-induced cytotoxicity. Arsenic Trioxide 157-162 GLI family zinc finger 2 Homo sapiens 133-138 26708503-6 2016 In THP-1 cells, the sensitizing effect of ethionamide on As2O3-induced cytotoxicity was highly dependent on NRF2. Arsenic Trioxide 57-62 GLI family zinc finger 2 Homo sapiens 3-8 33879448-5 2021 Targeting GLI2 with arsenic trioxide caused extended survival of tumor-bearing animals, indicating a potential therapeutic vulnerability in ZFTA fusion-positive tumors. Arsenic Trioxide 20-36 GLI family zinc finger 2 Homo sapiens 10-14 23253724-0 2012 Arsenic trioxide regulates the production and activities of matrix metalloproteinases-1, -2, and -9 in fibroblasts and THP-1. Arsenic Trioxide 0-16 GLI family zinc finger 2 Homo sapiens 119-124 24944602-0 2014 Arsenic trioxide induces apoptosis in the THP1 cell line by downregulating EVI-1. Arsenic Trioxide 0-16 GLI family zinc finger 2 Homo sapiens 42-46 24944602-4 2014 ATO treatment was shown to inhibit proliferation and induce apoptosis in THP1 cells in a dose- and time-dependent manner. Arsenic Trioxide 0-3 GLI family zinc finger 2 Homo sapiens 73-77 24944602-7 2014 These results indicated that ATO inhibited the proliferation and induced apoptosis in THP1 cells partially via blocking the inhibitory effects of EVI-1 on the JNK signaling pathway with the involvement of apoptosis-associated proteins, including Bax, Bcl-2, Bcl-xL and caspase-3. Arsenic Trioxide 29-32 GLI family zinc finger 2 Homo sapiens 86-90 23253724-10 2012 RESULTS: As2O3 inhibited the expression of MMP-1, MMP-2 and MMP-9 mRNA, the secretion and activity of MMP-1, MMP-2 and MMP-9 in HSFb and THP-1 cells in the inflammatory state (P < 0.05 and P < 0.01 respectively). Arsenic Trioxide 9-14 GLI family zinc finger 2 Homo sapiens 137-142 23253724-13 2012 CONCLUSIONS: As2O3, as a main component of arsenolite, can inhibit the production of MMPs by HSFb and THP-1 cells in an inflammatory state through inhibiting the release of inflammatory factors and the activation of the MAPK cascade pathway. Arsenic Trioxide 13-18 GLI family zinc finger 2 Homo sapiens 102-107 23253724-13 2012 CONCLUSIONS: As2O3, as a main component of arsenolite, can inhibit the production of MMPs by HSFb and THP-1 cells in an inflammatory state through inhibiting the release of inflammatory factors and the activation of the MAPK cascade pathway. Arsenic Trioxide 43-53 GLI family zinc finger 2 Homo sapiens 102-107 21315065-0 2011 Lipoic acid ameliorates arsenic trioxide-induced HO-1 expression and oxidative stress in THP-1 monocytes and macrophages. Arsenic Trioxide 24-40 GLI family zinc finger 2 Homo sapiens 89-94 23259068-3 2012 ATRA and ATO induce Ser-51 phosphorylation (inactivation) of eIF2alpha, through the induction of protein kinase C delta (PKCdelta) and PKR, but not other eIF2alpha kinases, such as GCN2 and PERK in APL (NB4) and AML cells (HL60, U937, and THP-1). Arsenic Trioxide 9-12 GLI family zinc finger 2 Homo sapiens 239-244 21078271-0 2010 [Acetyl-11-keto-beta-boswellic acid and arsenic trioxide regulate the productions and activities of matrix metalloproteinases in human skin fibroblasts and human leukemia cell line THP-1]. Arsenic Trioxide 40-56 GLI family zinc finger 2 Homo sapiens 181-186 21078271-8 2010 RESULTS: Compound of AKBA and ATO inhibited MMP-1, MMP-2 and MMP-9 mRNA expressions, secretions and activities respectively in HSFbs and THP-1 cells in inflammatory state (P<0.05, P<0.01). Arsenic Trioxide 30-33 GLI family zinc finger 2 Homo sapiens 137-142 21078271-9 2010 Also compound of AKBA and ATO inhibited secretions of TNF-alpha and IL-1beta in THP-1 cells and cell coculture system (P<0.01). Arsenic Trioxide 26-29 GLI family zinc finger 2 Homo sapiens 80-85 18359480-2 2008 The present work demonstrates that the flavonoids quercetin and chrysin cooperate with ATO to induce apoptosis in U937 promonocytes and other human leukemia cell lines (THP-1, HL-60). Arsenic Trioxide 87-90 GLI family zinc finger 2 Homo sapiens 169-174