PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23542114-5 2013 ATO inhibited the phosphorylation and activation of AKT and STAT3 through Notch signaling blockade. Arsenic Trioxide 0-3 signal transducer and activator of transcription 3 Homo sapiens 60-65 17404111-1 2007 PURPOSE: Constitutive signal transducer and activator of transcription 3 (STAT3) activity, observed in approximately 50% of acute myelogenous leukemia cases and associated with adverse treatment outcome, is down-regulated by arsenic trioxide (ATO). Arsenic Trioxide 225-241 signal transducer and activator of transcription 3 Homo sapiens 22-72 17404111-1 2007 PURPOSE: Constitutive signal transducer and activator of transcription 3 (STAT3) activity, observed in approximately 50% of acute myelogenous leukemia cases and associated with adverse treatment outcome, is down-regulated by arsenic trioxide (ATO). Arsenic Trioxide 225-241 signal transducer and activator of transcription 3 Homo sapiens 74-79 17404111-1 2007 PURPOSE: Constitutive signal transducer and activator of transcription 3 (STAT3) activity, observed in approximately 50% of acute myelogenous leukemia cases and associated with adverse treatment outcome, is down-regulated by arsenic trioxide (ATO). Arsenic Trioxide 243-246 signal transducer and activator of transcription 3 Homo sapiens 22-72 17404111-1 2007 PURPOSE: Constitutive signal transducer and activator of transcription 3 (STAT3) activity, observed in approximately 50% of acute myelogenous leukemia cases and associated with adverse treatment outcome, is down-regulated by arsenic trioxide (ATO). Arsenic Trioxide 243-246 signal transducer and activator of transcription 3 Homo sapiens 74-79 17404111-6 2007 RESULTS: Pharmacodynamic interaction of ATO and three HSP90 inhibitors showed synergistic interactions in inhibiting constitutive STAT3 activity and inducing cell death, in spite of a concurrent synergistic up-regulation of HSP70. Arsenic Trioxide 40-43 signal transducer and activator of transcription 3 Homo sapiens 130-135 17404111-7 2007 CONCLUSIONS: These preliminary results provide a basis for studying the combined role of ATO with HSP90 inhibitors in acute myelogenous leukemia with constitutive STAT3 activity. Arsenic Trioxide 89-92 signal transducer and activator of transcription 3 Homo sapiens 163-168 17121903-5 2006 We hypothesized that arsenic trioxide inhibits protein tyrosine kinases (PTK), which, among others, phosphorylate and activate STATs. Arsenic Trioxide 21-37 signal transducer and activator of transcription 3 Homo sapiens 127-132 17121903-7 2006 Arsenic trioxide reduced STAT3 activation by Janus kinases, altered phosphorylation and electrophoretic mobility of ZNF198/fibroblast growth factor receptor 1, reduced kinase protein level, and decreased STAT3 protein phosphorylation. Arsenic Trioxide 0-16 signal transducer and activator of transcription 3 Homo sapiens 25-30 17121903-7 2006 Arsenic trioxide reduced STAT3 activation by Janus kinases, altered phosphorylation and electrophoretic mobility of ZNF198/fibroblast growth factor receptor 1, reduced kinase protein level, and decreased STAT3 protein phosphorylation. Arsenic Trioxide 0-16 signal transducer and activator of transcription 3 Homo sapiens 204-209 34749590-9 2021 Notably, interferon alpha and/or arsenic trioxide inhibited megakaryocytes proliferation and reduced JAK2, STAT3, STAT5 and AKT phosphorylation in mutant JAK2-expressing iPSCs compared with those without induction. Arsenic Trioxide 33-49 signal transducer and activator of transcription 3 Homo sapiens 107-112 33634982-0 2021 Arsenic trioxide induces differentiation of cancer stem cells in hepatocellular carcinoma through inhibition of LIF/JAK1/STAT3 and NF-kB signaling pathways synergistically. Arsenic Trioxide 0-16 signal transducer and activator of transcription 3 Homo sapiens 121-126 33634982-8 2021 Synergistic inhibition of the LIF/JAK1/STAT3 and NF-kB signaling pathways by ATO and 5-FU/cisplatin is a potential molecular mechanism underlying the differentiation effect. Arsenic Trioxide 77-80 signal transducer and activator of transcription 3 Homo sapiens 39-44 33634982-9 2021 CONCLUSIONS: ATO induced the differentiation of HCC CSCs and potentiated the cytotoxic effects of 5-FU/cisplatin through synergistic inhibition of the LIF/JAK1/STAT3 and NF-kB signaling pathways. Arsenic Trioxide 13-16 signal transducer and activator of transcription 3 Homo sapiens 160-165 32351887-0 2020 Combinatorial Low Dose Arsenic Trioxide and Cisplatin Exacerbates Autophagy via AMPK/STAT3 Signaling on Targeting Head and Neck Cancer Initiating Cells. Arsenic Trioxide 23-39 signal transducer and activator of transcription 3 Homo sapiens 85-90 31177080-0 2019 Arsenic trioxide improves Treg and Th17 balance by modulating STAT3 in treatment-naive rheumatoid arthritis patients. Arsenic Trioxide 0-16 signal transducer and activator of transcription 3 Homo sapiens 62-67 31177080-1 2019 OBJECTIVE: We aimed to investigate the immunologic mechanisms by which arsenic trioxide (As2O3) may inhibit T helper 17 (Th17) cell differentiation while promoting regulatory T (Treg) cell generation by modulating signal transducer and activator of transcription 3 (STAT3) in treatment-naive rheumatoid arthritis (RA) patients. Arsenic Trioxide 71-87 signal transducer and activator of transcription 3 Homo sapiens 214-264 31177080-1 2019 OBJECTIVE: We aimed to investigate the immunologic mechanisms by which arsenic trioxide (As2O3) may inhibit T helper 17 (Th17) cell differentiation while promoting regulatory T (Treg) cell generation by modulating signal transducer and activator of transcription 3 (STAT3) in treatment-naive rheumatoid arthritis (RA) patients. Arsenic Trioxide 71-87 signal transducer and activator of transcription 3 Homo sapiens 266-271 31177080-1 2019 OBJECTIVE: We aimed to investigate the immunologic mechanisms by which arsenic trioxide (As2O3) may inhibit T helper 17 (Th17) cell differentiation while promoting regulatory T (Treg) cell generation by modulating signal transducer and activator of transcription 3 (STAT3) in treatment-naive rheumatoid arthritis (RA) patients. Arsenic Trioxide 89-94 signal transducer and activator of transcription 3 Homo sapiens 214-264 31177080-1 2019 OBJECTIVE: We aimed to investigate the immunologic mechanisms by which arsenic trioxide (As2O3) may inhibit T helper 17 (Th17) cell differentiation while promoting regulatory T (Treg) cell generation by modulating signal transducer and activator of transcription 3 (STAT3) in treatment-naive rheumatoid arthritis (RA) patients. Arsenic Trioxide 89-94 signal transducer and activator of transcription 3 Homo sapiens 266-271 31177080-5 2019 RESULTS: We found that As2O3 prevented activated naive CD4+T-cells from differentiating into Th17 cells and reduced cytokine production by activated Th17 cells by downregulating their signature transcription factors, STAT3 and orphan nuclear receptors. Arsenic Trioxide 23-28 signal transducer and activator of transcription 3 Homo sapiens 217-222 31177080-6 2019 Notably, As2O3 reduced Th17 cells frequency while increasing Treg cells frequency under specific polarizing conditions in treatment-naive RA patients by transfecting siRNA STAT3 and lentivirus STAT3. Arsenic Trioxide 9-14 signal transducer and activator of transcription 3 Homo sapiens 172-177 31177080-6 2019 Notably, As2O3 reduced Th17 cells frequency while increasing Treg cells frequency under specific polarizing conditions in treatment-naive RA patients by transfecting siRNA STAT3 and lentivirus STAT3. Arsenic Trioxide 9-14 signal transducer and activator of transcription 3 Homo sapiens 193-198 31177080-8 2019 CONCLUSIONS: These data indicate that As2O3 may be a potential immune modulator for treatment-naive RA patients that helps to balance of Treg and Th17 cells through modulating STAT3. Arsenic Trioxide 38-43 signal transducer and activator of transcription 3 Homo sapiens 176-181 30012499-0 2018 Blockade of JAK2/STAT3 intensifies the anti-tumor activity of arsenic trioxide in acute myeloid leukemia cells: Novel synergistic mechanism via the mediation of reactive oxygen species. Arsenic Trioxide 62-78 signal transducer and activator of transcription 3 Homo sapiens 17-22 29409467-0 2018 Arsenic trioxide attenuates STAT-3 activity and epithelial-mesenchymal transition through induction of SHP-1 in gastric cancer cells. Arsenic Trioxide 0-16 signal transducer and activator of transcription 3 Homo sapiens 28-34 29409467-1 2018 BACKGROUND: We investigated the effect of arsenic trioxide (ATO) for inhibition of signal transducer and activator of transcription 3 (STAT3) and epithelial-mesenchymal transition (EMT) in gastric cancer cells, and the role of SH2 domain-containing phosphatase-1 (SHP-1) during this process. Arsenic Trioxide 42-58 signal transducer and activator of transcription 3 Homo sapiens 83-133 29409467-1 2018 BACKGROUND: We investigated the effect of arsenic trioxide (ATO) for inhibition of signal transducer and activator of transcription 3 (STAT3) and epithelial-mesenchymal transition (EMT) in gastric cancer cells, and the role of SH2 domain-containing phosphatase-1 (SHP-1) during this process. Arsenic Trioxide 42-58 signal transducer and activator of transcription 3 Homo sapiens 135-140 29409467-1 2018 BACKGROUND: We investigated the effect of arsenic trioxide (ATO) for inhibition of signal transducer and activator of transcription 3 (STAT3) and epithelial-mesenchymal transition (EMT) in gastric cancer cells, and the role of SH2 domain-containing phosphatase-1 (SHP-1) during this process. Arsenic Trioxide 60-63 signal transducer and activator of transcription 3 Homo sapiens 83-133 29409467-1 2018 BACKGROUND: We investigated the effect of arsenic trioxide (ATO) for inhibition of signal transducer and activator of transcription 3 (STAT3) and epithelial-mesenchymal transition (EMT) in gastric cancer cells, and the role of SH2 domain-containing phosphatase-1 (SHP-1) during this process. Arsenic Trioxide 60-63 signal transducer and activator of transcription 3 Homo sapiens 135-140 29409467-7 2018 Western blot showed that ATO upregulated SHP-1 expression and downregulated STAT3 expression, and immunofluorescence showed upregulation with E-cadherin (epithelial marker) and downregulation of Snail1 (mesenchymal marker) expression by ATO treatment. Arsenic Trioxide 25-28 signal transducer and activator of transcription 3 Homo sapiens 76-81 29409467-8 2018 Anti-migration and invasion effect and modulation of SHP-1/STAT3 axis by ATO were attenuated by pervanadate or SHP-1 siRNA. Arsenic Trioxide 73-76 signal transducer and activator of transcription 3 Homo sapiens 59-64 29409467-10 2018 CONCLUSION: Our data suggest that ATO inhibits STAT3 activity and EMT process by upregulation of SHP-1 in gastric cancer cells. Arsenic Trioxide 34-37 signal transducer and activator of transcription 3 Homo sapiens 47-52 28278714-0 2017 Cucurbitacin B synergistically enhances the apoptosis-inducing effect of arsenic trioxide by inhibiting STAT3 phosphorylation in lymphoma Ramos cells. Arsenic Trioxide 73-89 signal transducer and activator of transcription 3 Homo sapiens 104-109 28278714-2 2017 However, the therapeutic effect of ATO is limited in lymphoma, which resists apoptosis possibly due to inappropriate activation of STAT3. Arsenic Trioxide 35-38 signal transducer and activator of transcription 3 Homo sapiens 131-136 28278714-7 2017 Collectively, CuB synergistically enhances the apoptosis-inducing effect of ATO by inhibiting STAT3 phosphorylation in Ramos cells. Arsenic Trioxide 76-79 signal transducer and activator of transcription 3 Homo sapiens 94-99 28187727-0 2017 Cryptotanshinone enhances the effect of Arsenic trioxide in treating liver cancer cell by inducing apoptosis through downregulating phosphorylated- STAT3 in vitro and in vivo. Arsenic Trioxide 40-56 signal transducer and activator of transcription 3 Homo sapiens 148-153 28187727-3 2017 Here we try to elucidate how CT could enhance the efficacy of ATO for treating liver cancer and its correlation to STAT3 in vitro and in vivo. Arsenic Trioxide 62-65 signal transducer and activator of transcription 3 Homo sapiens 115-120 28187727-11 2017 We also found that ATO combined with CT reversed the upregulated expression of phosphorylated-STAT3Tyr705 stimulated by interleukin-6 and downregulated STAT3 direct target genes and the anti-apoptotic proteins Bcl-2, XIAP, and survivin but obviously upregulated the promoting apoptosis proteins Bak,.In vivo studies showed that ATO combined with CT decreased tumor growth. Arsenic Trioxide 19-22 signal transducer and activator of transcription 3 Homo sapiens 94-99 28187727-11 2017 We also found that ATO combined with CT reversed the upregulated expression of phosphorylated-STAT3Tyr705 stimulated by interleukin-6 and downregulated STAT3 direct target genes and the anti-apoptotic proteins Bcl-2, XIAP, and survivin but obviously upregulated the promoting apoptosis proteins Bak,.In vivo studies showed that ATO combined with CT decreased tumor growth. Arsenic Trioxide 328-331 signal transducer and activator of transcription 3 Homo sapiens 94-99 27576314-12 2016 CONCLUSIONS: These findings, for the first time, provides evidence that the miR-125b-mediated inhibition of Stat3 is involved in the ATO-induced attenuation of metastasis in chondrosarcoma cells. Arsenic Trioxide 133-136 signal transducer and activator of transcription 3 Homo sapiens 108-113 21456022-0 2011 Phase 1 study of arsenic trioxide, high-dose cytarabine, and idarubicin to down-regulate constitutive signal transducer and activator of transcription 3 activity in patients aged <60 years with acute myeloid leukemia. Arsenic Trioxide 17-33 signal transducer and activator of transcription 3 Homo sapiens 102-152 21456022-2 2011 In vitro treatment of AML blasts with arsenic trioxide (ATO) down-regulated STAT3 activity within 6 hours associated with a reduced viability within 48 hours. Arsenic Trioxide 38-54 signal transducer and activator of transcription 3 Homo sapiens 76-81 21456022-2 2011 In vitro treatment of AML blasts with arsenic trioxide (ATO) down-regulated STAT3 activity within 6 hours associated with a reduced viability within 48 hours. Arsenic Trioxide 56-59 signal transducer and activator of transcription 3 Homo sapiens 76-81 20035426-0 2010 Down-regulation of heat shock protein 70 improves arsenic trioxide and 17-DMAG effects on constitutive signal transducer and activator of transcription 3 activity. Arsenic Trioxide 50-66 signal transducer and activator of transcription 3 Homo sapiens 103-153 20035426-2 2010 Arsenic trioxide (ATO) synergizes with the heat shock protein (HSP) 90 inhibitor, 17-DMAG, to down-regulate STAT3 activity. Arsenic Trioxide 0-16 signal transducer and activator of transcription 3 Homo sapiens 108-113 20035426-2 2010 Arsenic trioxide (ATO) synergizes with the heat shock protein (HSP) 90 inhibitor, 17-DMAG, to down-regulate STAT3 activity. Arsenic Trioxide 18-21 signal transducer and activator of transcription 3 Homo sapiens 108-113 20035426-5 2010 EXPERIMENTAL DESIGN: A semi-mechanistic pharmacodynamic model was used to characterize concentration-effect relationships of ATO and 17-DMAG effects on constitutive STAT3 activity and HSP70 expression with or without siRNA against HSP70 in a cell line model. Arsenic Trioxide 125-128 signal transducer and activator of transcription 3 Homo sapiens 165-170 20035426-6 2010 RESULTS: Treatment with siRNA for HSP70 resulted in a stronger degree of synergism on down-regulation of STAT3 activity by ATO and 17-DMAG. Arsenic Trioxide 123-126 signal transducer and activator of transcription 3 Homo sapiens 105-110 23382965-0 2013 Expression of AFP and STAT3 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in AFP-producing gastric cancer cells. Arsenic Trioxide 43-59 signal transducer and activator of transcription 3 Homo sapiens 22-27 23382965-9 2013 Downregulation of AFP and STAT3 expression plays an important role in As(2)O(3)-induced apoptosis of AFPGC cells, which suggests a new mechanism of As(2)O(3)-induced cell apoptosis. Arsenic Trioxide 70-79 signal transducer and activator of transcription 3 Homo sapiens 26-31 23382965-9 2013 Downregulation of AFP and STAT3 expression plays an important role in As(2)O(3)-induced apoptosis of AFPGC cells, which suggests a new mechanism of As(2)O(3)-induced cell apoptosis. Arsenic Trioxide 148-157 signal transducer and activator of transcription 3 Homo sapiens 26-31