PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23832679-9	2013	Exposure of hCD133(+) -C6 to arsenic trioxide not only reduced Akt phosphorylation, Notch-1 activation and Hes-1 expression in vitro, but also inhibited their tumorigenicity in vivo.	Arsenic Trioxide	29-45	AKT serine/threonine kinase 1	Rattus norvegicus	63-66	
32919218-14	2020	Moreover, Crt treatment stimulated the expressions of P-PI3K, PI3K, P-AKT, AKT induced by ATO.	Arsenic Trioxide	90-93	AKT serine/threonine kinase 1	Rattus norvegicus	70-73	
27980225-0	2017	Melatonin protects against arsenic trioxide-induced liver injury by the upregulation of Nrf2 expression through the activation of PI3K/AKT pathway.	Arsenic Trioxide	27-43	AKT serine/threonine kinase 1	Rattus norvegicus	135-138	
27980225-10	2017	In conclusion, our results indicated that melatonin protected against As2O3-induced liver injury by inducing Nrf2/HO-1 expression via upregulation of PI3K/AKT pathway.	Arsenic Trioxide	70-75	AKT serine/threonine kinase 1	Rattus norvegicus	155-158	
27664319-0	2016	Arsenic trioxide mediates HAPI microglia inflammatory response and the secretion of inflammatory cytokine IL-6 via Akt/NF-kappaB signaling pathway.	Arsenic Trioxide	0-16	AKT serine/threonine kinase 1	Rattus norvegicus	115-118	
27664319-8	2016	Besides, Akt blocker LY294002 also obviously attenuated NF-kB activation and transnuclear induced by Arsenic trioxide.	Arsenic Trioxide	101-117	AKT serine/threonine kinase 1	Rattus norvegicus	9-12	
27664319-9	2016	In concert with these results, we highlighted that the secretion of pro-inflammatory cytokine and NF-kB activation induced by Arsenic trioxide can be mediated by elevation of p-Akt in HAPI microglia cells.	Arsenic Trioxide	126-142	AKT serine/threonine kinase 1	Rattus norvegicus	177-180	
27671604-6	2016	As2O3 activated the AKT/GSK-3beta/Snail signaling pathway, and blocking this pathway with PI3K inhibitor (LY294002) abolished EndMT in As2O3-treated endothelial cells.	Arsenic Trioxide	0-5	AKT serine/threonine kinase 1	Rattus norvegicus	20-23	
27671604-6	2016	As2O3 activated the AKT/GSK-3beta/Snail signaling pathway, and blocking this pathway with PI3K inhibitor (LY294002) abolished EndMT in As2O3-treated endothelial cells.	Arsenic Trioxide	135-140	AKT serine/threonine kinase 1	Rattus norvegicus	20-23	
21180886-0	2011	E3 ubiquitin ligase Cbl-b potentiates the apoptotic action of arsenic trioxide by inhibiting the PI3K/Akt pathway.	Arsenic Trioxide	62-78	AKT serine/threonine kinase 1	Rattus norvegicus	102-105	
21180886-2	2011	Inducible phosphatidyl inositol 3 kinase (PI3K)-Akt activation promotes resistance to ATO.	Arsenic Trioxide	86-89	AKT serine/threonine kinase 1	Rattus norvegicus	48-51	
21180886-7	2011	The PI3K/Akt inhibitor, LY294002, significantly increased ATO-induced apoptosis (P < 0.05).	Arsenic Trioxide	58-61	AKT serine/threonine kinase 1	Rattus norvegicus	9-12	
21180886-10	2011	ATO induced cellular apoptosis with transient activation of Akt and Cbl-b was also up-regulated.	Arsenic Trioxide	0-3	AKT serine/threonine kinase 1	Rattus norvegicus	60-63	
21180886-13	2011	The PI3K/Akt inhibitor, LY294002, re-sensitized Cbl-b (DN) overexpressing cells to ATO and reversed G2/M arrest (P < 0.05).	Arsenic Trioxide	83-86	AKT serine/threonine kinase 1	Rattus norvegicus	9-12	
21180886-14	2011	Taken together, these results suggest that Cbl-b potentiates the apoptotic action of ATO by inhibition of the PI3K/Akt pathway.	Arsenic Trioxide	85-88	AKT serine/threonine kinase 1	Rattus norvegicus	115-118