PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33919717-0 2021 Gene Amplification-Associated Overexpression of the Selenoprotein tRNA Enzyme TRIT1 Confers Sensitivity to Arsenic Trioxide in Small-Cell Lung Cancer. Arsenic Trioxide 107-123 tRNA isopentenyltransferase 1 Homo sapiens 78-83 33919717-6 2021 We observed that TRIT1-amplified cells are sensitive to arsenic trioxide, a compound that regulates selenoproteins, whereas reduction of TRIT1 levels confers loss of sensitivity to the drug. Arsenic Trioxide 56-72 tRNA isopentenyltransferase 1 Homo sapiens 17-22 33919717-7 2021 Overall, our results indicate a role for TRIT1 as a small-cell lung cancer-relevant gene that, when undergoing gene amplification-associated activation, can be targeted with the differentiation agent arsenic trioxide. Arsenic Trioxide 200-216 tRNA isopentenyltransferase 1 Homo sapiens 41-46