PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25728215-4 2016 SiHa cells treated with low concentrations of humic acid and arsenic trioxide alone or in co-exposure significantly increased reactive oxygen species, glutathione levels, cell proliferation, scratch wound-healing activities, migration abilities, and MMP-2 expression as compared to the untreated control. Arsenic Trioxide 61-77 matrix metallopeptidase 2 Homo sapiens 250-255 17650671-7 2007 (3) The activity of MMP-2 and 9 was partly inhibited by 0.05 micromol/L As2 O3 incubated 72 hours and by 0.4, 3.2 micromol/L, As2 O3. Arsenic Trioxide 72-78 matrix metallopeptidase 2 Homo sapiens 20-31 27039805-5 2016 Moreover, ATO significantly increased adhesion of U87MG cells and also diminished transcription of NF-kappaB down-stream targets involved in cell migration and invasion, including cathepsin B, uPA, MMP-2, MMP-9 and MMP-14 and suppressed proteolytic activity of cathepsin B, MMP-2 and MMP-9, demonstrating a possible mechanism of ATO effect on a well-known signaling in glioblastoma dissemination. Arsenic Trioxide 10-13 matrix metallopeptidase 2 Homo sapiens 198-203 27039805-5 2016 Moreover, ATO significantly increased adhesion of U87MG cells and also diminished transcription of NF-kappaB down-stream targets involved in cell migration and invasion, including cathepsin B, uPA, MMP-2, MMP-9 and MMP-14 and suppressed proteolytic activity of cathepsin B, MMP-2 and MMP-9, demonstrating a possible mechanism of ATO effect on a well-known signaling in glioblastoma dissemination. Arsenic Trioxide 10-13 matrix metallopeptidase 2 Homo sapiens 274-279 27039805-6 2016 Taken together, here we suggest that ATO inhibits survival and invasion of U87MG cells possibly through NF-kappaB-mediated inhibition of survivin and telomerase activity and NF-kappaB-dependent suppression of cathepsin B, MMP-2 and MMP-9. Arsenic Trioxide 37-40 matrix metallopeptidase 2 Homo sapiens 222-227 24680928-5 2014 Here we found that As2O3 attenuated the migration/invasion potential of HCC cell lines by blocking matrix metalloproteinases (MMPs) activities and inducing a mesenchymal to epithelial transition (MET). Arsenic Trioxide 19-24 matrix metallopeptidase 2 Homo sapiens 126-130 24680928-9 2014 Knockdown of miR-491 abolished the As2O3-induced MMPs inactivation, MET, and the migration/invasion potential of HCC cell lines. Arsenic Trioxide 35-40 matrix metallopeptidase 2 Homo sapiens 49-53 23253724-3 2012 This research was designed to evaluate the effects of As2O3 on production and activities of MMP-1, MMP-2 and MMP-9, and on regulation of its signal transduction pathway in human skin fibroblasts (HSFb) and human monocyte line (THP-1 cells) that were in an inflammatory state. Arsenic Trioxide 54-59 matrix metallopeptidase 2 Homo sapiens 99-104 23253724-10 2012 RESULTS: As2O3 inhibited the expression of MMP-1, MMP-2 and MMP-9 mRNA, the secretion and activity of MMP-1, MMP-2 and MMP-9 in HSFb and THP-1 cells in the inflammatory state (P < 0.05 and P < 0.01 respectively). Arsenic Trioxide 9-14 matrix metallopeptidase 2 Homo sapiens 50-55 23253724-10 2012 RESULTS: As2O3 inhibited the expression of MMP-1, MMP-2 and MMP-9 mRNA, the secretion and activity of MMP-1, MMP-2 and MMP-9 in HSFb and THP-1 cells in the inflammatory state (P < 0.05 and P < 0.01 respectively). Arsenic Trioxide 9-14 matrix metallopeptidase 2 Homo sapiens 109-114 21078271-8 2010 RESULTS: Compound of AKBA and ATO inhibited MMP-1, MMP-2 and MMP-9 mRNA expressions, secretions and activities respectively in HSFbs and THP-1 cells in inflammatory state (P<0.05, P<0.01). Arsenic Trioxide 30-33 matrix metallopeptidase 2 Homo sapiens 51-56 17650671-0 2007 [Effect of arsenic trioxide on VEGF/R and MMP-2, 9 expressed in K562 cells]. Arsenic Trioxide 11-27 matrix metallopeptidase 2 Homo sapiens 42-47 17650671-1 2007 OBJECTIVE: To explore the effect of arsenic trioxide (As2 O3) on the level of VEGF, VEGFR and the activity of MMP-2, 9 in K562 cells. Arsenic Trioxide 36-52 matrix metallopeptidase 2 Homo sapiens 110-115 21540248-0 2011 Arsenic trioxide inhibits invasion/migration in SGC-7901 cells by activating the reactive oxygen species-dependent cyclooxygenase-2/matrix metalloproteinase-2 pathway. Arsenic Trioxide 0-16 matrix metallopeptidase 2 Homo sapiens 132-158 17650671-7 2007 (3) The activity of MMP-2 and 9 was partly inhibited by 0.05 micromol/L As2 O3 incubated 72 hours and by 0.4, 3.2 micromol/L, As2 O3. Arsenic Trioxide 126-132 matrix metallopeptidase 2 Homo sapiens 20-31 17650671-8 2007 With the increase of As2 O3 concentration and the incubation time, the inhibited effect on MMP-2 and 9 was enhanced. Arsenic Trioxide 21-27 matrix metallopeptidase 2 Homo sapiens 91-102 15962302-4 2005 In contrast, As2O3 increased the expression of tissue inhibitor of metalloproteinase (TIMP)-1 and PA inhibitor (PAI)-1, and reduced the MMP-2, -9, and uPA promoter activity in the presence and absence of PMA. Arsenic Trioxide 13-18 matrix metallopeptidase 2 Homo sapiens 136-141 15962302-7 2005 These results suggest that As2O3 inhibits tumor cell invasion by modulating the MMPs/TIMPs and uPA/uPAR/PAI systems of extracellular matrix (ECM) degradation. Arsenic Trioxide 27-32 matrix metallopeptidase 2 Homo sapiens 80-84 34678398-0 2021 MMP2-responsive dual-targeting drug delivery system for valence-controlled arsenic trioxide prodrug delivery against hepatic carcinoma. Arsenic Trioxide 75-91 matrix metallopeptidase 2 Homo sapiens 0-4 35291620-7 2022 Also, it was revealed that NF-kappaB inhibition using Bay 11-7082 enhanced the inhibitory effects of ATO on migration of GBM cells via suppressing the expression of NF-kappaB target genes such as TWIST, MMP2, ICAM-1, and cathepsin B. Arsenic Trioxide 101-104 matrix metallopeptidase 2 Homo sapiens 203-207 33571402-7 2021 Arsenic trioxide was predicted to induce fibrosis by AP1-driven TGFbeta expression and MMP2-driven TGFbeta activation. Arsenic Trioxide 0-16 matrix metallopeptidase 2 Homo sapiens 87-91