PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18996345-8 2008 Simultaneous deletion of five genes encoding ECF-sigma transcription factors, which activate mucin O-glycan utilization, produces defects in bacterial persistence in the gut and in mother-to-offspring transmission. o-glycan 99-107 LOC100508689 Homo sapiens 93-98 19524017-0 2009 Site directed processing: role of amino acid sequences and glycosylation of acceptor glycopeptides in the assembly of extended mucin type O-glycan core 2. o-glycan 138-146 LOC100508689 Homo sapiens 127-132 19524017-5 2009 METHODS: We studied the specificities of four enzymes that synthesize extended O-glycan core 2 using as acceptor substrates synthetic mucin derived peptides and glycopeptides, substituted with GalNAc or O-glycan core structures 1, 2, 3, 4 and 6. o-glycan 79-87 LOC100508689 Homo sapiens 134-139 19191477-0 2009 Structure of a SusD homologue, BT1043, involved in mucin O-glycan utilization in a prominent human gut symbiont. o-glycan 57-65 LOC100508689 Homo sapiens 51-56 20301232-5 2009 In this chapter, however, the term O-glycan refers to mucin O-glycans, unless otherwise specified. o-glycan 35-43 LOC100508689 Homo sapiens 54-59 18769205-6 2008 Alterations in mucin and mucin O-glycan biosynthesis in ocular surface disorders, including allergy, nonautoimmune dry eye, autoimmune dry eye, and infection, are presented. o-glycan 31-39 LOC100508689 Homo sapiens 25-30 12386453-9 2001 The only structural element shared by all mucin O-glycan chains is a GalNAc residue linked to a serine or threonine residue of the apomucin. o-glycan 48-56 LOC100508689 Homo sapiens 42-47 18172093-3 2008 METHODS: Mucin O-glycan biosynthesis in HCLE cells was disrupted by metabolic interference with benzyl-alpha-GalNAc. o-glycan 15-23 LOC100508689 Homo sapiens 9-14 8298304-2 1993 As an approach to study the 3-dimensional interactions between enzymes and O-glycan substrates, we determined the preferred conformations of five oligosaccharide-core structures of mucin type glycoproteins by NMR spectroscopy and by static and dynamic force field calculations. o-glycan 75-83 LOC100508689 Homo sapiens 181-186 9756896-10 1998 These results demonstrate that the O-glycan structures in mucin domains are not necessarily uniformly distributed along the polypeptide core and that their lengths can be modulated by peptide sequence. o-glycan 35-43 LOC100508689 Homo sapiens 58-63 9579575-7 1998 These effects of MUC1 mucin over-expression in MKN74 cells were abolished by the treatment of transfectants with an inhibitor of O-glycan biosynthesis, benzyl-alpha-GalNAc. o-glycan 129-137 LOC100508689 Homo sapiens 22-27 8595262-4 1995 The minimal structure recognized by MeAI on the porcine mucin glycans is the O-glycan core Gal beta 1,3GalNAc-ol, whereas MeAII has a more extended site and interacts with a biantennary O-glycan possessing the terminal trisaccharide Fuc alpha 1,2 (GalNAc alpha 1,3) Gal beta 1,4. o-glycan 186-194 LOC100508689 Homo sapiens 56-61 8595262-4 1995 The minimal structure recognized by MeAI on the porcine mucin glycans is the O-glycan core Gal beta 1,3GalNAc-ol, whereas MeAII has a more extended site and interacts with a biantennary O-glycan possessing the terminal trisaccharide Fuc alpha 1,2 (GalNAc alpha 1,3) Gal beta 1,4. o-glycan 77-85 LOC100508689 Homo sapiens 56-61 34759961-9 2021 "Mucin-Th2" preferentially expressed genes involved in O-glycan biosynthesis and unfolded protein response. o-glycan 55-63 LOC100508689 Homo sapiens 1-6 34648701-6 2021 KEGG and GO analysis indicated that SDF-1 dependent miRNAs changes affect multiple cellular pathways, including fatty acid biosynthesis, thyroid hormone signaling, and mucin-type O-glycan biosynthesis pathways. o-glycan 179-187 LOC100508689 Homo sapiens 168-173 35563881-9 2022 Mucin-type O-glycan branching and increased fucose metabolism are linked to limbal epithelial cell differentiation. o-glycan 11-19 LOC100508689 Homo sapiens 0-5 34561506-9 2021 The related Kyoto encyclopedia of genes and genomes pathways were extracellular matrix-receptor interaction, mucin-type O-glycan biosynthesis, biotin metabolism, and signaling pathways regulating the pluripotency of stem cells. o-glycan 120-128 LOC100508689 Homo sapiens 109-114 35487177-1 2022 For the functional analysis of mucin related glycan, we synthesized core 3 and 5 structures of mucin type O-glycan and investigated their binding interaction with lectins using sugar chip technology. o-glycan 106-114 LOC100508689 Homo sapiens 31-36 35487177-1 2022 For the functional analysis of mucin related glycan, we synthesized core 3 and 5 structures of mucin type O-glycan and investigated their binding interaction with lectins using sugar chip technology. o-glycan 106-114 LOC100508689 Homo sapiens 95-100 34117223-5 2021 A total of 83 O-GalNAc glycans presenting various natural glycan epitopes are obtained and used to generate a unique synthetic mucin O-glycan microarray. o-glycan 133-141 LOC100508689 Homo sapiens 127-132 34083573-10 2021 Pathway enrichment analyses show that mucin-type O-glycan biosynthesis and cardiomyocyte adrenergic signaling (P < 0.001) are downstream of the three validated microRNAs. o-glycan 49-57 LOC100508689 Homo sapiens 38-43 34101390-1 2021 Mucin-type O-glycosylation (O-glycans, O-glycome) is among the most biologically important post-translational modification in glycoproteins but O-glycan structural diversity and expression are poorly understood due to the inadequacy of current analytical methods. o-glycan 144-152 LOC100508689 Homo sapiens 0-5 35287047-0 2022 Synthesis of 2-deoxy mucin-type O-glycan analogues as biological probes. o-glycan 32-40 LOC100508689 Homo sapiens 21-26 35287047-2 2022 Herein, we report the efficient stereoselective synthesis of four novel 2-deoxyglycoside mucin-type O-glycan analogues. o-glycan 100-108 LOC100508689 Homo sapiens 89-94 33978739-6 2021 Our results provide new knowledge on unique glycan-binding specificities for the immune-receptor Dectin-1 towards beta-glucans and the interaction of rotavirus P[19] adhesive protein with mucin O-glycan cores. o-glycan 194-202 LOC100508689 Homo sapiens 188-193 33860037-7 2021 The upregulated tRFs and tiRNAs are mucin-type O-glycan biosynthesis, glycosphingolipid biosynthesis, the glucagon signaling pathway, the AMPK signaling pathway, maturity-onset diabetes of the young, glycosphingolipid biosynthesis, the insulin signaling pathway, insulin resistance, leukocyte transendothelial migration, starch, and sucrose metabolism. o-glycan 47-55 LOC100508689 Homo sapiens 36-41 33925835-10 2021 The mucin-type O-glycan biosynthesis was a high-ranked predicted pathway in CRS patients versus healthy controls (HCs), and the Transforming growth factor beta (TGF-beta) signaling pathway was a high-ranked predicted pathway in CRSwNP versus CRSsNP patients. o-glycan 15-23 LOC100508689 Homo sapiens 4-9 33887693-10 2021 Pathway analysis of the unique target gene GALNT3 linked to hsa-mir-122 showed that GALNT3 influenced the metabolic process of mucin type O-Glycan biosynthesis. o-glycan 138-146 LOC100508689 Homo sapiens 127-132 32776095-1 2021 Aberrant mucin type O-linked glycosylation is a common occurrence in cancer where the upregulation of sialyltransferases is often seen leading to early termination of O-glycan chains. o-glycan 167-175 LOC100508689 Homo sapiens 9-14 31063936-1 2019 The study of mucin O-glycan recognition by glycan-binding proteins has been a challenging area of research at the interface of chemistry and biology. o-glycan 19-27 LOC100508689 Homo sapiens 13-18 33593970-5 2021 The expression of IFN-stimulated genes (ISGs) was upregulated in S. pneumoniae-infected wild-type (WT) but not Ifnar1 -/- mice, including genes involved in mucin type O-glycan biosynthesis; this correlated with an increase in secretions in S. pneumoniae- and IAV-infected WT compared to Ifnar1 -/- pups. o-glycan 167-175 LOC100508689 Homo sapiens 156-161 33123915-8 2021 We identified upregulated pathways including cellular response to endoplasmic reticulum (ER) stress, and mucin-type O-glycan biosynthesis, as well as downregulated pathways of transcriptional misregulation in cancer and T cell receptor signaling. o-glycan 116-124 LOC100508689 Homo sapiens 105-110 33113271-8 2020 Moreover, significant enrichment of KEGG pathways of the DMPs included mucin type O-glycan biosynthesis, focal adhesion, and the insulin signaling pathway. o-glycan 82-90 LOC100508689 Homo sapiens 71-76 32453338-9 2020 The miRNA, miR-543 (target gene: CBX7) was found to be associated with the pathway Mucin type O-glycan biosynthesis. o-glycan 94-102 LOC100508689 Homo sapiens 83-88 31063936-2 2019 Compared with N-glycans, the development of methods for mucin O-glycans has lagged behind and underrepresentation of O-glycans in any of the current microarray libraries have hampered their application in O-glycan recognition studies. o-glycan 62-70 LOC100508689 Homo sapiens 56-61 31063936-7 2019 In this presentation, we overview the current state of play in the construction of O-glycan libraries obtained after their release from mucin glycoproteins and from chemical and chemoenzymatic synthesis for microarray construction using non-covalent and covalent immobilization, and highlight their applications. o-glycan 83-91 LOC100508689 Homo sapiens 136-141 30839226-3 2019 Our results showed that the miR-30a-5p and mucin type O-glycan biosynthesis are closely related to ovarian cancer, and that miR-30a-5p was downregulated in ovarian cancer cells. o-glycan 54-62 LOC100508689 Homo sapiens 43-48 30790320-6 2019 The functional enrichment indicated that the DEGs mainly regulated the pathways of focal adhesion, Mucin type O-glycan biosynthesis, and so on. o-glycan 110-118 LOC100508689 Homo sapiens 99-104 28039261-5 2017 However, O-glycan synthesis enzyme core 2 beta 1,6 N-acetylglucosaminyltransferase (GCNT3/C2GnT-2) is overexpressed in Kras-driven mouse and human cancer, and inhibition of GCNT3 has been shown to disrupt mucin synthesis. o-glycan 9-17 LOC100508689 Homo sapiens 205-210 30396166-8 2018 Significant pathways including the Mucin type O-glycan biosynthesis pathway, cell cycle pathway and cysteine and methionine metabolism pathway (all P< 0.05) revealed potential roles of the target genes of miR-30d-5p in the oncogenesis of NSCLC. o-glycan 46-54 LOC100508689 Homo sapiens 35-40 28894966-6 2017 Naturally occurring 1 and its analog 3 that adopt similar conformation in water bind preferentially L-fucose, and to a lesser degree D-galactose and N-acetyl-D-galactosamine, typically found within the mucin O-glycan core structures. o-glycan 208-216 LOC100508689 Homo sapiens 202-207 28814130-2 2017 However, our knowledge about mucin type O-glycan degradation by bifidobacteria remains fragmentary, especially regarding how they decompose sulfated glycans, which are abundantly found in mucin sugar-chains. o-glycan 40-48 LOC100508689 Homo sapiens 29-34 28187432-9 2017 In addition, the correlative genes of LINC01555 and LINC01207 were enriched in the cAMP signaling and mucin type O-Glycan biosynthesis pathways. o-glycan 113-121 LOC100508689 Homo sapiens 102-107 25727146-5 2015 This chapter describes mucin-type O-glycan biosynthesis, altered mucin-type O-glycans in primary tumors, including mechanisms for structural changes and contributions to the tumor phenotype, and clinical approaches to detect and target altered O-glycans for cancer treatment and management. o-glycan 34-42 LOC100508689 Homo sapiens 23-28 28091546-4 2017 Here we studied the effects of GOS utilization on a prominent gut symbiont, Bacteroides thetaiotaomicron, which has been previously shown to consume HMOs via mucin O-glycan degradation pathways. o-glycan 164-172 LOC100508689 Homo sapiens 158-163 25852737-3 2015 The O-glycan structures present in mucin are diverse and complex, consisting predominantly of core 1-4 mucin-type O-glycans containing alpha- and beta- linked N-acetyl-galactosamine, galactose and N-acetyl-glucosamine. o-glycan 4-12 LOC100508689 Homo sapiens 35-40 25852737-3 2015 The O-glycan structures present in mucin are diverse and complex, consisting predominantly of core 1-4 mucin-type O-glycans containing alpha- and beta- linked N-acetyl-galactosamine, galactose and N-acetyl-glucosamine. o-glycan 4-12 LOC100508689 Homo sapiens 103-108 25086069-0 2014 Restoration of compact Golgi morphology in advanced prostate cancer enhances susceptibility to galectin-1-induced apoptosis by modifying mucin O-glycan synthesis. o-glycan 143-151 LOC100508689 Homo sapiens 137-142 24889612-0 2014 Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILRalpha. o-glycan 52-60 LOC100508689 Homo sapiens 89-94 21883895-7 2012 In conclusion, application of the PLA technique allowed sensitive detection of specific aberrant mucin glycoforms in cancer, increasing specificity to the use of antibodies either to the mucin protein backbone or to the O-glycan haptens alone. o-glycan 220-228 LOC100508689 Homo sapiens 97-102 24138592-0 2014 Loss of gastric gland mucin-specific O-glycan is associated with progression of differentiated-type adenocarcinoma of the stomach. o-glycan 37-45 LOC100508689 Homo sapiens 22-27 24062854-0 2013 Synthesis of mucin-type O-glycan probes as aminopropyl glycosides. o-glycan 24-32 LOC100508689 Homo sapiens 13-18 24820496-8 2014 These differentially expressed genes also took part in cancer related signaling pathways as well, for instance, metabolic pathways, cell cycle, DNA replication, glutathione metabolism, mucin type O-Glycan biosynthesis, drug metabolism-cytochrome P450 and so on. o-glycan 196-204 LOC100508689 Homo sapiens 185-190 21514575-0 2011 Synthesis of mucin O-glycan core structures as their p-nitro- and p-aminophenyl glycosides. o-glycan 19-27 LOC100508689 Homo sapiens 13-18 21514575-1 2011 For the investigation of glycosidases, and for the construction of glycan arrays the p-nitrophenyl- and p-aminophenyl glycosides of mucin O-glycan core structures 1-7 and the 2,6-ST-antigen have been chemically synthesized using d-galactose as a precursor for GalNAc residues. o-glycan 138-146 LOC100508689 Homo sapiens 132-137