PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10821717-1 2000 The search for new small-molecule CCR5 antagonists by high-throughput screening (HTS) of the Takeda chemical library using [(125)I]RANTES and CHO/CCR5 cells led to the discovery of lead compounds (A, B) with a quaternary ammonium or phosphonium moiety, which were synthesized to investigate new MCP-1 receptor antagonists. quaternary ammonium 210-229 C-C chemokine receptor type 5 Cricetulus griseus 34-38