PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20078813-5 2010 After induction with propofol, anesthesia was maintained with 150 microg x kg(-1) x min(-1) propofol infusion. Propofol 92-100 CD59 molecule (CD59 blood group) Homo sapiens 84-90 19627530-10 2010 Propofol maturation has been described with a mature clearance of 1.83 l x min(-1) x 70 kg(-1), a maturation half-time (TM(50)) of 44 weeks and a Hill coefficient of 4.9. Propofol 0-8 CD59 molecule (CD59 blood group) Homo sapiens 75-81 20169954-9 2010 RESULTS: The dose of propofol was less in the PR group than in the PF group (0.10 +/- 0.04 mg x kg(-1) x min(-1) vs. 0.14 +/- 0.04 mg x kg(-1) x min(-1), P = 0.025). Propofol 21-29 CD59 molecule (CD59 blood group) Homo sapiens 105-111 20169954-9 2010 RESULTS: The dose of propofol was less in the PR group than in the PF group (0.10 +/- 0.04 mg x kg(-1) x min(-1) vs. 0.14 +/- 0.04 mg x kg(-1) x min(-1), P = 0.025). Propofol 21-29 CD59 molecule (CD59 blood group) Homo sapiens 145-151 20435936-9 2010 Propofol (C(blood): 1.2 microg x mL(-1)) reduced midazolam central volume of distribution from 5.37 to 2.98 L, elimination clearance from 0.39 to 0.31 L x min(-1), and rapid distribution clearance from 2.77 to 2.11 L x min(-1). Propofol 0-8 CD59 molecule (CD59 blood group) Homo sapiens 155-161 20435936-9 2010 Propofol (C(blood): 1.2 microg x mL(-1)) reduced midazolam central volume of distribution from 5.37 to 2.98 L, elimination clearance from 0.39 to 0.31 L x min(-1), and rapid distribution clearance from 2.77 to 2.11 L x min(-1). Propofol 0-8 CD59 molecule (CD59 blood group) Homo sapiens 219-225 20078813-6 2010 The propofol infusion rate was altered by 20 microg x kg(-1) x min(-1) to maintain the systolic blood pressure within 20% of the baseline (SP group) or BIS value between 45 and 60 (BIS group). Propofol 4-12 CD59 molecule (CD59 blood group) Homo sapiens 63-69 19940820-9 2009 The mean propofol dose was higher in the PVB group (52.03+/-19.32 [35-73] mg x kg x min-1) than in the SA group (44.0+/-18.8 [33-70] mg x kg x min-1) (P=0.002). Propofol 9-17 CD59 molecule (CD59 blood group) Homo sapiens 84-89 19940820-9 2009 The mean propofol dose was higher in the PVB group (52.03+/-19.32 [35-73] mg x kg x min-1) than in the SA group (44.0+/-18.8 [33-70] mg x kg x min-1) (P=0.002). Propofol 9-17 CD59 molecule (CD59 blood group) Homo sapiens 143-148 19639375-11 2009 CONCLUSIONS: An infusion rate of 120 microg x kg(-1) x min(-1) is clinically practical and capable of achieving experimental cardioprotective propofol concentrations at reperfusion. Propofol 142-150 CD59 molecule (CD59 blood group) Homo sapiens 55-61 18539604-4 2008 propofol at an average rate of 10 mg min(-1). Propofol 0-8 CD59 molecule (CD59 blood group) Homo sapiens 37-43 19151272-6 2009 Anesthesia was induced with propofol 2.0 mg/kg and was maintained with a continuous infusion of propofol at a rate of 100-167 microg x kg(-1) x min(-1). Propofol 96-104 CD59 molecule (CD59 blood group) Homo sapiens 144-150 15674525-5 2005 The infusion rate of propofol for achieving the sedation score of level 3 (drowsy, responds to verbal stimulation) was 1.74 +/- 0.82 mg kg(-1) h(-1) (mean +/- SD, n = 7) when the plasma propofol concentration and the total body clearance were 0.85 +/- 0.24 microg ml(-1) and 1.83 +/- 0.54 l min(-1) (mean +/- SD, n =7), respectively. Propofol 21-29 CD59 molecule (CD59 blood group) Homo sapiens 291-297 18270231-9 2008 The EC(50 Propofol) and the k(e0 Propofol) were 5.2 (2.7) microg ml(-1) and 0.60 (0.45) min(-1), respectively. Propofol 10-18 CD59 molecule (CD59 blood group) Homo sapiens 88-94 18270231-9 2008 The EC(50 Propofol) and the k(e0 Propofol) were 5.2 (2.7) microg ml(-1) and 0.60 (0.45) min(-1), respectively. Propofol 33-41 CD59 molecule (CD59 blood group) Homo sapiens 88-94 18270231-10 2008 The k(e0 Propofol) decreased from approximately 0.91 min(-1) at 1 yr to 0.15 min(-1) at 16 yr. Propofol 9-17 CD59 molecule (CD59 blood group) Homo sapiens 53-59 18270231-10 2008 The k(e0 Propofol) decreased from approximately 0.91 min(-1) at 1 yr to 0.15 min(-1) at 16 yr. Propofol 9-17 CD59 molecule (CD59 blood group) Homo sapiens 77-83 17184435-15 2007 The mean dose of propofol required for immobility was 0.119 +/- 0.054 mg x kg(-1) x min(-1) of procedure in T_MLD patients and 0.115 +/- 0.043 mg x kg(-1) x min(-1) of procedure in T_HLT patients (difference not significant). Propofol 17-25 CD59 molecule (CD59 blood group) Homo sapiens 84-90 17184435-15 2007 The mean dose of propofol required for immobility was 0.119 +/- 0.054 mg x kg(-1) x min(-1) of procedure in T_MLD patients and 0.115 +/- 0.043 mg x kg(-1) x min(-1) of procedure in T_HLT patients (difference not significant). Propofol 17-25 CD59 molecule (CD59 blood group) Homo sapiens 157-163 12960543-4 2003 Images were obtained during infusion of propofol at a rate of 50-80 microg.kg-1.min-1 and after increasing the depth of anesthesia by administering a bolus dose of propofol and increasing the infusion rate to 240 microg.kg-1.min-1. Propofol 40-48 CD59 molecule (CD59 blood group) Homo sapiens 80-85 12854478-4 2003 Propofol was also infused continuously at 4-10 mg.kg-1.min-1. Propofol 0-8 CD59 molecule (CD59 blood group) Homo sapiens 55-60 12803598-5 2003 Thirty s after the fentanyl or saline injection, a predetermined dose of 1% propofol was given at a rate of 100 mg min-1. Propofol 76-84 CD59 molecule (CD59 blood group) Homo sapiens 115-120 11359587-6 2001 Adverse respiratory events (RR < 10.min-1 or SpO2 < 90%) occurred significantly more in the propofol/remifentanil group. Propofol 98-106 CD59 molecule (CD59 blood group) Homo sapiens 39-44 11605929-7 2001 RESULTS: Plasma propofol concentrations were approximately 0.5 microg/ml for P(low) and approximately 1.3 mg/ml for P(high), Propofol reduced the central carbon dioxide sensitivity from 1.5 +/- 0.4 to 1.2 +/- 0.3 (P(low); P < 0.01 vs. control) and 0.9 +/- 0.1 l x min(-1) x mmHg(-1) (P(high); P < 0.001 vs. control). Propofol 125-133 CD59 molecule (CD59 blood group) Homo sapiens 267-273 12505938-9 2003 kg(-1) x min(-1) was increased more in the propofol group than in the control group (20 +/- 5 versus 14 +/- 4 bpm; P < 0.05). Propofol 43-51 CD59 molecule (CD59 blood group) Homo sapiens 9-15 12505938-11 2003 kg(-1) x min(-1), HR increased by more than 20 bpm in all patients in the propofol group but in only 31% of patients in the control group (P < 0.0001). Propofol 74-82 CD59 molecule (CD59 blood group) Homo sapiens 9-15 12145072-18 2002 min(-1) for propofol. Propofol 12-20 CD59 molecule (CD59 blood group) Homo sapiens 0-6 11758331-5 2001 After induction of anesthesia with propofol 50 mg, and fentanyl 100 micrograms, heart rate decreased to 36 min-1 and remained low after tracheal intubation. Propofol 35-43 CD59 molecule (CD59 blood group) Homo sapiens 107-112 10960383-5 2000 min(-1) propofol infusion in combination with 66% nitrous oxide in oxygen for maintenance of anesthesia. Propofol 8-16 CD59 molecule (CD59 blood group) Homo sapiens 0-6 10442969-2 1999 METHODS: Anesthesia was induced with 2-3 mg x kg(-1) propofol and 1 microg x kg(-1) remifentanil and maintained with 75 microg x kg(-1) x min(-1) propofol and propofol initial infusion of 0.2 microg x kg(-1) x min(-1) propofol. Propofol 146-154 CD59 molecule (CD59 blood group) Homo sapiens 138-144 10589606-5 1999 We found that patients with high trait anxiety required more propofol for both the induction (2.1+/-0.4 vs 1.8+/-0.3 mg/kg; P = 0.01) and maintenance of anesthesia (170+/-70 vs 110+/-20 microg x kg(-1) x min(-1); P = 0.02), compared with patients with low trait anxiety. Propofol 61-69 CD59 molecule (CD59 blood group) Homo sapiens 204-210 10490161-5 1999 infusion of propofol at a rate of 50 mg x min(-1) until loss of eyelash reflex and responses to verbal commands, which were judged by a blinded observer. Propofol 12-20 CD59 molecule (CD59 blood group) Homo sapiens 42-48 10442969-2 1999 METHODS: Anesthesia was induced with 2-3 mg x kg(-1) propofol and 1 microg x kg(-1) remifentanil and maintained with 75 microg x kg(-1) x min(-1) propofol and propofol initial infusion of 0.2 microg x kg(-1) x min(-1) propofol. Propofol 146-154 CD59 molecule (CD59 blood group) Homo sapiens 138-144 10442969-2 1999 METHODS: Anesthesia was induced with 2-3 mg x kg(-1) propofol and 1 microg x kg(-1) remifentanil and maintained with 75 microg x kg(-1) x min(-1) propofol and propofol initial infusion of 0.2 microg x kg(-1) x min(-1) propofol. Propofol 146-154 CD59 molecule (CD59 blood group) Homo sapiens 138-144 9640159-3 1998 Patients were anaesthetized with continuous infusion of propofol 200 micrograms kg-1 min-1. Propofol 56-64 CD59 molecule (CD59 blood group) Homo sapiens 85-90 9757923-6 1998 Systemic clearance of propofol was much higher than liver blood flow with average values on the six observation days ranging from 74.0 to 81.2 ml x min(-1) x kg(-1) and was not affected by switching from parenteral to enteral feeding. Propofol 22-30 CD59 molecule (CD59 blood group) Homo sapiens 148-154 10232720-9 1999 Anaesthesia was maintained with 120-140 microg x kg(-1) x min(-1) propofol, nitrous oxide and oxygen to maintain vital signs within 20% of baseline. Propofol 66-74 CD59 molecule (CD59 blood group) Homo sapiens 58-64 10434829-6 1999 Median blood target concentration of propofol varied from 1.0 to 1.2 micrograms ml-1 and mean propofol consumption was 50.3 (SD 17.6) micrograms kg-1 min-1. Propofol 94-102 CD59 molecule (CD59 blood group) Homo sapiens 150-155 10084096-1 1999 This double-blind, randomized trial compared the onset of sedation with two patient-controlled sedation regimens, allowing a maximum of 16 or 25 mg min-1 propofol. Propofol 154-162 CD59 molecule (CD59 blood group) Homo sapiens 148-153 10084096-5 1999 Patients receiving 16 mg min-1 propofol were not reliably sedated within 5 min and took significantly longer to develop slurred speech and amnesia (P < 0.01 for both). Propofol 31-39 CD59 molecule (CD59 blood group) Homo sapiens 25-30 9771297-1 1998 We studied effects on the EEG of propofol infused at a rate of 0.5 mg kg-1 min-1 for 10 min in 10 healthy male surgical patients under extradural analgesia. Propofol 33-41 CD59 molecule (CD59 blood group) Homo sapiens 75-80 8719187-8 1996 Throughout the rest of the surgery, more propofol was used in group 1 (77 +/- 14 micrograms/kg-1/min-1) than in group 2 (42 +/- 14 micrograms/kg-1/min-1). Propofol 41-49 CD59 molecule (CD59 blood group) Homo sapiens 97-102 9296410-7 1997 Propofol was infused at 0, 25, 50, or 75 microg x kg(-1) x min(-1) during the operation. Propofol 0-8 CD59 molecule (CD59 blood group) Homo sapiens 59-65 9296410-13 1997 Higher infusion rates of propofol (50-75 microg x kg(-1) x min(-1)) produced significant amnesia, opioid-sparing effects (alfentanil 0.3 +/- 0.2 vs 0.6 +/- 0.2 microg x kg(-1) x min(-1)), and less postoperative nausea and vomiting (P < 0.05). Propofol 25-33 CD59 molecule (CD59 blood group) Homo sapiens 59-65 9296410-13 1997 Higher infusion rates of propofol (50-75 microg x kg(-1) x min(-1)) produced significant amnesia, opioid-sparing effects (alfentanil 0.3 +/- 0.2 vs 0.6 +/- 0.2 microg x kg(-1) x min(-1)), and less postoperative nausea and vomiting (P < 0.05). Propofol 25-33 CD59 molecule (CD59 blood group) Homo sapiens 178-184 9296410-15 1997 Thus, in healthy outpatients premedicated with midazolam, 2 mg I.V., a propofol infusion of 25-50 microg x kg(-1) x min(-1) in combination with an alfentanil infusion of 0.2-0.4 microg x kg(-1) x min(-1) is recommended for sedation and analgesia during MAC in the ambulatory setting. Propofol 71-79 CD59 molecule (CD59 blood group) Homo sapiens 116-122 8908223-4 1996 METHODS: Twenty-one ASA 1 female patients scheduled for gynaecologic surgery received propofol for induction at 133 mg.min-1. Propofol 86-94 CD59 molecule (CD59 blood group) Homo sapiens 119-124 8853079-9 1996 RESULTS: Prebypass propofol at 243 +/- 57 micrograms.kg-1.min-1 decreased vascular resistance from 34 +/- 8 to 27 +/- 8 units without changing heart rate, arterial or filling pressures, cardiac index, stroke volume, or ejection fraction. Propofol 19-27 CD59 molecule (CD59 blood group) Homo sapiens 58-63 8160978-8 1994 The group of patients who received propofol alone required an average propofol dose of 221.5 +/- 71.9 micrograms.kg-1.min-1 to maintain anesthesia compared with 162.5 +/- 43.9 micrograms.kg-1.min-1 for the group receiving propofol plus nitrous oxide (P < 0.001). Propofol 70-78 CD59 molecule (CD59 blood group) Homo sapiens 118-123 7717560-10 1995 Propofol was administered (bolus 2 mg/kg + 120 micrograms.kg-1.min-1), and the electrophysiologic measurements were repeated. Propofol 0-8 CD59 molecule (CD59 blood group) Homo sapiens 63-68 8160978-8 1994 The group of patients who received propofol alone required an average propofol dose of 221.5 +/- 71.9 micrograms.kg-1.min-1 to maintain anesthesia compared with 162.5 +/- 43.9 micrograms.kg-1.min-1 for the group receiving propofol plus nitrous oxide (P < 0.001). Propofol 70-78 CD59 molecule (CD59 blood group) Homo sapiens 118-123 8457055-9 1993 Continuous infusion of 300 micrograms.kg-1.min-1 of propofol appeared to provide satisfactory anesthesia in the ewe. Propofol 52-60 CD59 molecule (CD59 blood group) Homo sapiens 43-48 8311293-5 1994 Additional data were collected during hypercarbic conditions and during a lower infusion rate of propofol (100 micrograms.kg-1 x min-1) combined with 70% nitrous oxide. Propofol 97-105 CD59 molecule (CD59 blood group) Homo sapiens 129-134 8267192-7 1993 RESULTS: The slope of the hypoxic ventilatory response curve (VE vs. SpO2) decreased from 0.88 +/- 0.15 to 0.17 +/- 0.03 l.min-1.%SpO2 -1 during propofol sedation (mean +/- SE). Propofol 145-153 CD59 molecule (CD59 blood group) Homo sapiens 123-128 8285322-7 1993 Thereafter requirements decreased: midazolam 0.065 (0.065) mg.min-1, propofol 2.1 (1.3) mg.min-1. Propofol 69-77 CD59 molecule (CD59 blood group) Homo sapiens 91-96 8130049-2 1994 Initially we studied 10 children undergoing minor procedures with spontaneous ventilation; mean duration of surgery was 38 min and mean propofol infusion rate 497 micrograms kg-1 min-1. Propofol 136-144 CD59 molecule (CD59 blood group) Homo sapiens 179-184 8130049-6 1994 Mean propofol infusion rate required to maintain anaesthesia was 474 micrograms kg-1 min-1 (range 125-737 micrograms kg-1 min-1). Propofol 5-13 CD59 molecule (CD59 blood group) Homo sapiens 85-90 8130049-6 1994 Mean propofol infusion rate required to maintain anaesthesia was 474 micrograms kg-1 min-1 (range 125-737 micrograms kg-1 min-1). Propofol 5-13 CD59 molecule (CD59 blood group) Homo sapiens 122-127 7872537-4 1994 Intubation avoiding respiratory depression: syringe pump with a fast infusion rate (50 to 100 mg.min-1), which allows induction with propofol and intubation without co-administration of muscle relaxants. Propofol 133-141 CD59 molecule (CD59 blood group) Homo sapiens 97-102 2611067-2 1989 Propofol was distributed rapidly and extensively (Vss 10.9 (1.2) litre kg-1) and cleared rapidly from the body (Cl 30.6 (2.9) ml min-1 kg-1). Propofol 0-8 CD59 molecule (CD59 blood group) Homo sapiens 129-139 1396624-2 1992 The mean doses including induction were 0.75 +/- 0.31 mg kg-1 h-1 for midazolam and 171 +/- 64 micrograms kg-1 min-1 for propofol for 46.3 +/- 17.7 min and 50.3 +/- 24.8 min respectively. Propofol 121-129 CD59 molecule (CD59 blood group) Homo sapiens 111-116 2221411-3 1990 Twenty children received 3 mg.kg-1.min-1 of propofol as a loading dose followed by a maintenance dose of 0.1 mg.kg-1.min-1 (+/- 10%). Propofol 44-52 CD59 molecule (CD59 blood group) Homo sapiens 35-40 1595920-9 1992 In four additional patients receiving smaller consecutive infusions of propofol (50 and 100 micrograms.kg-1.min-1), significant subtle increases in forearm compliance were also recorded. Propofol 71-79 CD59 molecule (CD59 blood group) Homo sapiens 108-113 1642937-3 1992 The median propofol total body clearance, derived from the apparent steady state propofol blood concentrations during infusion, was 2.11 litre min-1. Propofol 11-19 CD59 molecule (CD59 blood group) Homo sapiens 143-148 2265045-6 1990 The clearance of propofol was rapid (mean 1.6 (0.24) litre min-1). Propofol 17-25 CD59 molecule (CD59 blood group) Homo sapiens 59-64 3264120-6 1988 Rapid and slow propofol distribution half-times were observed, followed by an elimination phase with a half-time of 4-5 h. Propofol total body clearance was reduced (1.99 +/- 0.68 l.min-1) in the patients with cirrhosis but did not differ significantly from that in the control patients (2.30 +/- 0.61 l.min-1). Propofol 123-131 CD59 molecule (CD59 blood group) Homo sapiens 182-187 2803895-3 1989 Propofol 100 micrograms kg-1 min-1 and nitrous oxide in oxygen anaesthesia induced a significant decrease in amplitude of the SSEP; noxious stimulation resulted in an increase in afferent nerve transmission and a concomitant increase of amplitude of the late evoked potential. Propofol 0-8 CD59 molecule (CD59 blood group) Homo sapiens 29-34 3264120-6 1988 Rapid and slow propofol distribution half-times were observed, followed by an elimination phase with a half-time of 4-5 h. Propofol total body clearance was reduced (1.99 +/- 0.68 l.min-1) in the patients with cirrhosis but did not differ significantly from that in the control patients (2.30 +/- 0.61 l.min-1). Propofol 123-131 CD59 molecule (CD59 blood group) Homo sapiens 304-309 28181351-15 2017 The two general anesthesia groups showed lowest heart rates of 66.9 +- 15.9 min-1 for sevoflurane and 69.0 +- 11.5 min-1 for sevoflurane-propofol. Propofol 137-145 CD59 molecule (CD59 blood group) Homo sapiens 115-120 3257879-5 1988 The clearance of propofol was significantly lower in the elderly (1.44 +/- 0.10 (SE) litre min-1) than in the younger patients (1.79 +/- 0.12 litre min-1). Propofol 17-25 CD59 molecule (CD59 blood group) Homo sapiens 91-96 3257879-5 1988 The clearance of propofol was significantly lower in the elderly (1.44 +/- 0.10 (SE) litre min-1) than in the younger patients (1.79 +/- 0.12 litre min-1). Propofol 17-25 CD59 molecule (CD59 blood group) Homo sapiens 148-153 3500764-6 1987 Maintenance was extremely smooth with propofol (0.088 mg.kg-1.min-1) in 18 cases. Propofol 38-46 CD59 molecule (CD59 blood group) Homo sapiens 62-67 3122806-4 1987 We intended to start an infusion of propofol 100 micrograms kg-1 min-1; maintain it for at least 25 min; make a first set of quasi-steady-state observations; double the infusion; and repeat observations after 25 min. Propofol 36-44 CD59 molecule (CD59 blood group) Homo sapiens 65-70 3489478-2 1986 Measurements were performed with the patient awake, during steady-state maintenance anaesthesia with propofol 200 micrograms kg-1 min-1 at rest, and during sternotomy when the propofol was supplemented with fentanyl 10 micrograms kg-1. Propofol 101-109 CD59 molecule (CD59 blood group) Homo sapiens 130-135 25222854-2 2014 For most of that time, the rate of propofol was 120-160 mcg kg-1 min-1 and never exceeded 160 mcg kg-1 min-1. Propofol 35-43 CD59 molecule (CD59 blood group) Homo sapiens 65-70 28181359-7 2017 A continuous infusion of propofol was started at 150 mug kg-1 min-1 . Propofol 25-33 CD59 molecule (CD59 blood group) Homo sapiens 63-68