PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9771309-0	1998	Possible involvement of multiple human cytochrome P450 isoforms in the liver metabolism of propofol.	Propofol	91-99	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	39-54	
11298076-1	2001	AIMS: To determine the cytochrome P450 (CYP) isoforms involved in the oxidation of propofol by human liver microsomes.	Propofol	83-91	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	23-38	
11298076-1	2001	AIMS: To determine the cytochrome P450 (CYP) isoforms involved in the oxidation of propofol by human liver microsomes.	Propofol	83-91	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	40-43	
11298076-2	2001	METHODS: The rate constant calculated from the disappearance of propofol in an incubation mixture with human liver microsomes and recombinant human CYP isoforms was used as a measure of the rate of metabolism of propofol.	Propofol	212-220	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	148-151	
11298076-5	2001	The rate constants of propofol by microsomes were significantly correlated with S-mephenytoin N-demethylation, a marker of CYP2B6 (r = 0.93, P < 0.0001), but not with the metabolic activities of other CYP isoform-selective substrates.	Propofol	22-30	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	123-126	
11298076-6	2001	Of the chemical inhibitors of CYP isoforms tested, orphenadrine, a CYP2B6 inhibitor, reduced the rate constant of propofol by liver microsomes by 38% (P < 0.05), while other CYP isoform-selective inhibitors had no effects.	Propofol	114-122	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	30-33	
11298076-6	2001	Of the chemical inhibitors of CYP isoforms tested, orphenadrine, a CYP2B6 inhibitor, reduced the rate constant of propofol by liver microsomes by 38% (P < 0.05), while other CYP isoform-selective inhibitors had no effects.	Propofol	114-122	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	67-70	
11298076-7	2001	Of the recombinant CYP isoforms screened, CYP2B6 produced the highest rate constant for propofol metabolism (197 nmol min-1 nmol P450-1).	Propofol	88-96	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	19-22	
12067002-9	2002	RESULTS: Total recovery of propofol in the metabolites studied amounts to 38%, of which 62% was via the PG metabolite and 38% via cytochrome P-450.	Propofol	27-35	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	130-146	
9771309-2	1998	On the basis of potential influence of propofol on the metabolism of co-administered agents, many investigators have evaluated the effects of propofol on cytochrome P450 (CYP) activities.	Propofol	142-150	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	154-169	
9771309-2	1998	On the basis of potential influence of propofol on the metabolism of co-administered agents, many investigators have evaluated the effects of propofol on cytochrome P450 (CYP) activities.	Propofol	142-150	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	171-174	
9771309-3	1998	CYP isoforms involved in propofol metabolism are not defined.	Propofol	25-33	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3	
9771309-4	1998	In this study, our objective was to elucidate further the CYP isoforms responsible for the hydroxylation of propofol.	Propofol	108-116	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	58-61	
9771309-10	1998	This low specificity among CYP isoforms may contribute to the low interindividual variability (two-fold) and may contribute to the low level of metabolic drug interactions observed with propofol.	Propofol	186-194	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	27-30	
15769884-1	2005	The polymorphic human cytochrome P450 (P450) 2B6 is primarily responsible for the metabolism of several clinically relevant drugs including bupropion, cyclophosphamide, propofol, and efavirenz.	Propofol	169-177	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	22-48	
7695156-9	1995	These results indicate that cytochrome P-450 metabolic pathways have an important role in propofol clearance and propofol anesthetic recovery in Greyhounds.	Propofol	90-98	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	28-44	
7695156-9	1995	These results indicate that cytochrome P-450 metabolic pathways have an important role in propofol clearance and propofol anesthetic recovery in Greyhounds.	Propofol	113-121	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	28-44