PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32021281-0 2020 Propofol Inhibits the Migration and Invasion of Glioma Cells by Blocking the PI3K/AKT Pathway Through miR-206/ROCK1 Axis. Propofol 0-8 microRNA 206 Homo sapiens 102-109 28869449-0 2017 Propofol-induced neurotoxicity in hESCs involved in activation of miR-206/PUMA signal pathway. Propofol 0-8 microRNA 206 Homo sapiens 66-73 28869449-3 2017 A recent report found that propofol could significantly upregulat miR-206 expression in the human ASCs. Propofol 27-35 microRNA 206 Homo sapiens 66-73 28869449-11 2017 RESULTS: hESCs exposed to propofol showed a significant increase in TUNEL positive cells and cleaved caspase-3 expression, followed by the upregulation of miR-206 and PUMA expression. Propofol 26-34 microRNA 206 Homo sapiens 155-162 28869449-12 2017 Targeting PUMA inhibits propofol-induced cell apoptosis; miR-206 knockdown decreased propofol-induced cell apoptosis, cleaved caspase-3 and PUMA expression. Propofol 85-93 microRNA 206 Homo sapiens 57-64 28869449-13 2017 CONCLUSIONS: Propofol induce s cell death in hESC-derived neurons via activation of miR-206/PUMA signal pathway. Propofol 13-21 microRNA 206 Homo sapiens 84-91 32021281-8 2020 MiR-206 was decreased in glioma tissues and cells, while propofol exposure induced the upregulation of miR-206 in glioma cells. Propofol 57-65 microRNA 206 Homo sapiens 103-110 32021281-9 2020 Besides that, we also found overexpressed miR-206 enhanced propofol-mediated inhibition on the migration, invasion, and PI3K/AKT pathway activation of glioma cells. Propofol 59-67 microRNA 206 Homo sapiens 42-49 32021281-12 2020 The rescue assay indicated that the miR-206/ROCK1 axis was involved in propofol-induced inhibition on the migration, invasion, and PI3K/AKT pathway activation in glioma cells. Propofol 71-79 microRNA 206 Homo sapiens 36-43 32021281-13 2020 Conclusion: Propofol inhibited the migration and invasion of glioma cells by blocking the PI3K/AKT pathway through the miR-206/ROCK1 axis, suggesting an effective clinical implication for the anesthetic to prevent the metastasis of glioma. Propofol 12-20 microRNA 206 Homo sapiens 119-126