PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31556112-0 2020 PRR34-AS1 overexpression promotes protection of propofol pretreatment against ischemia/reperfusion injury in a mouse model after total knee arthroplasty via blockade of the JAK1-dependent JAK-STAT signaling pathway. Propofol 48-56 Janus kinase 1 Mus musculus 173-177 31556112-7 2020 Attenuated symptoms were observed in mice pretreated with propofol, which was evidenced by decreased positive expression rate of JAK1 protein and superoxide dismutase content along with increased malondialdehyde content and IL-10 levels. Propofol 58-66 Janus kinase 1 Mus musculus 129-133 31556112-12 2020 Upregulation of PRR34-AS1 can potentially relieve I/R injury after TKA in mice pretreated with propofol through inhibition of the JAS-STAT signaling pathway by targeting JAK1. Propofol 95-103 Janus kinase 1 Mus musculus 170-174 28542400-0 2017 Intracellular Ca2+ homeostasis and JAK1/STAT3 pathway are involved in the protective effect of propofol on BV2 microglia against hypoxia-induced inflammation and apoptosis. Propofol 95-103 Janus kinase 1 Mus musculus 35-39 28542400-10 2017 More importantly, these effects could be modulated by 25mumol/L propofol via maintaining intracellular Ca2+ homeostasis and via up-regulating the phosphorylation of JAK1 and STAT3 at Tyr705. Propofol 64-72 Janus kinase 1 Mus musculus 165-169