PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33919582-6	2021	Importantly, with an increase in solubility and permeability of piperine as a result of interaction with CD, it was proven to maintain its biological activity concerning the antioxidant potential (2,2-diphenyl-1-picryl-hydrazyl-hydrate assay), inhibition of enzymes essential for the inflammatory process and for neurodegenerative changes (hyaluronidase, acetylcholinesterase, butyrylcholinesterase).	piperine	64-72	acetylcholinesterase (Cartwright blood group)	Homo sapiens	355-375	
33544523-9	2021	The modulatory and antioxidant berberine and piperine properties on these enzymes (AChE, BChE and MAO) could be possible underlying mechanisms in employing these compounds as a complementary therapy in neurodegenerative diseases (NDDs) management.	piperine	45-53	acetylcholinesterase (Cartwright blood group)	Homo sapiens	83-87	
33178356-0	2020	Vicinal difluorination as a C=C surrogate: an analog of piperine with enhanced solubility, photostability, and acetylcholinesterase inhibitory activity.	piperine	56-64	acetylcholinesterase (Cartwright blood group)	Homo sapiens	111-131	
33178356-4	2020	We show that this fluorinated analog of piperine has superior physicochemical properties, and it also has higher potency and selectivity towards one particular drug target, acetylcholinesterase.	piperine	40-48	acetylcholinesterase (Cartwright blood group)	Homo sapiens	173-193	
31425905-7	2019	Further, to understand the nature of interactions and the conformational flexibility of piperine in the active site of recombinant human acetylcholinesterase (rhAChE), molecular docking analysis has been performed.	piperine	88-96	acetylcholinesterase (Cartwright blood group)	Homo sapiens	137-157	
31507403-7	2019	Of the four compounds screened, only curcumin (-9.6 kcal/mol) and piperine (-10.5 kcal/mol) showed favorable binding affinities and interactions towards AChE and were hence selected.	piperine	66-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	153-157	
31507403-8	2019	In vitro AChE inhibition demonstrated that combination of curcumin and piperine showed greater AChE inhibition with an IC50 of 62.81 +- 0.01 mug/ml as compared to individual compounds, i.e., IC50 of curcumin at 134.5 +- 0.06 mug/ml and IC50 of piperine at 76.6 +- 0.08 mug/ml.	piperine	71-79	acetylcholinesterase (Cartwright blood group)	Homo sapiens	9-13	
31507403-8	2019	In vitro AChE inhibition demonstrated that combination of curcumin and piperine showed greater AChE inhibition with an IC50 of 62.81 +- 0.01 mug/ml as compared to individual compounds, i.e., IC50 of curcumin at 134.5 +- 0.06 mug/ml and IC50 of piperine at 76.6 +- 0.08 mug/ml.	piperine	71-79	acetylcholinesterase (Cartwright blood group)	Homo sapiens	95-99	
33979725-3	2021	The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules.	piperine	93-101	acetylcholinesterase (Cartwright blood group)	Homo sapiens	155-159	
33979725-3	2021	The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules.	piperine	281-289	acetylcholinesterase (Cartwright blood group)	Homo sapiens	155-159	
33979725-3	2021	The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules.	piperine	281-289	acetylcholinesterase (Cartwright blood group)	Homo sapiens	340-344