PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32962126-1	2020	The bioactive piperine, a compound found in some pepper species, has been widely studied because of its therapeutic properties that include the inhibition of an important inflammation pathway triggered by interleukin-1 beta (IL-1beta).	piperine	14-22	interleukin 1 alpha	Homo sapiens	225-233	
32967203-9	2020	We found that piperine inhibited NF-kappaB by the activation of Nrf-2, blocking downstream inflammatory mediators/cytokines (TNF-alpha, IL-6, IL-1beta, Cox-2, PGE-2, iNOS, NO, MPO), triggering an antioxidant response machinery (HO-1, NQO-1, GSH, GR, GPx, CAT, SOD), scavenging ROS, and decreasing lipid peroxidation.	piperine	14-22	interleukin 1 alpha	Homo sapiens	142-150	
32962126-2	2020	However, investigation into the molecular interactions between IL-1beta and piperine is not reported in the literature.	piperine	76-84	interleukin 1 alpha	Homo sapiens	63-71	
32962126-3	2020	Here, we present for the first time the characterisation of the complex formed by IL-1beta and piperine through experimental and computational molecular biophysical analyses.	piperine	95-103	interleukin 1 alpha	Homo sapiens	82-90	
32962126-4	2020	Fluorescence spectroscopy unveiled the presence of one binding site for piperine with an affinity constant of 14.3 x 104 M-1 at 298 K. The thermodynamic analysis indicated that the interaction with IL-1beta was spontaneous ( G = -25 kJ/mol) and, when split into enthalpic and entropic contributions, the latter was more significant.	piperine	72-80	interleukin 1 alpha	Homo sapiens	198-206	
32575582-0	2020	Synthesis and Spectroscopic Analysis of Piperine- and Piperlongumine-Inspired Natural Product Scaffolds and Their Molecular Docking with IL-1beta and NF-kappaB Proteins.	piperine	40-48	interleukin 1 alpha	Homo sapiens	137-145	
32335165-11	2020	Piperine treatment significantly reduced the gene expression level of TNF-alpha, IL1-beta, NF-kappaB, and glial activation in the injured area; however, the mRNA level of IL-10, Foxp3, BDNF and MBP were significantly increased.	piperine	0-8	interleukin 1 alpha	Homo sapiens	81-89