PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23098168-0	2012	Jatrophane diterpenes from Euphorbia mellifera and their activity as P-glycoprotein modulators on multidrug-resistant mouse lymphoma and human colon adenocarcinoma cells.	jatrophane	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	69-83	
23098168-4	2012	Jatrophane diterpenes 1-3 and 5 were evaluated for their effects on the reversion of multidrug resistance (MDR) mediated by P-glycoprotein, by using the rhodamine-123 exclusion test, on human MDR1 gene-transfected mouse lymphoma cells (L5178Y MDR) and on human colon adenocarcinoma cells (COLO 320).	jatrophane	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	124-138	
23098168-4	2012	Jatrophane diterpenes 1-3 and 5 were evaluated for their effects on the reversion of multidrug resistance (MDR) mediated by P-glycoprotein, by using the rhodamine-123 exclusion test, on human MDR1 gene-transfected mouse lymphoma cells (L5178Y MDR) and on human colon adenocarcinoma cells (COLO 320).	jatrophane	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	192-196	
21192665-4	2011	The members of the ensemble of synthetic natural and non-natural jatrophanes were subsequently examined as modulators for the ABCB1, ABCG2, and ABCC1 efflux proteins, which are associated with multidrug resistance in cancer chemotherapy.	jatrophane	65-76	ATP binding cassette subfamily B member 1	Homo sapiens	126-131	
27328029-0	2016	Jatrophane Diterpenoids as Modulators of P-Glycoprotein-Dependent Multidrug Resistance (MDR): Advances of Structure-Activity Relationships and Discovery of Promising MDR Reversal Agents.	jatrophane	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	41-55	
16309213-0	2005	The effects of jatrophane derivatives on the reversion of MDR1- and MRP-mediated multidrug resistance in the MDA-MB-231 (HTB-26) cell line.	jatrophane	15-25	ATP binding cassette subfamily B member 1	Homo sapiens	58-62	
16309213-7	2005	In the present study, the MDR reversal of the same jatrophanes on MDR1- and MRP- mediated resistance of human breast cancer cells is reported.	jatrophane	51-62	ATP binding cassette subfamily B member 1	Homo sapiens	66-70	
29407947-0	2018	Jatrophane diterpenoids from Euphorbia sororia as potent modulators against P-glycoprotein-based multidrug resistance.	jatrophane	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	76-90	
29407947-3	2018	Cytotoxicity and anti-multidrug resistance effects of these jatrophane diterpenoids were evaluated in multidrug-resistant MCF-7/ADR breast cancer cells with an overexpression of P-glycoprotein (P-gp).	jatrophane	60-70	ATP binding cassette subfamily B member 1	Homo sapiens	178-192	
27387405-0	2016	Jatrophane diterpenes and cancer multidrug resistance - ABCB1 efflux modulation and selective cell death induction.	jatrophane	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	56-61	
27387405-3	2016	Herein, the isolation of another jatrophane (5) is presented, being the broader goal of this work to investigate the role of euphowelwitschines A (1) and B (2), welwitschene (3), epoxywelwitschene (4) and esulatin M (5) as ABCB1 modulators and/or collateral sensitivity agents.	jatrophane	33-43	ATP binding cassette subfamily B member 1	Homo sapiens	223-228	
32292314-3	2020	Among macrocyclic diterpenes of Euphorbia, the discovery of jatrophane and modified jatrophane diterpenes with a wide range of structurally unique polyoxygenated polycyclic derivatives and as a new class of powerful inhibitors of P-glycoprotein has opened new frontiers for research studies on this genus.	jatrophane	60-70	ATP binding cassette subfamily B member 1	Homo sapiens	230-244	
32292314-3	2020	Among macrocyclic diterpenes of Euphorbia, the discovery of jatrophane and modified jatrophane diterpenes with a wide range of structurally unique polyoxygenated polycyclic derivatives and as a new class of powerful inhibitors of P-glycoprotein has opened new frontiers for research studies on this genus.	jatrophane	84-94	ATP binding cassette subfamily B member 1	Homo sapiens	230-244	
27328029-3	2016	Thus, a jatrophane library containing two series of compounds was established to screen for P-glycoprotein (Pgp)-dependent MDR modulators.	jatrophane	8-18	ATP binding cassette subfamily B member 1	Homo sapiens	92-106	
27328029-3	2016	Thus, a jatrophane library containing two series of compounds was established to screen for P-glycoprotein (Pgp)-dependent MDR modulators.	jatrophane	8-18	ATP binding cassette subfamily B member 1	Homo sapiens	108-111