PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30728896-8 2019 Interestingly, MK591 treatment decreases protein levels and inhibits transcriptional activities of Nanog and c-Myc. MK 0591 15-20 MYC proto-oncogene, bHLH transcription factor Homo sapiens 109-114 32313135-10 2020 We found that 5-Lox regulates c-Myc signaling in enzalutamide-resistant prostate cancer cells and inhibition of 5-Lox by Quiflapon/MK591 or shRNA interrupts oncogenic c-Myc signaling and kills ERPC cells by triggering caspase-mediated apoptosis. MK 0591 121-130 MYC proto-oncogene, bHLH transcription factor Homo sapiens 167-172 32313135-10 2020 We found that 5-Lox regulates c-Myc signaling in enzalutamide-resistant prostate cancer cells and inhibition of 5-Lox by Quiflapon/MK591 or shRNA interrupts oncogenic c-Myc signaling and kills ERPC cells by triggering caspase-mediated apoptosis. MK 0591 131-136 MYC proto-oncogene, bHLH transcription factor Homo sapiens 167-172 25875826-7 2015 Interestingly, we found that treatment with MK591 dramatically down-regulates the expression of c-Myc and its targets at sub-lethal doses. MK 0591 44-49 MYC proto-oncogene, bHLH transcription factor Homo sapiens 96-101