PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19706601-0	2009	The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage.	Sterols	4-10	ring finger protein 139	Homo sapiens	63-67	
24025715-2	2013	Excess sterols cause the reductase to bind to ER membrane proteins called Insig-1 and Insig-2, which are carriers for the ubiquitin ligases gp78 and Trc8.	Sterols	7-14	ring finger protein 139	Homo sapiens	149-153	
22143767-0	2011	Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.	Sterols	0-6	ring finger protein 139	Homo sapiens	119-123	
22143767-5	2011	Knockdown of either gp78 or Trc8 in SV-589 cells through RNA interference (RNAi) inhibited sterol-induced ubiquitination of reductase and inhibited sterol-induced degradation by 50-60%.	Sterols	91-97	ring finger protein 139	Homo sapiens	28-32	
22143767-5	2011	Knockdown of either gp78 or Trc8 in SV-589 cells through RNA interference (RNAi) inhibited sterol-induced ubiquitination of reductase and inhibited sterol-induced degradation by 50-60%.	Sterols	148-154	ring finger protein 139	Homo sapiens	28-32	
22143767-9	2011	The current results suggest that sterol-induced ubiquitination and proteasomal degradation of reductase is dictated by the complex interplay of at least four proteins: Insig-1, Insig-2, gp78, and Trc8.	Sterols	33-39	ring finger protein 139	Homo sapiens	196-200	
19706601-1	2009	TRC8 (translocation in renal cancer from chromosome 8) is an intrinsic protein of the endoplasmic reticulum that contains a sterol-sensing domain and a RING finger motif encoding an E3 ubiquitin ligase.	Sterols	124-130	ring finger protein 139	Homo sapiens	0-4	
19706601-10	2009	Taken together, TRC8 is a novel sterol-sensing endoplasmic reticulum membrane protein that hinders SREBP-2 processing through interaction with SREBP-2 and SCAP, regulating its own turnover rate by means of its E3 ubiquitin ligase activity.	Sterols	32-38	ring finger protein 139	Homo sapiens	16-20	
17016439-7	2007	Expression of TRC8 represses genes involved in cholesterol and fatty acid biosynthesis that are transcriptionally regulated by the sterol response element binding proteins (SREBPs).	Sterols	52-58	ring finger protein 139	Homo sapiens	14-18	
9689122-6	1998	In the 3;8 translocation, TRC8 is fused to FHIT and is disrupted within the sterol-sensing domain.	Sterols	76-82	ring finger protein 139	Homo sapiens	26-30