PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25497967-1 2015 Plant sterols and stanols are well-known to reduce LDL-cholesterol (LDL-C) concentrations. Sterols 6-13 component of oligomeric golgi complex 2 Homo sapiens 51-66 27494447-9 2016 Compared to the first visit, non-statin and non-plant sterol treated FH children (n = 10) had significantly reduced levels of TC (p < 0.01), LDL-C (p = 0.01), high-density lipoprotein cholesterol (p = 0.02), apo B (p = 0.05) and apo A-1 (p = 0.02) levels at a later visit. Sterols 54-60 component of oligomeric golgi complex 2 Homo sapiens 144-149 25942064-5 2015 Particularly, single nucleotide polymorphisms within the genes coding for CYP7A1 and ApoE, as well as possibly other genes including ABCG5 and ABCG8, exist as predictors of whether LDL-C levels will decrease or even increase subsequent to plant sterol administration. Sterols 245-251 component of oligomeric golgi complex 2 Homo sapiens 181-186 25942754-2 2015 This supports the use of other (dietary) interventions that lower serum LDL-C concentrations via comparable mechanisms such as described for plant sterol and stanol ester enriched functional foods. Sterols 147-153 component of oligomeric golgi complex 2 Homo sapiens 72-77 25942754-5 2015 A possible advantage of plant sterol and stanol ester enriched foods over ezetimibe-a typical single-target drug-is that these dietary compounds act on multiple targets, since they not only lower serum LDL-C concentrations, but also lower serum triacylglycerol (TAG) concentrations in subjects with elevated serum TAG concentrations. Sterols 30-36 component of oligomeric golgi complex 2 Homo sapiens 202-207 25683704-1 2015 Plant sterols and stanols inhibit intestinal cholesterol absorption and consequently lower serum LDL-cholesterol (LDL-C) concentrations. Sterols 6-13 component of oligomeric golgi complex 2 Homo sapiens 97-112 25683704-1 2015 Plant sterols and stanols inhibit intestinal cholesterol absorption and consequently lower serum LDL-cholesterol (LDL-C) concentrations. Sterols 6-13 component of oligomeric golgi complex 2 Homo sapiens 114-119 25683704-3 2015 In vitro and animal studies have suggested that changes in intestinal sterol metabolism are attributed to the LDL-C-lowering effects of plant stanol esters. Sterols 70-76 component of oligomeric golgi complex 2 Homo sapiens 110-115 25497967-1 2015 Plant sterols and stanols are well-known to reduce LDL-cholesterol (LDL-C) concentrations. Sterols 6-13 component of oligomeric golgi complex 2 Homo sapiens 68-73 22018049-1 2012 Plant sterol (PS)-supplemented foods are recommended to help in lowering serum LDL-cholesterol (LDL-C). Sterols 6-12 component of oligomeric golgi complex 2 Homo sapiens 79-94 25122648-1 2014 Plant sterols (PSs) lower LDL cholesterol (LDL-C) concentrations, whereas the n-3 (omega-3) fish fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) lower triglyceride (TG) concentrations. Sterols 6-13 component of oligomeric golgi complex 2 Homo sapiens 43-48 23375753-1 2013 BACKGROUND: Consumption of plant sterols and plant stanols reduces low-density lipoprotein cholesterol (LDL-C) concentrations. Sterols 33-40 component of oligomeric golgi complex 2 Homo sapiens 104-109 23375753-8 2013 RESULTS: Compared to control, serum LDL-C concentrations were reduced after plant sterol (-8.1%; p < 0.001) and plant stanol consumption (-7.8%; p < 0.001). Sterols 82-88 component of oligomeric golgi complex 2 Homo sapiens 36-41 22087585-3 2012 Differences from control in responses (plant sterol/stanol - control) were significant (p < 0.05) for LDL-C ( - 4.9%), non-HDL-C ( - 3.6%) and TC ( - 2.8%). Sterols 45-51 component of oligomeric golgi complex 2 Homo sapiens 105-110 22018049-1 2012 Plant sterol (PS)-supplemented foods are recommended to help in lowering serum LDL-cholesterol (LDL-C). Sterols 6-12 component of oligomeric golgi complex 2 Homo sapiens 96-101 19091798-1 2009 Phytosterols (plant sterols and stanols) are well known for their LDL-cholesterol (LDL-C)-lowering effect. Sterols 5-12 component of oligomeric golgi complex 2 Homo sapiens 66-81 22397963-1 2012 Health Canada"s recent approval of plant sterols as food ingredients to decrease low-density lipoprotein cholesterol (LDL-C) is believed to be a significant step toward improving Canadians" cardiovascular health and reducing the economic burden of heart disease. Sterols 41-48 component of oligomeric golgi complex 2 Homo sapiens 81-116 22397963-1 2012 Health Canada"s recent approval of plant sterols as food ingredients to decrease low-density lipoprotein cholesterol (LDL-C) is believed to be a significant step toward improving Canadians" cardiovascular health and reducing the economic burden of heart disease. Sterols 41-48 component of oligomeric golgi complex 2 Homo sapiens 118-123 22397963-2 2012 When dyslipidemic patients consume plant sterols at a recommended daily dose of 2 g, they can reduce LDL-C by 10% to 15%, with no deleterious effects on high-density lipoprotein cholesterol. Sterols 41-48 component of oligomeric golgi complex 2 Homo sapiens 101-106 22397963-3 2012 A 10% LDL-C reduction in response to plant sterol consumption is projected to reduce heart disease risk by 25%. Sterols 43-49 component of oligomeric golgi complex 2 Homo sapiens 6-11 19091798-1 2009 Phytosterols (plant sterols and stanols) are well known for their LDL-cholesterol (LDL-C)-lowering effect. Sterols 5-12 component of oligomeric golgi complex 2 Homo sapiens 83-88 16988115-0 2006 A combination therapy including psyllium and plant sterols lowers LDL cholesterol by modifying lipoprotein metabolism in hypercholesterolemic individuals. Sterols 51-58 component of oligomeric golgi complex 2 Homo sapiens 66-81 18249205-1 2008 Plant sterols (PSs) reduce plasma total and low-density lipoprotein cholesterol (LDL-C) levels by reducing cholesterol absorption; however, it is not known whether the level of dietary cholesterol intake has an impact on the efficacy of PSs on blood lipids. Sterols 6-13 component of oligomeric golgi complex 2 Homo sapiens 81-86 21291705-1 2007 BACKGROUND: The purpose of this study was to evaluate the effects on LDL-cholesterol (LDL-C) from addition of plant sterol treatment to patients with dyslipidemia already taking a statin and colesevelam hydrochloride (HCl). Sterols 78-84 component of oligomeric golgi complex 2 Homo sapiens 86-91 21291705-2 2007 Current cholesterol treatment guidelines recommend use of plant stanols/sterols to help reach LDL-C goals in patients taking other lipid-lowering therapies. Sterols 72-79 component of oligomeric golgi complex 2 Homo sapiens 94-99 35327262-1 2022 Plant sterols/phytosterols (PSs) are molecules with a similar structure to cholesterol that have a recognized effect on elevated LDL concentrations (LDL-c). Sterols 6-13 component of oligomeric golgi complex 2 Homo sapiens 149-154 14988452-9 2004 The significant reduction in plasma LDL-C concentrations by sterol and stanol consumption in subjects was not paralleled by any beneficial changes in LDL electrophoretic characteristics. Sterols 60-66 component of oligomeric golgi complex 2 Homo sapiens 36-41 35327262-5 2022 Meta-analyses were performed to assess changes in LDL-c by treatment, food matrix, LDL-c range, sterols dosage and risk of bias (RoB). Sterols 96-103 component of oligomeric golgi complex 2 Homo sapiens 50-55 29169939-1 2018 BACKGROUND: Sitosterolemia is associated with increases in intestinal sterol absorption, low-density lipoprotein cholesterol (LDL-C), and cardiovascular disease risk. Sterols 16-22 component of oligomeric golgi complex 2 Homo sapiens 89-124 29169939-1 2018 BACKGROUND: Sitosterolemia is associated with increases in intestinal sterol absorption, low-density lipoprotein cholesterol (LDL-C), and cardiovascular disease risk. Sterols 16-22 component of oligomeric golgi complex 2 Homo sapiens 126-131 32455866-1 2020 Experimental and clinical studies have demonstrated the effect of phytosterols (PS) on reducing plasma levels of cholesterol and LDL-c, but the effects of plant sterols beyond cholesterol-lowering are still questionable. Sterols 71-78 component of oligomeric golgi complex 2 Homo sapiens 129-134 30205492-1 2018 The LDL-cholesterol (LDL-C) lowering effect of plant sterols/stanols (PSS) is summarized in several meta-analyses showing a dose-response relationship with intakes of 1.5 to 3 g/day lowering LDL-C by 7.5% to 12%. Sterols 53-60 component of oligomeric golgi complex 2 Homo sapiens 4-19 30205492-1 2018 The LDL-cholesterol (LDL-C) lowering effect of plant sterols/stanols (PSS) is summarized in several meta-analyses showing a dose-response relationship with intakes of 1.5 to 3 g/day lowering LDL-C by 7.5% to 12%. Sterols 53-60 component of oligomeric golgi complex 2 Homo sapiens 21-26 30205492-1 2018 The LDL-cholesterol (LDL-C) lowering effect of plant sterols/stanols (PSS) is summarized in several meta-analyses showing a dose-response relationship with intakes of 1.5 to 3 g/day lowering LDL-C by 7.5% to 12%. Sterols 53-60 component of oligomeric golgi complex 2 Homo sapiens 191-196 28363723-6 2017 Mechanistically, those nutraceuticals that inhibit PCSK9 through a SREBP (sterol-responsive element binding protein)-independent pathway can be more effective in lowering plasma LDL-C levels compared with those inhibiting PCSK9 through the SREBP pathway. Sterols 74-80 component of oligomeric golgi complex 2 Homo sapiens 178-183