PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16607018-3 2006 We have discovered that the ERAD proteins Ubc7 (Qri8), Cue1, and Doa10 (Ssm4) are required for growth of yeast that express high levels of the sterol biosynthetic enzyme, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR). Sterols 143-149 E2 ubiquitin-conjugating protein UBC7 Saccharomyces cerevisiae S288C 42-46 16607018-3 2006 We have discovered that the ERAD proteins Ubc7 (Qri8), Cue1, and Doa10 (Ssm4) are required for growth of yeast that express high levels of the sterol biosynthetic enzyme, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR). Sterols 143-149 E2 ubiquitin-conjugating protein UBC7 Saccharomyces cerevisiae S288C 48-52 16607018-11 2006 Cells lacking UBC7, CUE1, or DOA10 were cold sensitive, suggesting that these ERAD proteins have a role in cold adaptation, perhaps through effects on sterol biosynthesis. Sterols 151-157 E2 ubiquitin-conjugating protein UBC7 Saccharomyces cerevisiae S288C 14-18