PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16935859-0	2006	Sitosterol-containing lipoproteins trigger free sterol-induced caspase-independent death in ACAT-competent macrophages.	Sterols	4-10	carboxylesterase 1	Homo sapiens	92-96	
9500571-8	1998	The subsequent esterification of exogenous sterol was not due to CEase, but was completely dependent on ACAT activity.	Sterols	43-49	carboxylesterase 1	Homo sapiens	104-108	
9020103-9	1997	The human enzyme in yeast utilized cholesterol as the preferred sterol and was sensitive to competitive (S58035) and non-competitive (DuP 128) ACAT inhibitors.	Sterols	40-46	carboxylesterase 1	Homo sapiens	143-147	
9211065-1	1997	The conversion of cholesterol to an esterified storage form by the enzyme acyl-coenzyme A: cholesterol acyltransferase, is a critical component of sterol and membrane homeostasis and represents a significant step in atherogenesis.	Sterols	23-29	carboxylesterase 1	Homo sapiens	74-118	
8652654-1	1996	Many studies have shown that sterols can stimulate acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in cells.	Sterols	29-36	carboxylesterase 1	Homo sapiens	51-94	
8652654-1	1996	Many studies have shown that sterols can stimulate acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in cells.	Sterols	29-36	carboxylesterase 1	Homo sapiens	96-100	
8652654-2	1996	To elucidate this mechanism, effects of sterol-mediated induction on both the enzyme activity of ACAT and its mRNA levels were studied in human hepatoblastoma cell line, HepG2 cells.	Sterols	40-46	carboxylesterase 1	Homo sapiens	97-101	
8650549-2	1996	In human cells, sterol is esterified to a storage form by acyl-coenzyme A (CoA): cholesterol acyl transferase (ACAT).	Sterols	16-22	carboxylesterase 1	Homo sapiens	58-109	
8650549-2	1996	In human cells, sterol is esterified to a storage form by acyl-coenzyme A (CoA): cholesterol acyl transferase (ACAT).	Sterols	16-22	carboxylesterase 1	Homo sapiens	111-115	
7493995-8	1995	Immunoblot analysis showed that the ACAT protein contents in human fibroblast cells, HepG2 cells, or Chinese hamster ovary cells were not affected by sterol in the medium, demonstrating that the main mechanism for sterol-dependent regulation of ACAT activity in these cells is not change in ACAT protein content.	Sterols	214-220	carboxylesterase 1	Homo sapiens	36-40	
7822296-3	1995	Experiments performed in intact mammalian cells have shown that the rate of cholesteryl ester synthesis in intact cells, as well as the ACAT activity from cell extracts, are greatly activated by the addition of low density lipoprotein (LDL) or oxygenated sterols such as 25-hydroxycholesterol to the growth medium.	Sterols	255-262	carboxylesterase 1	Homo sapiens	136-140	
7822296-4	1995	However, the molecular mechanism(s) by which sterol(s) stimulate the ACAT activity remains to be elucidated.	Sterols	45-51	carboxylesterase 1	Homo sapiens	69-73	
7822296-13	1995	The combination of high level of ACAT protein expression and the low level of cellular cholesterol content in the infected cells have provided us a novel opportunity to establish a simple cell-free system, whereby stimulation of ACAT by sterols can be readily demonstrated.	Sterols	237-244	carboxylesterase 1	Homo sapiens	229-233	
6651782-1	1983	Membranes prepared from cultured fibroblasts were assayed for acyl-coenzyme A: cholesterol acyltransferase (ACAT) by a method that relied exclusively on the cholesterol already present on the membranes as the sterol substrate.	Sterols	84-90	carboxylesterase 1	Homo sapiens	108-112