PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31875875-0	2020	Mutant huntingtin interacts with the sterol regulatory element-binding proteins and impairs their nuclear import.	Sterols	37-43	huntingtin	Homo sapiens	7-17	
20378838-4	2010	Whereas mutant huntingtin fragments increased sterols in neuronal cells, SIRT2 inhibition reduced sterol levels via decreased nuclear trafficking of SREBP-2.	Sterols	46-53	huntingtin	Homo sapiens	15-25	
20378838-4	2010	Whereas mutant huntingtin fragments increased sterols in neuronal cells, SIRT2 inhibition reduced sterol levels via decreased nuclear trafficking of SREBP-2.	Sterols	46-52	huntingtin	Homo sapiens	15-25	
20378838-5	2010	Importantly, manipulation of sterol biosynthesis at the transcriptional level mimicked SIRT2 inhibition, demonstrating that the metabolic effects of SIRT2 inhibition are sufficient to diminish mutant huntingtin toxicity.	Sterols	29-35	huntingtin	Homo sapiens	200-210	
32410324-4	2020	The interaction of mutant huntingtin with sterol regulatory element-binding proteins is of particular interest given that sterol regulatory element-binding proteins play a dual role: They take part in lipid and cholesterol metabolism, but also in the inflammatory response that induces immune cell migration as well as toxic effects, particularly in astrocytes.	Sterols	42-48	huntingtin	Homo sapiens	26-36	
21894212-4	2011	Emerging evidence from human and animal studies indicates that attenuated brain sterol synthesis and accumulation of cholesterol in neuronal membranes represent two distinct mechanisms occurring in the presence of mutant huntingtin that influence neuronal survival.	Sterols	80-86	huntingtin	Homo sapiens	221-231	
20802793-5	2010	This lipid dysregulation has been linked to specific actions of the mutant huntingtin on sterol regulatory element binding proteins.	Sterols	89-95	huntingtin	Homo sapiens	75-85