PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21559365-3 2011 Here we demonstrate that cellular sterol depletion suppresses, and sterol loading induces, alternative splicing of multiple genes involved in the maintenance of cholesterol homeostasis including HMGCR and LDLR, the key regulators of cellular cholesterol biosynthesis and uptake, respectively. Sterols 34-40 low density lipoprotein receptor Homo sapiens 205-209 26153245-5 2015 This network included 11 BMI-associated genes related to sterol uptake ( LDLR, MYLIP), synthesis ( SCD, FADS1, HMGCS1, FDFT1, SQLE, CYP51A1, SC4MOL), and efflux ( ABCA1, ABCG1), producing a molecular profile expected to increase intracellular cholesterol. Sterols 57-63 low density lipoprotein receptor Homo sapiens 73-77 24899155-9 2014 Baseline synthesis precursors were associated with TG reduction in FCHL participants (P = 0.039; R(2) = 0.20), and intestinally derived sterols were inversely associated with non-HDL cholesterol changes in FH participants (P = 0.036; R(2) = 0.21). Sterols 136-143 low density lipoprotein receptor Homo sapiens 206-208 24770487-2 2014 Activated SREBP-2 translocates to the nucleus, where it binds to an LDLR promoter sterol response element (SRE), increasing LDLR gene expression and LDL-C uptake. Sterols 82-88 low density lipoprotein receptor Homo sapiens 68-72 24770487-2 2014 Activated SREBP-2 translocates to the nucleus, where it binds to an LDLR promoter sterol response element (SRE), increasing LDLR gene expression and LDL-C uptake. Sterols 82-88 low density lipoprotein receptor Homo sapiens 124-128 22153697-6 2012 However, sterols completely abolished trans-resveratrol-induced SREBP activation and LDLR gene expression. Sterols 9-16 low density lipoprotein receptor Homo sapiens 85-89 24158702-3 2014 This metabolic dependency of cancer cells on cholesterol and other lipids is tightly regulated by the cholesterol homeostasis network, including (i) sterol response element-binding proteins (SREBP), master transcriptional regulators of cholesterol and fatty acid pathway genes; (ii) nuclear sterol receptors (liver X receptors, LXR), which coordinate growth with the availability of cholesterol; and (iii) lipid particle receptors, such as low-density lipid particle (LDL) receptor, providing exogenous sterol and lipids to cancer cells. Sterols 107-113 low density lipoprotein receptor Homo sapiens 440-481 22936343-3 2012 In response to rising cellular sterol levels, activated LXR induces IDOL production, thereby limiting further uptake of exogenous cholesterol through the LDLR pathway. Sterols 31-37 low density lipoprotein receptor Homo sapiens 154-158 22936343-4 2012 The LXR-IDOL-LDLR mechanism for feedback inhibition of cholesterol uptake is independent of and complementary to the sterol regulatory element-binding protein pathway. Sterols 60-66 low density lipoprotein receptor Homo sapiens 13-17 21559365-3 2011 Here we demonstrate that cellular sterol depletion suppresses, and sterol loading induces, alternative splicing of multiple genes involved in the maintenance of cholesterol homeostasis including HMGCR and LDLR, the key regulators of cellular cholesterol biosynthesis and uptake, respectively. Sterols 67-73 low density lipoprotein receptor Homo sapiens 205-209 21294679-8 2011 The unique sterol-independent LDLR repression by organelle stress via ATF3 demonstrated here could be involved in obesity-related hypercholesterolemia, which can lead to insulin resistance and type 2 diabetes. Sterols 11-17 low density lipoprotein receptor Homo sapiens 30-34 20863500-4 2010 RESULTS: These experiments showed that SREBP-1a couples the stimulatory effect of GH on cholesterol regulated genes, e.g. LDL receptor gene, via sterol sensitive binding cis-element (sre-1). Sterols 93-99 low density lipoprotein receptor Homo sapiens 122-134 16787396-4 2006 Thus, expression levels of three major sterol-sensitive genes, that is sterol-regulatory element binding protein 2 (SREBP-2), hydroxymethylglutaryl-coenzyme A (HMGCoA) reductase and low-density lipoprotein (LDL) receptor, were monitored to study the cell response to the addition of LDL-derived cholesterol. Sterols 39-45 low density lipoprotein receptor Homo sapiens 182-220 19322023-7 2009 PGC-1alpha might be a novel modulator of LDLR gene expression in a sterol-independent manner, and implicated in atherogenesis. Sterols 67-73 low density lipoprotein receptor Homo sapiens 41-45 23105564-6 2006 This comparative study makes it consistent that cell saturation with sterol (beta-estradiol) is the prime regulator of LDL-receptor expression between the two hormones, insulin and estrogen. Sterols 69-75 low density lipoprotein receptor Homo sapiens 119-131 16415294-7 2006 We further found that in human embryonic kidney HEK 293 cells, the 15-ketosterol suppressed sterol-responsive element binding protein processing activity and thus inhibited mRNA expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, LDL receptor, and PCSK9. Sterols 74-80 low density lipoprotein receptor Homo sapiens 241-253 16054075-2 2005 While the mRNA expression of the LDLR and the newly studied proprotein convertase PCSK9 are coordinately upregulated in absence of sterols, the latter proteinase apparently enhances the degradation of the LDLR protein. Sterols 131-138 low density lipoprotein receptor Homo sapiens 33-37 16292665-3 2006 The expression of the LDL receptor gene is under an intriguing regulation by sterol and nonsterol mediators either at the transcriptional level or at the posttranscriptional level, both of which are linked to cell signaling pathways. Sterols 77-83 low density lipoprotein receptor Homo sapiens 22-34 11792717-3 2002 This region binds Sp1 and collaborates with repeat 2 in the regulation of LDLR gene by sterols. Sterols 87-94 low density lipoprotein receptor Homo sapiens 74-78 15514256-8 2004 When HepG2 cells were transiently transfected with HMG CoA synthase and LDL receptor reporter plasmids there was an increase in expression in response to soy extract or isoflavone treatment from both of these promoters, but this induction was blunted in the presence of sterols (P < 0.05). Sterols 270-277 low density lipoprotein receptor Homo sapiens 72-84 12110376-7 2002 The LDL receptor expression in vincristine resistant Pgp positive K562 cells was less sensitive to downregulation by sterols than in parental cells. Sterols 117-124 low density lipoprotein receptor Homo sapiens 4-16 11997513-7 2002 Antisense treatment decreased endogenous PKC epsilon protein levels and completely blocked induction of LDL receptor transcription following sterol depletion. Sterols 141-147 low density lipoprotein receptor Homo sapiens 104-116 11997513-11 2002 Altogether, these results define a novel signaling pathway leading to induction of LDL receptor transcription following sterol depletion, and a model is proposed to account for a new function for PKC epsilon as part of a sterol-sensitive signal transduction pathway in hepatic cells. Sterols 120-126 low density lipoprotein receptor Homo sapiens 83-95 12718903-8 2003 Finally, we show that the infectious LDLR locus retains classical expression regulation by sterol levels in human cells. Sterols 91-97 low density lipoprotein receptor Homo sapiens 37-41 12235180-1 2002 Previously, we identified the low density lipoprotein receptor (LDLR) promoter region -17 to -1 as a novel sterol-independent regulatory element (SIRE) that mediates the stimulating effect of oncostatin M (OM). Sterols 107-113 low density lipoprotein receptor Homo sapiens 30-62 12235180-1 2002 Previously, we identified the low density lipoprotein receptor (LDLR) promoter region -17 to -1 as a novel sterol-independent regulatory element (SIRE) that mediates the stimulating effect of oncostatin M (OM). Sterols 107-113 low density lipoprotein receptor Homo sapiens 64-68 11795856-3 2001 The recent finding that elevated LDL receptor activity in acute myelogenous leukemia cells was characterized by a decreased sensitivity to downregulation by sterols raises the possibility that the mechanism behind this is related to the cellular growth rate. Sterols 157-164 low density lipoprotein receptor Homo sapiens 33-45 11726974-5 2001 Using human hepatoma cells, we show that these compounds act through the sterol-responsive element of the LDLr promoter and activate the SCAP/SREBP pathway, leading to increased LDLr expression and activity, even in presence of excess of sterols. Sterols 73-79 low density lipoprotein receptor Homo sapiens 178-182 11726974-5 2001 Using human hepatoma cells, we show that these compounds act through the sterol-responsive element of the LDLr promoter and activate the SCAP/SREBP pathway, leading to increased LDLr expression and activity, even in presence of excess of sterols. Sterols 238-245 low density lipoprotein receptor Homo sapiens 106-110 11726974-5 2001 Using human hepatoma cells, we show that these compounds act through the sterol-responsive element of the LDLr promoter and activate the SCAP/SREBP pathway, leading to increased LDLr expression and activity, even in presence of excess of sterols. Sterols 238-245 low density lipoprotein receptor Homo sapiens 178-182 11795856-2 2001 Studies on cultured cells have shown that growing cells have a higher LDL uptake than quiescent cells and that incubation of cells with growth factors or mitogenic compounds leads to sterol-resistant upregulation of LDL receptor gene expression. Sterols 183-189 low density lipoprotein receptor Homo sapiens 216-228 11726974-5 2001 Using human hepatoma cells, we show that these compounds act through the sterol-responsive element of the LDLr promoter and activate the SCAP/SREBP pathway, leading to increased LDLr expression and activity, even in presence of excess of sterols. Sterols 73-79 low density lipoprotein receptor Homo sapiens 106-110 11250935-5 2001 We also show that mutation at the sterol-responsive element-1 site diminishes the activity of ERalpha on LDLR transcription, thereby suggesting that the sterol-responsive element-1-binding protein may interact with the Sp1-ERalpha complex to trans-activate LDLR gene transcription. Sterols 34-40 low density lipoprotein receptor Homo sapiens 105-109 11545736-1 2001 A synthetic drug, T113242, activates low-density lipoprotein receptor (LDLR) transcription in the presence of sterols. Sterols 110-117 low density lipoprotein receptor Homo sapiens 37-69 11545736-1 2001 A synthetic drug, T113242, activates low-density lipoprotein receptor (LDLR) transcription in the presence of sterols. Sterols 110-117 low density lipoprotein receptor Homo sapiens 71-75 11416012-9 2001 As LDL receptor gene expression in other tissues is negatively regulated by the abundance of intracellular free cholesterol, we assessed the impact of concomitant pretreatment of granulosa-luteal cells with an exogenous soluble sterol (25-hydroxycholesterol, 1 and 10 microM). Sterols 117-123 low density lipoprotein receptor Homo sapiens 3-15 11416012-10 2001 Excess sterol markedly (50-70%) attenuated bihormonally and, in lesser measure, LH-stimulated and basal LDL receptor promoter expression, thus affirming a feedback-sensitive sterol-repressive region in this gene. Sterols 7-13 low density lipoprotein receptor Homo sapiens 104-116 11416012-10 2001 Excess sterol markedly (50-70%) attenuated bihormonally and, in lesser measure, LH-stimulated and basal LDL receptor promoter expression, thus affirming a feedback-sensitive sterol-repressive region in this gene. Sterols 174-180 low density lipoprotein receptor Homo sapiens 104-116 11483628-2 2001 CTalpha mRNA levels, like farnesyl diphosphate synthase and the LDL receptor, are repressed when human or rodent cells are incubated with exogenous sterols and induced when cells are incubated in lipid-depleted medium. Sterols 148-155 low density lipoprotein receptor Homo sapiens 64-76 11250935-5 2001 We also show that mutation at the sterol-responsive element-1 site diminishes the activity of ERalpha on LDLR transcription, thereby suggesting that the sterol-responsive element-1-binding protein may interact with the Sp1-ERalpha complex to trans-activate LDLR gene transcription. Sterols 34-40 low density lipoprotein receptor Homo sapiens 257-261 11250935-5 2001 We also show that mutation at the sterol-responsive element-1 site diminishes the activity of ERalpha on LDLR transcription, thereby suggesting that the sterol-responsive element-1-binding protein may interact with the Sp1-ERalpha complex to trans-activate LDLR gene transcription. Sterols 153-159 low density lipoprotein receptor Homo sapiens 105-109 11250935-5 2001 We also show that mutation at the sterol-responsive element-1 site diminishes the activity of ERalpha on LDLR transcription, thereby suggesting that the sterol-responsive element-1-binding protein may interact with the Sp1-ERalpha complex to trans-activate LDLR gene transcription. Sterols 153-159 low density lipoprotein receptor Homo sapiens 257-261 10391894-2 1999 In this paper, we report that SB202190 alone, a specific inhibitor of p38(MAPK), induces low density lipoprotein (LDL) receptor expression (6-8-fold) in a sterol-sensitive manner in HepG2 cells. Sterols 155-161 low density lipoprotein receptor Homo sapiens 93-127 10894816-0 2000 Interleukin-6 stimulates LDL receptor gene expression via activation of sterol-responsive and Sp1 binding elements. Sterols 72-78 low density lipoprotein receptor Homo sapiens 25-37 10894816-11 2000 This effect is sterol independent and involves, on the molecular level, activation of nuclear factors binding to SRE-1 and the Sp1 binding site in repeat 2 and repeat 3 of the LDL-R promoter, respectively. Sterols 15-21 low density lipoprotein receptor Homo sapiens 176-181 10671569-6 2000 This study identifies, for the first time, a cis-acting regulatory element in the LDLR promoter that is responsible for sterol-independent regulation of LDLR transcription. Sterols 120-126 low density lipoprotein receptor Homo sapiens 82-86 10671569-6 2000 This study identifies, for the first time, a cis-acting regulatory element in the LDLR promoter that is responsible for sterol-independent regulation of LDLR transcription. Sterols 120-126 low density lipoprotein receptor Homo sapiens 153-157 10841543-2 2000 We show that activation of SREBPs by sterol depletion results in the increased binding of Sp1 to a site adjacent to SREBP in the promoter for the low density lipoprotein (LDL) receptor gene in vivo. Sterols 37-43 low density lipoprotein receptor Homo sapiens 146-184 9717725-2 1998 PMA and ionomycin likewise increased LDL receptor mRNA levels when cells were cultured in the presence of suppressive concentrations of sterols, when neither SREBP-1 nor SREBP-2 was detectable in the nucleus. Sterols 136-143 low density lipoprotein receptor Homo sapiens 37-49 9989262-3 1999 Sterols regulate the expression of the LDL receptor, HMG-CoA reductase, squalene synthase and fatty acid synthase in 23-11 cells as they also do in the parental cell line HeLa S3. Sterols 0-7 low density lipoprotein receptor Homo sapiens 39-51 9717725-0 1998 Sterol-independent, sterol response element-dependent, regulation of low density lipoprotein receptor gene expression. Sterols 0-6 low density lipoprotein receptor Homo sapiens 69-101 9717725-0 1998 Sterol-independent, sterol response element-dependent, regulation of low density lipoprotein receptor gene expression. Sterols 20-26 low density lipoprotein receptor Homo sapiens 69-101 9651391-8 1998 We conclude that when cells are incubated in the absence of sterols, the transcriptional activation of the HMG-CoA synthase, HMG-CoA reductase, FPP synthase, and low density lipoprotein receptor genes is dependent on a specific interaction between SREBP, which is bound to the promoter DNA, and the amino-terminal domain (amino acids 1-451) of CBP. Sterols 60-67 low density lipoprotein receptor Homo sapiens 162-194 10037774-2 1999 Our previous studies showed that mutations within the repeat 3 sequence of the LDLR promoter significantly decreased OM activity on LDLR promoter luciferase reporter constructs that contain the sterol responsive element-1 (repeat 2) and Sp1 binding sites (repeats 1 and 3). Sterols 194-200 low density lipoprotein receptor Homo sapiens 79-83 10037774-2 1999 Our previous studies showed that mutations within the repeat 3 sequence of the LDLR promoter significantly decreased OM activity on LDLR promoter luciferase reporter constructs that contain the sterol responsive element-1 (repeat 2) and Sp1 binding sites (repeats 1 and 3). Sterols 194-200 low density lipoprotein receptor Homo sapiens 132-136 9624172-10 1998 These results show that IL-1beta- or TNF-induced LDL receptor expression requires ERK-1/2 activation, that the p38(MAPK) pathway negatively regulates LDL receptor expression, and that sterols inhibit induction at a point downstream of ERK-1/2 in HepG2 cells. Sterols 184-191 low density lipoprotein receptor Homo sapiens 49-61 9624172-10 1998 These results show that IL-1beta- or TNF-induced LDL receptor expression requires ERK-1/2 activation, that the p38(MAPK) pathway negatively regulates LDL receptor expression, and that sterols inhibit induction at a point downstream of ERK-1/2 in HepG2 cells. Sterols 184-191 low density lipoprotein receptor Homo sapiens 150-162 9641167-8 1998 CONCLUSION: TNF alpha, TGF beta, PDGF and IL-1beta increased LDLr gene expression by increasing sterol-independent and mitogenesis-independent gene transcription. Sterols 96-102 low density lipoprotein receptor Homo sapiens 61-65 9275065-4 1997 LDLR activation by estrogen in HepG2 cells is dependent on the presence of exogenous estrogen receptor, and the estrogen-responsive region of the LDLR promoter colocalizes with the sterol response element previously identified. Sterols 181-187 low density lipoprotein receptor Homo sapiens 0-4 9458267-0 1997 Decreased feedback regulation of low density lipoprotein receptor activity by sterols in leukemic cells from patients with acute myelogenous leukemia. Sterols 78-85 low density lipoprotein receptor Homo sapiens 33-65 9458267-6 1997 At the highest sterol concentration (0.400 microg/mL 25-hydroxycholesterol + 8 microg/mL cholesterol), the LDL-receptor activity was abolished in cells from all healthy individuals while the induction of LDL-receptor activity in cells from three AML patients was unaffected. Sterols 15-21 low density lipoprotein receptor Homo sapiens 107-119 9458267-6 1997 At the highest sterol concentration (0.400 microg/mL 25-hydroxycholesterol + 8 microg/mL cholesterol), the LDL-receptor activity was abolished in cells from all healthy individuals while the induction of LDL-receptor activity in cells from three AML patients was unaffected. Sterols 15-21 low density lipoprotein receptor Homo sapiens 204-216 9321669-1 1997 Low density lipoprotein (LDL) receptor gene is regulated at the transcriptional level by the intracellular level of sterols in animal cells. Sterols 116-123 low density lipoprotein receptor Homo sapiens 0-38 9478045-6 1998 As the amount of dietary cholesterol entering the body is increased, there is expansion of the sterol pool in the liver cell and down regulation of LDL receptors (LDLR) that are primarily responsible for clearing LDL-C from the blood stream. Sterols 30-36 low density lipoprotein receptor Homo sapiens 148-161 9478045-6 1998 As the amount of dietary cholesterol entering the body is increased, there is expansion of the sterol pool in the liver cell and down regulation of LDL receptors (LDLR) that are primarily responsible for clearing LDL-C from the blood stream. Sterols 30-36 low density lipoprotein receptor Homo sapiens 163-167 9409246-11 1997 The expression of LDL receptor regulated by the sterol regulatory element was increased by pravastatin, but not by gemfibrozil. Sterols 48-54 low density lipoprotein receptor Homo sapiens 18-30 9275065-4 1997 LDLR activation by estrogen in HepG2 cells is dependent on the presence of exogenous estrogen receptor, and the estrogen-responsive region of the LDLR promoter colocalizes with the sterol response element previously identified. Sterols 181-187 low density lipoprotein receptor Homo sapiens 146-150 9164239-8 1997 In mammals, a sterol-derived metabolic signal regulates the expression of genes required for lipoprotein synthesis and for the LDL receptor. Sterols 14-20 low density lipoprotein receptor Homo sapiens 127-139 8969230-9 1996 We conclude that transcriptional induction of the LDL receptor gene in response to sterol depletion is mediated, in part, by an highly conserved novel cis-acting element through the binding of specific nuclear protein(s). Sterols 83-89 low density lipoprotein receptor Homo sapiens 50-62 7592765-4 1995 Hypermethylation within the SRE of the low density lipoprotein receptor promoter was observed when cells were treated with cholesterol synthesis inhibitors, insulin, or phorbol 12-myristate 13-acetate, suggesting that the SRE regulates this promoter through sterol-independent as well as sterol-dependent mechanisms. Sterols 128-134 low density lipoprotein receptor Homo sapiens 39-71 8947512-5 1996 Further, an inverse relationship was also observed between sterol modulated LDL-receptor gene transcription and the binding affinity of this 47 kDa factor to the SRE sequence. Sterols 59-65 low density lipoprotein receptor Homo sapiens 76-88 8636148-4 1996 Successive 5" deletions of the LDL receptor promoter fragment from -537 to +88 revealed the sterol regulatory element 1 (SRE-1) between -65 and -56 as an insulin- and estradiol-sensitive cis-element. Sterols 92-98 low density lipoprotein receptor Homo sapiens 31-43 8932516-1 1996 Serum factors stimulate low density lipoprotein receptor (LDLR) gene expression in HepG2 cells through sterol-independent pathways. Sterols 103-109 low density lipoprotein receptor Homo sapiens 24-56 8932516-1 1996 Serum factors stimulate low density lipoprotein receptor (LDLR) gene expression in HepG2 cells through sterol-independent pathways. Sterols 103-109 low density lipoprotein receptor Homo sapiens 58-62 9116058-2 1996 This period of increasing LDL receptor activity coincided with a high resistance to cholesterol down-regulation which suggested a sterol-independent pathway of stimulation. Sterols 89-95 low density lipoprotein receptor Homo sapiens 26-38 8820113-1 1996 The hypothesis that mitochondrial sterol 27-hydroxylase plays a role in the sterol-mediated down-regulation of LDL receptor activity was evaluated in HepG2 cells. Sterols 34-40 low density lipoprotein receptor Homo sapiens 111-123 7592765-4 1995 Hypermethylation within the SRE of the low density lipoprotein receptor promoter was observed when cells were treated with cholesterol synthesis inhibitors, insulin, or phorbol 12-myristate 13-acetate, suggesting that the SRE regulates this promoter through sterol-independent as well as sterol-dependent mechanisms. Sterols 258-264 low density lipoprotein receptor Homo sapiens 39-71 8305487-1 1994 Sterol-dependent regulation of low-density lipoprotein (LDL) receptor gene expression was studied in the human hepatoma HepG2 cell line. Sterols 0-6 low density lipoprotein receptor Homo sapiens 31-69 7597088-1 1995 Feedback regulation of transcription from the low density lipoprotein (LDL) receptor gene is fundamentally important in the maintenance of intracellular sterol balance. Sterols 153-159 low density lipoprotein receptor Homo sapiens 46-84 7627719-2 1995 This portion of the LDL receptor gene encompasses a previously characterized sterol response element and an adjacent Sp1 binding site. Sterols 77-83 low density lipoprotein receptor Homo sapiens 20-32 7751827-1 1995 Protein-DNA interactions within a region of the LDL receptor promoter involved in sterol-mediated feedback repression of transcription were examined using in vivo genomic footprinting with dimethylsulfate (DMS). Sterols 82-88 low density lipoprotein receptor Homo sapiens 48-60 8387332-11 1993 The results suggest that LDL receptor expression in CaCo-2 cells is regulated by luminal sterol flux and that this regulation occurs at the level of transcription. Sterols 89-95 low density lipoprotein receptor Homo sapiens 25-37 8314806-10 1993 The current data are consistent with the concept that SREBP acts in concert with Sp1 to achieve high level, sterol-suppressible transcription of the gene for the LDL receptor. Sterols 108-114 low density lipoprotein receptor Homo sapiens 162-174 8402897-1 1993 Sterol regulatory element 1 (SRE-1), a decamer (5"-ATC-ACCCCAC-3") flanking the low density lipoprotein (LDL) receptor gene, activates transcription in sterol-depleted cells and is silenced by sterols. Sterols 152-158 low density lipoprotein receptor Homo sapiens 80-118 2086705-10 1990 By contrast, the oxygenated sterol, 25-hydroxycholesterol, and mevalonate, the precursor of endogenously synthesized sterols, down-regulated LDL receptor mRNA levels comparably in mitogen-stimulated and control PBMC. Sterols 28-34 low density lipoprotein receptor Homo sapiens 141-153 1313231-11 1992 We propose that our results are evidence for a cyclic AMP-stimulated, sterol-independent, control of LDL-receptor synthesis which is of widespread occurrence in human cells. Sterols 70-76 low density lipoprotein receptor Homo sapiens 101-113 1816322-8 1991 Both cholestyramine and low dietary sterols stimulated low density lipoprotein receptor function. Sterols 36-43 low density lipoprotein receptor Homo sapiens 55-87 1930137-0 1991 Evidence for sterol-independent regulation of low-density lipoprotein receptor activity in Hep-G2 cells. Sterols 13-19 low density lipoprotein receptor Homo sapiens 46-78 1709932-6 1991 Administration of sterols repressed Xenopus LDL receptor mRNA in cultured A6 kidney cells and in the liver of intact frogs. Sterols 18-25 low density lipoprotein receptor Homo sapiens 44-56 1709932-10 1991 We conclude that the structural gene for the LDL receptor has been under sterol-mediated regulation at least since the time of amphibian development more than 350 million years ago. Sterols 73-79 low density lipoprotein receptor Homo sapiens 45-57 2066678-6 1991 These data support the concept that the apoE gene be considered among the family of genes sensitively regulated by cellular sterol balance but suggest that the molecular mechanism accounting for the modulation of the LDL receptor and apoE genes are distinct, with the relationship between cell sterol balance and apoE gene regulation being more complex. Sterols 124-130 low density lipoprotein receptor Homo sapiens 217-229 2086705-10 1990 By contrast, the oxygenated sterol, 25-hydroxycholesterol, and mevalonate, the precursor of endogenously synthesized sterols, down-regulated LDL receptor mRNA levels comparably in mitogen-stimulated and control PBMC. Sterols 117-124 low density lipoprotein receptor Homo sapiens 141-153 1970801-1 1990 Cellular cholesterol metabolism is regulated primarily through sterol-mediated feedback suppression of the activity of the low-density lipoprotein receptor and several enzymes of the cholesterol biosynthetic pathway. Sterols 14-20 low density lipoprotein receptor Homo sapiens 123-155 2688859-5 1989 We suggest that the LDL receptor gene in human steroidogenic cells is under negative control by a sterol effector, but that a cyclic AMP triggered process overcomes, to some extent, the sterol-mediated suppression. Sterols 98-104 low density lipoprotein receptor Homo sapiens 20-32 2562787-1 1989 Cholesterol balance in mammalian cells is maintained in part by sterol-mediated repression of gene transcription for the low density lipoprotein receptor and enzymes in the cholesterol biosynthetic pathway. Sterols 5-11 low density lipoprotein receptor Homo sapiens 121-153 2180958-1 1990 The relationship between growth- and sterol-related regulation of low density lipoprotein (LDL) receptor gene expression was examined in human skin fibroblasts. Sterols 37-43 low density lipoprotein receptor Homo sapiens 66-104 2180958-5 1990 Acute transfection experiments using sterol-responsive elements of the LDL receptor gene indicated that these elements are also responsive to growth activation with PDGF. Sterols 37-43 low density lipoprotein receptor Homo sapiens 71-83 2180958-6 1990 These data indicate that alteration of cellular sterol balance or metabolism leading to release of end product repression contributes to growth-related stimulation of LDL receptor gene expression. Sterols 48-54 low density lipoprotein receptor Homo sapiens 167-179 34742012-15 2022 Furthermore, expression level was decreased for the key genes LDLR, FASN and HMGCR, those required for sterol biosynthesis. Sterols 103-109 low density lipoprotein receptor Homo sapiens 62-66 2688859-5 1989 We suggest that the LDL receptor gene in human steroidogenic cells is under negative control by a sterol effector, but that a cyclic AMP triggered process overcomes, to some extent, the sterol-mediated suppression. Sterols 186-192 low density lipoprotein receptor Homo sapiens 20-32 2688859-6 1989 The detailed mechanisms by which sterol and cyclic AMP modulate LDL receptor gene expression remain to be elucidated. Sterols 33-39 low density lipoprotein receptor Homo sapiens 64-76 2638531-6 1989 Mitogenic stimulation thus provides a signal that increases LDL receptor gene expression over and above that predicted from the concentration of exogenous sterols. Sterols 155-162 low density lipoprotein receptor Homo sapiens 60-72 2471639-7 1989 These findings suggest that one action of insulin in these cells may be to promote transcription of the LDL-receptor gene by a mechanism that can override the sterol regulatory pathway. Sterols 159-165 low density lipoprotein receptor Homo sapiens 104-116 2912432-2 1989 Lymphocytes from patients homozygous for familial hypercholesterolemia (FH) lack low density lipoprotein (LDL) receptors, and, therefore, these patients cannot use LDL cholesterol to support proliferation when endogenous sterol synthesis is blocked. Sterols 60-66 low density lipoprotein receptor Homo sapiens 72-74 3794551-0 1986 Expression of low density lipoprotein receptor in cultured human granulosa cells: regulation by human chorionic gonadotropin, cyclic AMP, and sterol. Sterols 142-148 low density lipoprotein receptor Homo sapiens 14-46 3401291-12 1988 The ineffective downregulation of sterol synthesis is most probably due to both the cholesterol content of the LDLs and their reduced binding to the LDL receptor. Sterols 34-40 low density lipoprotein receptor Homo sapiens 149-161 3390448-6 1988 These findings reveal differential regulation of HMG-CoA reductase and LDL receptor mRNAs in the presence of sterol negative feedback. Sterols 109-115 low density lipoprotein receptor Homo sapiens 71-83 3357417-7 1988 The decreased uptake and degradation of LDLs relative to LDLn by normal cells suggest that abnormal plant sterols in LDLs may reduce its affinity for the native LDL receptor. Sterols 106-113 low density lipoprotein receptor Homo sapiens 161-173 3357417-8 1988 Increased receptor-mediated uptake and degradation of LDLs by sitosterolemic cells in the presence of high cellular sterol content may result from failure of the sitosterolemic cells to down-regulate LDL receptor synthesis. Sterols 66-72 low density lipoprotein receptor Homo sapiens 200-212 3269672-4 1988 When exogenous sterol was provided as a plasma lipoprotein, LDL receptor-mediated interaction with apolipoprotein-B or -E was essential for the provision of cholesterol to normal human lymphocytes. Sterols 15-21 low density lipoprotein receptor Homo sapiens 60-72 7234377-0 1980 LDL receptor studies in term and pre-term infants: Measurement of sterol synthesis in cord blood lymphocytes. Sterols 66-72 low density lipoprotein receptor Homo sapiens 0-12 6313765-9 1983 Exposure of cells to lipoprotein cholesterol in the form of LDL also enhanced HDL binding by a process related to delivery of sterol into cells via the LDL receptor pathway. Sterols 38-44 low density lipoprotein receptor Homo sapiens 152-164 4055779-7 1985 This would suggest some regulation of LDL receptor synthesis by negative feedback of sterol. Sterols 85-91 low density lipoprotein receptor Homo sapiens 38-50 4031008-1 1985 In nonsteroidogenic cells, cellular cholesterol requirements and sterol availability determine low density lipoprotein (LDL) receptor expression and LDL metabolism. Sterols 41-47 low density lipoprotein receptor Homo sapiens 99-133 32065674-5 2020 Our results suggest that incubation of HepG2 cells with a ratio of sterols that mimic the plasma concentration seen in phytosterolemia patients reduces cholesterol esterification, total cholesterol synthesis, and inhibits LDLR mRNA abundance. Sterols 67-74 low density lipoprotein receptor Homo sapiens 222-226 7446092-0 1980 LDL receptor studies in children with heterozygous familial hypercholesterolemia (FH): measurement of sterol synthesis in blood lymphocytes. Sterols 70-76 low density lipoprotein receptor Homo sapiens 0-12 7446092-0 1980 LDL receptor studies in children with heterozygous familial hypercholesterolemia (FH): measurement of sterol synthesis in blood lymphocytes. Sterols 70-76 low density lipoprotein receptor Homo sapiens 82-84 7446092-1 1980 Sterol synthesis was measured in lymphocytes from 48 members of 10 families with familial hypercholesterolemia (FH) under three sets of conditions. Sterols 0-6 low density lipoprotein receptor Homo sapiens 81-110 7446092-1 1980 Sterol synthesis was measured in lymphocytes from 48 members of 10 families with familial hypercholesterolemia (FH) under three sets of conditions. Sterols 0-6 low density lipoprotein receptor Homo sapiens 112-114 7446092-4 1980 In five of the ten families LDL suppression of sterol synthesis in FH heterozygotes was only about half of the LDL suppression in normals. Sterols 47-53 low density lipoprotein receptor Homo sapiens 67-69 32727844-2 2020 The sterol-responsive E3 ubiquitin ligase inducible degrader of the LDLR (IDOL) specifically promotes ubiquitination and subsequent lysosomal degradation of the LDLR and thus controls cellular LDL uptake. Sterols 4-10 low density lipoprotein receptor Homo sapiens 68-72 32727844-2 2020 The sterol-responsive E3 ubiquitin ligase inducible degrader of the LDLR (IDOL) specifically promotes ubiquitination and subsequent lysosomal degradation of the LDLR and thus controls cellular LDL uptake. Sterols 4-10 low density lipoprotein receptor Homo sapiens 161-165 32065674-0 2020 A Phytosterolemic Mixture of Sterols Inhibits Cholesterol Synthesis, Esterification, and Low-Density Lipoprotein Receptor mRNA Abundance in HepG2 Cells. Sterols 29-36 low density lipoprotein receptor Homo sapiens 89-121 31795497-2 2019 At present, it is known that the pathogenesis of this disease involves not only a pathological variant of low-density lipoprotein receptor and its ligands (apolipoprotein B, proprotein convertase subtilisin/kexin type 9 or low-density lipoprotein receptor adaptor protein 1), but also lipids, including sphingolipids, fatty acids, and sterols. Sterols 335-342 low density lipoprotein receptor Homo sapiens 106-138