PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19074854-1 2008 Cdc25C is a dual-specificity phosphatase that is involved in induction of mitosis by removal of the inhibitory phosphates from cyclin-dependent kinase 1/cyclin B. Phosphates 111-121 cyclin dependent kinase 1 Homo sapiens 127-152 23525902-3 2013 The complexity of Cdk1 regulation has made it difficult to determine whether these different roles require different thresholds of kinase activity and whether the surge of activity as inhibitory phosphates are removed at mitotic onset is essential for cell proliferation. Phosphates 195-205 cyclin dependent kinase 1 Homo sapiens 18-22 22982242-6 2012 We also found that inactive Cdk1 is caused by the sustained inactivation of CDC25B, which removes the inhibitory phosphate from Cdk1. Phosphates 113-122 cyclin dependent kinase 1 Homo sapiens 28-32 22982242-6 2012 We also found that inactive Cdk1 is caused by the sustained inactivation of CDC25B, which removes the inhibitory phosphate from Cdk1. Phosphates 113-122 cyclin dependent kinase 1 Homo sapiens 128-132 19223768-4 2009 Cdc25 phosphatases can activate Cdks by removing inhibitory phosphates from Cdks. Phosphates 60-70 cyclin dependent kinase 1 Homo sapiens 32-36 19223768-4 2009 Cdc25 phosphatases can activate Cdks by removing inhibitory phosphates from Cdks. Phosphates 60-70 cyclin dependent kinase 1 Homo sapiens 76-80 25483135-7 2014 These unexpected complexities in Cdk1 inhibitory phosphorylation demonstrate that the checkpoint mechanism is not a simple binary "off/on" switch, but has at least three distinct states: "Ready", to prevent chromosome damage and apoptosis, "Set", for developmentally regulated G2 phase arrest, and "Go", when Cdc25 phosphatases remove inhibitory phosphates to trigger Cdk1 activation at the G2/M transition. Phosphates 346-356 cyclin dependent kinase 1 Homo sapiens 33-37 21569376-4 2011 We found that the characteristic dephosphorylation of an inhibitory phosphate on Cdk1 did not occur in infected cells expressing Vif. Phosphates 68-77 cyclin dependent kinase 1 Homo sapiens 81-85 20368335-1 2010 Cdc25A is a dual specificity protein phosphatase that activates cyclin/cyclin-dependent protein kinase (Cdk) complexes by removing inhibitory phosphates from conserved threonine and tyrosine in Cdks. Phosphates 142-152 cyclin dependent kinase 1 Homo sapiens 104-107 20368335-1 2010 Cdc25A is a dual specificity protein phosphatase that activates cyclin/cyclin-dependent protein kinase (Cdk) complexes by removing inhibitory phosphates from conserved threonine and tyrosine in Cdks. Phosphates 142-152 cyclin dependent kinase 1 Homo sapiens 194-198 17912454-1 2007 Human CDC25 phosphatases play an important role in cell cycle regulation by removing inhibitory phosphate groups on cyclin-CDKs. Phosphates 96-105 cyclin dependent kinase 1 Homo sapiens 123-127 18272572-5 2008 In uninfected cells, the cdc25C phosphatase activates cdc2 by removing two inhibitory phosphates. Phosphates 86-96 cyclin dependent kinase 1 Homo sapiens 25-29 18234856-2 2008 Cdk1 was engineered to accept an ATP analog that allows it to uniquely label its substrates with a bio-orthogonal phosphate analog tag. Phosphates 114-123 cyclin dependent kinase 1 Homo sapiens 0-4 15107615-2 2004 The Cdc25 protein phosphatase family activates Cdk1-cyclin B at the G2/M transition by removing inhibitory phosphate groups. Phosphates 107-116 cyclin dependent kinase 1 Homo sapiens 47-51 17172867-5 2006 Specifically, the Cdk1/Cyclin-B1-dependent phosphate groups on Ser115 and Ser320 of Cdc25A were found to be removed by Cdc14A. Phosphates 43-52 cyclin dependent kinase 1 Homo sapiens 18-22 11896603-1 2002 Cdc25 activates maturation promoting factor (MPF) and promotes mitosis by removing the inhibitory phosphate from the Tyr-15 of Cdc2 in human cells. Phosphates 98-107 cyclin dependent kinase 1 Homo sapiens 0-4 14645578-10 2003 At late times, we observed accumulation of the Cdc25 phosphatases that remove the inhibitory phosphates from Cdk1. Phosphates 93-103 cyclin dependent kinase 1 Homo sapiens 109-113 11719058-3 2001 A switch-like mechanism integrates signals of cellular status and commits the cell to mitosis by abruptly removing inhibitory phosphate from preformed cyclin:Cdk1 complexes. Phosphates 126-135 cyclin dependent kinase 1 Homo sapiens 158-162 11278490-2 2001 In mammalian cells, the G(2) checkpoint prevents the Cdc25C phosphatase from removing inhibitory phosphate groups from the mitosis-promoting kinase Cdc2. Phosphates 97-106 cyclin dependent kinase 1 Homo sapiens 53-57 7528141-3 1994 Comparison of the phosphorylation kinetics with those found for the tyrosine residues on a peptide comprising the regulatory tyrosine phosphorylation site of cdc2 points to the role of the primary sequence context of the phosphate acceptor. Phosphates 221-230 cyclin dependent kinase 1 Homo sapiens 158-162 11027648-7 2000 Chk1 phosphorylates cdc25C on serine 216 and inactivates it whereas cdc25C dephosphorylates tyrosine 15 phosphate of cdc2 and activates the cdc2-cyclin B complex. Phosphates 104-113 cyclin dependent kinase 1 Homo sapiens 68-72 10681541-3 2000 In most species, the G(2) checkpoint prevents the Cdc25 phosphatase from removing inhibitory phosphate groups from the mitosis-promoting kinase Cdc2. Phosphates 93-102 cyclin dependent kinase 1 Homo sapiens 50-54 9492343-5 1998 Activation of cyclin B/Cdk1 at the onset of mitosis is accomplished by a phosphatase, Cdc25C, that interacts with cyclin B/Cdk1 in an autocatalytic feedback loop to remove the inhibitory phosphate at Tyr15 and activate kinase activity. Phosphates 187-196 cyclin dependent kinase 1 Homo sapiens 23-27 9492343-5 1998 Activation of cyclin B/Cdk1 at the onset of mitosis is accomplished by a phosphatase, Cdc25C, that interacts with cyclin B/Cdk1 in an autocatalytic feedback loop to remove the inhibitory phosphate at Tyr15 and activate kinase activity. Phosphates 187-196 cyclin dependent kinase 1 Homo sapiens 123-127 9376363-4 1997 Using cdc2 kinase, 7-10 mol of phosphoryl groups was incorporated per mole of MAP2, and more than 60% of the phosphates was distributed to the microtubule-binding region. Phosphates 109-119 cyclin dependent kinase 1 Homo sapiens 6-10 7864866-7 1995 On the other hand cdc2-cyclin B introduced up to 0.8 mol/mol phosphate into isolated I2 and four phosphopeptides were obtained. Phosphates 61-70 cyclin dependent kinase 1 Homo sapiens 18-22 8048926-1 1994 A 100kD microtubule-bundling protein dynamin was phosphorylated in vitro by cdc2 kinase to approximately 1 mol of phosphate/mol of dynamin at a serine residue. Phosphates 114-123 cyclin dependent kinase 1 Homo sapiens 76-80 8276402-1 1993 The human CDC25 tyrosine phosphatases trigger activation of CDC2 by removing inhibitory phosphates; thus the genes encoding these phosphatases may be suspected as potential oncogenes due to their role in promoting cell division. Phosphates 88-98 cyclin dependent kinase 1 Homo sapiens 10-14 2016282-2 1991 In this study we have demonstrated that smooth muscle caldesmon is phosphorylated in vitro by cdc2 kinase from mitotic phase HeLa cells to 1.2 mol of phosphate/mol of caldesmon. Phosphates 150-159 cyclin dependent kinase 1 Homo sapiens 94-98 8250970-4 1993 L86-8275 inhibited [32P]orthophosphate labeling of p34cdc2 threonine and tyrosine residues and decreased the phosphotyrosine content of p34cdc2. Phosphates 24-38 cyclin dependent kinase 1 Homo sapiens 51-58 8397207-3 1993 Activation of cdk2-catalyzed H1 kinase activity by cyclin A required a 10-min preincubation of the two components, whereas cdc2 kinase supported phosphate incorporation without a detectable time lag upon the addition of cyclin B1, suggesting a slower association rate of cdk2 with cyclin A compared with cdc2 and cyclin B1. Phosphates 145-154 cyclin dependent kinase 1 Homo sapiens 123-127 1587853-5 1992 The molar ratio of incorporated phosphate/rap1GAP was approximately 3 by cAMP-dependent kinase and 2 by p34cdc2. Phosphates 32-41 cyclin dependent kinase 1 Homo sapiens 104-111 35412245-7 2022 We employed an "analog-sensitive" Cdk1 to bio-orthogonally and uniquely label its substrates in the NE with a phosphate analog tag. Phosphates 110-119 cyclin dependent kinase 1 Homo sapiens 34-38