PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31140554-9 2020 Inhibition of AMD1 by an inhibitor SAM486A in human gastric cancer cells arrested cell cycle progression during G1-to-S transition. 4-amidinoindan-1-one 2'-amidinohydrazone 35-42 adenosylmethionine decarboxylase 1 Homo sapiens 14-18 15965903-9 2006 Pre-treatment with CGP 48664, an S-adenosylmethionine decarboxylase (SAMDC) inhibitor markedly reduced spermidine and spermine levels, and provoked effects similar to those caused by DFMO. 4-amidinoindan-1-one 2'-amidinohydrazone 19-28 adenosylmethionine decarboxylase 1 Homo sapiens 33-67 19584241-0 2009 Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma. 4-amidinoindan-1-one 2'-amidinohydrazone 62-69 adenosylmethionine decarboxylase 1 Homo sapiens 14-48 19584241-2 2009 The second-generation inhibitor SAM486A inhibits AdoMetDC enzyme activity and has been evaluated in phase II clinical cancer trials. 4-amidinoindan-1-one 2'-amidinohydrazone 32-39 adenosylmethionine decarboxylase 1 Homo sapiens 49-57 15965903-9 2006 Pre-treatment with CGP 48664, an S-adenosylmethionine decarboxylase (SAMDC) inhibitor markedly reduced spermidine and spermine levels, and provoked effects similar to those caused by DFMO. 4-amidinoindan-1-one 2'-amidinohydrazone 19-28 adenosylmethionine decarboxylase 1 Homo sapiens 69-74 15704548-2 2004 DFMO and SAM486A are specific inhibitors of ODC and AdoMetDC, respectively, and are the only two PA inhibitors, which have been clinically evaluated in Phase II and III cancer trials. 4-amidinoindan-1-one 2'-amidinohydrazone 9-16 adenosylmethionine decarboxylase 1 Homo sapiens 52-60 16007177-3 2005 Treatment with DFMO in combination with SAM486A, an S-adenosylmethionine decarboxylase (AdoMetDC) inhibitor, has been shown to enhance polyamine pool depletion. 4-amidinoindan-1-one 2'-amidinohydrazone 40-47 adenosylmethionine decarboxylase 1 Homo sapiens 52-86 16007177-3 2005 Treatment with DFMO in combination with SAM486A, an S-adenosylmethionine decarboxylase (AdoMetDC) inhibitor, has been shown to enhance polyamine pool depletion. 4-amidinoindan-1-one 2'-amidinohydrazone 40-47 adenosylmethionine decarboxylase 1 Homo sapiens 88-96 16170669-6 2005 Treatment of cells with a second inhibitor of polyamine biosynthesis, the S-adenosylmethionine decarboxylase (SAMDC) inhibitor SAM486A, also resulted in a dosage dependent decrease in meprin alpha and MMP-7 mRNA. 4-amidinoindan-1-one 2'-amidinohydrazone 127-134 adenosylmethionine decarboxylase 1 Homo sapiens 74-108 16170669-6 2005 Treatment of cells with a second inhibitor of polyamine biosynthesis, the S-adenosylmethionine decarboxylase (SAMDC) inhibitor SAM486A, also resulted in a dosage dependent decrease in meprin alpha and MMP-7 mRNA. 4-amidinoindan-1-one 2'-amidinohydrazone 127-134 adenosylmethionine decarboxylase 1 Homo sapiens 110-115 15547724-0 2004 Biological activity of the S-adenosylmethionine decarboxylase inhibitor SAM486A in human breast cancer cells in vitro and in vivo. 4-amidinoindan-1-one 2'-amidinohydrazone 72-79 adenosylmethionine decarboxylase 1 Homo sapiens 27-61 15547724-1 2004 The antitumor activity of the S-adenosylmethionine decarboxylase (SAMDC) inhibitor SAM486A in human breast cancer cells was investigated. 4-amidinoindan-1-one 2'-amidinohydrazone 83-90 adenosylmethionine decarboxylase 1 Homo sapiens 30-64 15547724-1 2004 The antitumor activity of the S-adenosylmethionine decarboxylase (SAMDC) inhibitor SAM486A in human breast cancer cells was investigated. 4-amidinoindan-1-one 2'-amidinohydrazone 83-90 adenosylmethionine decarboxylase 1 Homo sapiens 66-71 12114416-1 2002 PURPOSE: SAM486A is a novel inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC). 4-amidinoindan-1-one 2'-amidinohydrazone 9-16 adenosylmethionine decarboxylase 1 Homo sapiens 75-109 12114416-1 2002 PURPOSE: SAM486A is a novel inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC). 4-amidinoindan-1-one 2'-amidinohydrazone 9-16 adenosylmethionine decarboxylase 1 Homo sapiens 111-116 12114416-11 2002 Analysis of paired tumor biopsy specimens taken before and after SAM486A treatment in 1 patient with metastatic melanoma revealed decreased SAMDC activity, increased ornithine decarboxylase activity, increased levels of putrescine, and depleted levels of decarboxylated S-adenosylmethionine and spermine, all of which are consistent with the proposed mode of action of SAM486A. 4-amidinoindan-1-one 2'-amidinohydrazone 65-72 adenosylmethionine decarboxylase 1 Homo sapiens 140-145 10944598-2 2000 SAM486A (CGP 48664) is a new inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC), more potent and specific than the first-generation SAMDC inhibitor methylglyoxal (bis) guanylhydrazone (MGBG). 4-amidinoindan-1-one 2'-amidinohydrazone 0-7 adenosylmethionine decarboxylase 1 Homo sapiens 76-110 10944598-2 2000 SAM486A (CGP 48664) is a new inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC), more potent and specific than the first-generation SAMDC inhibitor methylglyoxal (bis) guanylhydrazone (MGBG). 4-amidinoindan-1-one 2'-amidinohydrazone 0-7 adenosylmethionine decarboxylase 1 Homo sapiens 112-117 10944598-2 2000 SAM486A (CGP 48664) is a new inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC), more potent and specific than the first-generation SAMDC inhibitor methylglyoxal (bis) guanylhydrazone (MGBG). 4-amidinoindan-1-one 2'-amidinohydrazone 0-7 adenosylmethionine decarboxylase 1 Homo sapiens 171-176 10944598-2 2000 SAM486A (CGP 48664) is a new inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC), more potent and specific than the first-generation SAMDC inhibitor methylglyoxal (bis) guanylhydrazone (MGBG). 4-amidinoindan-1-one 2'-amidinohydrazone 9-18 adenosylmethionine decarboxylase 1 Homo sapiens 76-110 10944598-2 2000 SAM486A (CGP 48664) is a new inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC), more potent and specific than the first-generation SAMDC inhibitor methylglyoxal (bis) guanylhydrazone (MGBG). 4-amidinoindan-1-one 2'-amidinohydrazone 9-18 adenosylmethionine decarboxylase 1 Homo sapiens 112-117 10944598-2 2000 SAM486A (CGP 48664) is a new inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC), more potent and specific than the first-generation SAMDC inhibitor methylglyoxal (bis) guanylhydrazone (MGBG). 4-amidinoindan-1-one 2'-amidinohydrazone 9-18 adenosylmethionine decarboxylase 1 Homo sapiens 171-176 7640515-1 1995 CGP 48664A (4-amidinoindan-1-one2"-amidinohydrazone) is a novel inhibitor of S-adenosyl-methionine decarboxylase (SAMDC), a key enzyme in the biosynthesis of polyamines, which are themselves essential for proliferation of mammalian cells. 4-amidinoindan-1-one 2'-amidinohydrazone 12-51 adenosylmethionine decarboxylase 1 Homo sapiens 77-112 7640515-1 1995 CGP 48664A (4-amidinoindan-1-one2"-amidinohydrazone) is a novel inhibitor of S-adenosyl-methionine decarboxylase (SAMDC), a key enzyme in the biosynthesis of polyamines, which are themselves essential for proliferation of mammalian cells. 4-amidinoindan-1-one 2'-amidinohydrazone 12-51 adenosylmethionine decarboxylase 1 Homo sapiens 114-119 14535654-15 2003 Disregarding DFMO, the AdoMetDC inhibitor SAM486A is the only compound for which clinical trials were published. 4-amidinoindan-1-one 2'-amidinohydrazone 42-49 adenosylmethionine decarboxylase 1 Homo sapiens 23-31 11698350-3 2001 In order to further explore this possibility, we used SAM-486A and alpha-difluoromethylornithine (DFMO), which are inhibitors of S-adenosylmethionine decarboxylase (SAMDC), and ornithine decarboxylase (ODC), respectively, either alone or in combination to reduce the intracellular polyamine levels. 4-amidinoindan-1-one 2'-amidinohydrazone 54-62 adenosylmethionine decarboxylase 1 Homo sapiens 129-163 11698350-3 2001 In order to further explore this possibility, we used SAM-486A and alpha-difluoromethylornithine (DFMO), which are inhibitors of S-adenosylmethionine decarboxylase (SAMDC), and ornithine decarboxylase (ODC), respectively, either alone or in combination to reduce the intracellular polyamine levels. 4-amidinoindan-1-one 2'-amidinohydrazone 54-62 adenosylmethionine decarboxylase 1 Homo sapiens 165-170 8877009-7 1996 The ability of CGP48664 to inhibit MCF-7 cell proliferation was related to its ability to inhibit SAMDC and to consequently deplete spermidine and spermine levels in the cell. 4-amidinoindan-1-one 2'-amidinohydrazone 15-23 adenosylmethionine decarboxylase 1 Homo sapiens 98-103 7635576-1 1995 CGP 48664 [4-aminoindanon-1-(2"-amidino)hydrazone dihydrochloride monohydrate] is a newly introduced inhibitor of S-adenosylmethionine decarboxylase (SAMDC) with increased selectivity of action and reduced toxicity. 4-amidinoindan-1-one 2'-amidinohydrazone 0-9 adenosylmethionine decarboxylase 1 Homo sapiens 114-148 7635576-1 1995 CGP 48664 [4-aminoindanon-1-(2"-amidino)hydrazone dihydrochloride monohydrate] is a newly introduced inhibitor of S-adenosylmethionine decarboxylase (SAMDC) with increased selectivity of action and reduced toxicity. 4-amidinoindan-1-one 2'-amidinohydrazone 0-9 adenosylmethionine decarboxylase 1 Homo sapiens 150-155