PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1630156-8	1992	Similar to earlier studies examining erythromycin N-demethylation in younger subjects, CYP3A activity was found to vary with gender in the geriatric cohort.	erythromycin n	37-51	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	87-92	
23327575-6	2013	CYP3A4 erythromycin N-demethylation activity was 40% lower in CYP3A4*22 carriers compared with CYP3A4*1/*1 patients (p = 0.032).	erythromycin n	7-21	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6	
23327575-6	2013	CYP3A4 erythromycin N-demethylation activity was 40% lower in CYP3A4*22 carriers compared with CYP3A4*1/*1 patients (p = 0.032).	erythromycin n	7-21	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	62-68	
23327575-6	2013	CYP3A4 erythromycin N-demethylation activity was 40% lower in CYP3A4*22 carriers compared with CYP3A4*1/*1 patients (p = 0.032).	erythromycin n	7-21	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	62-68	
15770073-2	2005	An extract of Evodia fruit in the presence of NADPH was shown to inhibit human liver microsomal erythromycin N-demethylation activity, mediated by cytochrome P450 3A4 (CYP3A4), in a preincubation-time dependent manner.	erythromycin n	96-110	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	147-166	
15770073-2	2005	An extract of Evodia fruit in the presence of NADPH was shown to inhibit human liver microsomal erythromycin N-demethylation activity, mediated by cytochrome P450 3A4 (CYP3A4), in a preincubation-time dependent manner.	erythromycin n	96-110	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	168-174	
10511057-11	1999	CONCLUSION: Although both erythromycin N-demethylation and the metabolism of midazolam by hydroxylation are mediated by CYP3A, the phenotypic trait measures associated with these two in vivo probe drugs do not provide the same information about the catalytic activity of the enzyme.	erythromycin n	26-40	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	120-125	
17988092-2	2007	The methanolic extract of fennel showed a characteristic of mechanism-based inactivation on erythromycin N-demethylation mediated by human liver microsomal cytochrome P450 3A4 (CYP3A4).	erythromycin n	92-106	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	156-175	
17988092-2	2007	The methanolic extract of fennel showed a characteristic of mechanism-based inactivation on erythromycin N-demethylation mediated by human liver microsomal cytochrome P450 3A4 (CYP3A4).	erythromycin n	92-106	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	177-183	
9566442-3	1997	The kinetics of erythromycin N-demethylation were best described by a one-site Michaelis-Menten model with autoinhibition and the apparent kinetic parameters for pooled human liver microsomes (HLM; Km=88 microM, Vmax=345 pmol/min/mg) and expressed CYP3A4 (Km=33 microM, Vmax=130 pmol/min/ mg) were in good agreement.	erythromycin n	16-30	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	248-254	
1732074-4	1992	New noninvasive tests of CYP3A strongly suggest cortisol 6 beta-hydroxylation and erythromycin N-demethylation are performed by distinct CYP3A isoforms.	erythromycin n	82-96	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	25-30	
1732074-4	1992	New noninvasive tests of CYP3A strongly suggest cortisol 6 beta-hydroxylation and erythromycin N-demethylation are performed by distinct CYP3A isoforms.	erythromycin n	82-96	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	137-142