PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30391799-8 2019 The altered molecular signaling pathways demonstrated the great potential of DFMT to overcome rituximab resistance resulting from either down-regulation of CD20 or endocytosis and trogocytosis of rituximab/CD20 complexes. dfmt 77-81 keratin 20 Homo sapiens 156-160 34361811-4 2021 Here, we intend to demonstrate that DFMT is a platform that will be effective on other receptors than previously validated CD20. dfmt 36-40 keratin 20 Homo sapiens 123-127 30639670-6 2019 Pretreatment of cells with gemcitabine (GEM) or polymer-gemcitabine conjugate (2P-GEM) enhanced CD20 expression levels thus increasing apoptosis induced by DFMT. dfmt 156-160 keratin 20 Homo sapiens 96-100 30391799-8 2019 The altered molecular signaling pathways demonstrated the great potential of DFMT to overcome rituximab resistance resulting from either down-regulation of CD20 or endocytosis and trogocytosis of rituximab/CD20 complexes. dfmt 77-81 keratin 20 Homo sapiens 206-210 30259654-1 2018 A therapeutic platform-drug-free macromolecular therapeutics (DFMT)-that induces apoptosis in B cells by cross-linking of CD20 receptors, without the need for low molecular weight cytotoxic drug, is developed. dfmt 62-66 keratin 20 Homo sapiens 122-126 30198798-3 2019 Without the need of low molecular weight drug, the hybridisation of morpholino oligonucleotide containing DFMT at NHL cell surface triggers CD20 crosslinking and subsequent apoptosis. dfmt 106-110 keratin 20 Homo sapiens 140-144 30198798-6 2019 Compared with other cell cycle states, cells arrested at G2/M phase exhibit enhanced CD20 expression, and have more sustainable CD20 binding by DFMT, resulting in a higher degree of DFMT-mediated CD20 crosslinking. dfmt 144-148 keratin 20 Homo sapiens 128-132 30198798-6 2019 Compared with other cell cycle states, cells arrested at G2/M phase exhibit enhanced CD20 expression, and have more sustainable CD20 binding by DFMT, resulting in a higher degree of DFMT-mediated CD20 crosslinking. dfmt 144-148 keratin 20 Homo sapiens 128-132 30198798-6 2019 Compared with other cell cycle states, cells arrested at G2/M phase exhibit enhanced CD20 expression, and have more sustainable CD20 binding by DFMT, resulting in a higher degree of DFMT-mediated CD20 crosslinking. dfmt 182-186 keratin 20 Homo sapiens 128-132 30198798-6 2019 Compared with other cell cycle states, cells arrested at G2/M phase exhibit enhanced CD20 expression, and have more sustainable CD20 binding by DFMT, resulting in a higher degree of DFMT-mediated CD20 crosslinking. dfmt 182-186 keratin 20 Homo sapiens 128-132 30259654-7 2018 Selective surface binding of DFMT to CD20+ cells is validated in experiments on a coculture of CD20+ (Raji) and CD20-(DG-75) cells. dfmt 29-33 keratin 20 Homo sapiens 37-41 30259654-7 2018 Selective surface binding of DFMT to CD20+ cells is validated in experiments on a coculture of CD20+ (Raji) and CD20-(DG-75) cells. dfmt 29-33 keratin 20 Homo sapiens 95-99 30259654-7 2018 Selective surface binding of DFMT to CD20+ cells is validated in experiments on a coculture of CD20+ (Raji) and CD20-(DG-75) cells. dfmt 29-33 keratin 20 Homo sapiens 95-99 29595951-2 2018 Here, we apply drug-free macromolecular therapeutics (DFMT) that amplifies CD20 cross-linking to enhance apoptosis in RTX-resistant cells. dfmt 54-58 keratin 20 Homo sapiens 75-79 29595951-5 2018 Moreover, the restoration of CD20 expression by the pretreatment of cells with a polymer-gemcitabine conjugate, a CD20 expression enhancer, unleashes the full potential of DFMT in the CD20-deficient resistant cells. dfmt 172-176 keratin 20 Homo sapiens 114-118 29595951-5 2018 Moreover, the restoration of CD20 expression by the pretreatment of cells with a polymer-gemcitabine conjugate, a CD20 expression enhancer, unleashes the full potential of DFMT in the CD20-deficient resistant cells. dfmt 172-176 keratin 20 Homo sapiens 114-118 29595951-5 2018 Moreover, the restoration of CD20 expression by the pretreatment of cells with a polymer-gemcitabine conjugate, a CD20 expression enhancer, unleashes the full potential of DFMT in the CD20-deficient resistant cells. dfmt 172-176 keratin 20 Homo sapiens 29-33